PE/Dazzle™ 594 anti-human HLA-DR | BioLegend 307653 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Dazzle™ 594 anti-human HLA-DR

catalog :

307653

quantity :

25 tests

price :

141 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

L243

reactivity :

human, rhesus macaque

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
	Okoye A, Fromentin R, Takata H, Brehm J, Fukazawa Y, Randall B, et al. The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription. PLoS Pathog. 2022;18:e1010245 pubmed publisher
	Serra Peinado C, Grau Expósito J, Luque Ballesteros L, Astorga Gamaza A, Navarro J, Gallego Rodriguez J, et al. Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab. Nat Commun. 2019;10:3705 pubmed publisher
	Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, et al. A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity. Cell Host Microbe. 2019;26:114-122.e8 pubmed publisher
	McCracken M, Gromowski G, Friberg H, Lin X, Abbink P, De La Barrera R, et al. Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques. PLoS Pathog. 2017;13:e1006487 pubmed publisher
	Lubaki N, Younan P, Santos R, Meyer M, Iampietro M, Koup R, et al. The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses. PLoS Pathog. 2016;12:e1006031 pubmed publisher
	Lauterbach N, Crivello P, Wieten L, Zito L, Groeneweg M, Voorter C, et al. Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain. Mol Immunol. 2014;59:19-29 pubmed publisher
	Gonçalves R, Salmazi K, Santos B, Bastos M, Rocha S, Boscardin S, et al. CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?. Infect Immun. 2010;78:4763-72 pubmed publisher
	Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
	Fujita H, Nograles K, Kikuchi T, Gonzalez J, Carucci J, Krueger J. Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production. Proc Natl Acad Sci U S A. 2009;106:21795-800 pubmed publisher
	Zaba L, Cardinale I, Gilleaudeau P, Sullivan Whalen M, Suárez Fariñas M, Fuentes Duculan J, et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 2007;204:3183-94 pubmed

product information

Antigen :

HLA-DR

Apps. Abbrev. :

Flow Cytometry

Cat # :

307653

Clone :

L243

Item :

PE/Dazzle™ 594 anti-human HLA-DR

Isotype :

Mouse IgG2a, κ

Other Names :

Major Histocompatibility Class II, MHC class II

Size :

25 tests

Price (USD) :

141 USD

Reactivity :

Human, Cynomolgus, Rhesus

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PE_DZL594

Application Notes :

The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Clone L243 binds a conformational epitope on HLA-DRa which depends on the correct folding of the a heterodimer. 19 Additional reported applications (for the relevant formats) include: immunoprecipitation 8 , Western blotting 8 , in vitro blocking of mixed lymphocyte reactions 9,10 , depeletion of MHC class II cells 7 , immunohistochemical staining of acetone-fixed frozen sections 4,5 , and spatial biology (IBEX) 21,22 . For sensitive functional assays, we recommend using the Ultra-LEAF purified antibody (Endotoxin 0.01 EU/ug, Azide-Free, 0.2 um filtered) (Cat. No. 307648, 307665 - 307669).

more info or order :

BioLegend product webpage