product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human Perforin
catalog :
308111
quantity :
25 tests
price :
149 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
dG9
reactivity :
human
application :
immunocytochemistry
more info or order :
citations: 14
Reference
Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, et al. Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Front Immunol. 2022;13:1063313 pubmed publisher
Jung I, Narayan V, McDonald S, Rech A, Bartoszek R, Hong G, et al. BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion. Sci Transl Med. 2022;14:eabn7336 pubmed publisher
Hirschberger S, Gellert L, Effinger D, Muenchhoff M, Herrmann M, Briegel J, et al. Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection. Front Med (Lausanne). 2022;9:923502 pubmed publisher
Myers J, Schirm D, Bendzick L, Hopps R, Selleck C, Hinderlie P, et al. Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion. JCI Insight. 2022;7: pubmed publisher
Shen C, Zhang Z, Tian Y, Li F, Zhou L, Jiang W, et al. Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway. BMC Med. 2021;19:283 pubmed publisher
Carri xf3 n B, Liu Y, Hadi M, Lundstrom J, Christensen J, Ammitzb xf8 ll C, et al. Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
Loo Yau H, Bell E, Ettayebi I, de Almeida F, Boukhaled G, Shen S, et al. DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells. Mol Cell. 2021;81:1469-1483.e8 pubmed publisher
Chen R, Xiao Z, Yan X, Han P, Liang F, Wang J, et al. Tumor Cell-Secreted ISG15 Promotes Tumor Cell Migration and Immune Suppression by Inducing the Macrophage M2-Like Phenotype. Front Immunol. 2020;11:594775 pubmed publisher
Alhaj Hussen K, Michonneau D, Biajoux V, Keita S, Dubouchet L, Nelson E, et al. CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease. Front Immunol. 2020;11:579776 pubmed publisher
Wang F, Li B, Wei Y, Zhao Y, Wang L, Zhang P, et al. Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression. Oncogenesis. 2018;7:41 pubmed publisher
Alhaj Hussen K, Vu Manh T, Guimiot F, Nelson E, Chabaane E, Delord M, et al. Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis. Immunity. 2017;47:680-696.e8 pubmed publisher
Jie H, Srivastava R, Argiris A, Bauman J, Kane L, Ferris R. Increased PD-1+ and TIM-3+ TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients. Cancer Immunol Res. 2017;5:408-416 pubmed publisher
Jilek S, Schluep M, Harari A, Canales M, Lysandropoulos A, Zekeridou A, et al. HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis. J Immunol. 2012;188:4671-80 pubmed publisher
Grogan B, Tabellini L, Storer B, Bumgarner T, Astigarraga C, Flowers M, et al. Activation and expansion of CD8(+) T effector cells in patients with chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2011;17:1121-32 pubmed publisher
product information
Antigen :
Perforin
Apps. Abbrev. :
ICFC
Cat # :
308111
Clone :
dG9
Item :
APC anti-human Perforin
Isotype :
Mouse IgG2b, κ
Other Names :
PRF1, P1, PFP, HPLH2
Size :
25 tests
Price (USD) :
149 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
Purified granules from the human lymphoma cell line
Application Notes :
Clone dG9 primarily recognizes perforin associated with cytotoxic granules^9. Additional reported applications (for the relevant formats) include: immunoprecipitation, intracellular flow cytometric analysis and immunofluorescence microscopy^5,7, and immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections^1,4.;Does not cross-react with mouse^1.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA