product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human Perforin
catalog :
308106
quantity :
100 tests
price :
304 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
dG9
reactivity :
human
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 15
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2a
Ingegnere T, Mariotti F, Pelosi A, Quintarelli C, De Angelis B, Tumino N, et al. Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing. Front Immunol. 2019;10:957 pubmed publisher
Georg P, Astaburuaga García R, Bonaguro L, Brumhard S, Michalick L, Lippert L, et al. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell. 2022;185:493-512.e25 pubmed publisher
Hejazi M, Zhang C, Bennstein S, Balz V, Reusing S, Quadflieg M, et al. CD33 Delineates Two Functionally Distinct NK Cell Populations Divergent in Cytokine Production and Antibody-Mediated Cellular Cytotoxicity. Front Immunol. 2021;12:798087 pubmed publisher
Van der Meer J, de Jonge P, van der Waart A, Geerlings A, Moonen J, Brummelman J, et al. CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice. Oncoimmunology. 2021;10:1981049 pubmed publisher
Woan K, Kim H, Bjordahl R, Davis Z, Gaidarova S, Goulding J, et al. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell. 2021;28:2062-2075.e5 pubmed publisher
Hegewisch Solloa E, Seo S, Mundy Bosse B, Mishra A, Waldman E, Maurrasse S, et al. Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage. J Immunol. 2021;207:950-965 pubmed publisher
Seo I, Lee S, Noh T, Kim J, Joo H, Shin E, et al. Increase of Vδ2+ T Cells That Robustly Produce IL-17A in Advanced Abdominal Aortic Aneurysm Tissues. Immune Netw. 2021;21:e17 pubmed publisher
Van der Meer J, Maas R, Guldevall K, Klarenaar K, de Jonge P, Evert J, et al. IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells. Cancer Immunol Immunother. 2021;70:1305-1321 pubmed publisher
Hu X, Liu Y, Zhang X, Kong D, Kong J, Zhao D, et al. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer. Neoplasia. 2020;22:539-553 pubmed publisher
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, et al. Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages. Cell. 2018;175:442-457.e23 pubmed publisher
Tang Huau T, Guéguen P, Goudot C, Durand M, Bohec M, Baulande S, et al. Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway. Nat Commun. 2018;9:2570 pubmed publisher
Lettau M, Armbrust F, Dohmen K, Drews L, Poch T, Dietz M, et al. Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol. 2018;30:215-228 pubmed publisher
Liu C, Min X, Wang N, Wang J, Ma N, Dong X, et al. Complement Receptor 3 Has Negative Impact on Tumor Surveillance through Suppression of Natural Killer Cell Function. Front Immunol. 2017;8:1602 pubmed publisher
Bertino P, Urschitz J, Hoffmann F, You B, Rose A, Park W, et al. Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses. Vaccine. 2014;32:1670-7 pubmed publisher
Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee H, Steinle A. NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009;113:358-69 pubmed publisher
product information
Antigen :
Perforin
Apps. Abbrev. :
ICFC
Cat # :
308106
Clone :
dG9
Item :
PE anti-human Perforin
Isotype :
Mouse IgG2b, κ
Other Names :
PRF1, P1, PFP, HPLH2
Size :
100 tests
Price (USD) :
304 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Immunogen :
Purified granules from the human lymphoma cell line
Application Notes :
Clone dG9 primarily recognizes perforin associated with cytotoxic granules^9. Additional reported applications (for the relevant formats) include: immunoprecipitation, intracellular flow cytometric analysis and immunofluorescence microscopy^5,7, and immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections^1,4.;Does not cross-react with mouse^1.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA