product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Pacific Blue™ anti-human HLA-DR
catalog :
307624
quantity :
100 μg
price :
265 USD
clonality :
monoclonal
host :
mouse
conjugate :
Pacific Blue
clone name :
L243
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 23
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 3a
Crippa S, Rossella V, Aprile A, Silvestri L, Rivis S, Scaramuzza S, et al. Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity. J Clin Invest. 2019;129:1566-1580 pubmed publisher
  • flow cytometry; human; loading ...; fig s2d
Kong X, Martinez Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, et al. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018;19:973-985 pubmed publisher
  • flow cytometry; human; loading ...; fig 3b
Fujisaka Y, Iwata T, Tamai K, Nakamura M, Mochizuki M, Shibuya R, et al. Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif) ligand 2 and promotes proliferation of macrophages and myeloid-derived suppressor cells in hepatocellular carcinoma cell lines. Oncol Lett. 2018;15:509-514 pubmed publisher
  • flow cytometry; human; loading ...; tbl 2
van Erp F, Knol E, Pontoppidan B, Meijer Y, van der Ent C, Knulst A. The IgE and basophil responses to Ara h 2 and Ara h 6 are good predictors of peanut allergy in children. J Allergy Clin Immunol. 2017;139:358-360.e8 pubmed publisher
  • flow cytometry; human
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
Antonova L, Silnikov V, Sevostyanova V, Yuzhalin A, Koroleva L, Velikanova E, et al. Biocompatibility of Small-Diameter Vascular Grafts in Different Modes of RGD Modification. Polymers (Basel). 2019;11: pubmed publisher
Mello F, Land M, Costa E, Teodosio C, Sanchez M, Barcena P, et al. Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis. Cell Death Discov. 2019;5:69 pubmed publisher
Dulau Florea A, Young N, Maric I, Calvo K, Dunbar C, Townsley D, et al. Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection. Am J Clin Pathol. 2018;150:273-282 pubmed publisher
Garcia Montero A, Jara Acevedo M, Alvarez Twose I, Teodosio C, Sanchez Muñoz L, Muñiz C, et al. KIT D816V-mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression. Blood. 2016;127:761-8 pubmed publisher
Quast I, Cueni F, Nimmerjahn F, Tackenberg B, Lunemann J. Deregulated Fcγ receptor expression in patients with CIDP. Neurol Neuroimmunol Neuroinflamm. 2015;2:e148 pubmed publisher
Greer A, Matthay M, Kukreja J, Bhakta N, Nguyen C, Wolters P, et al. Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS ONE. 2014;9:e99084 pubmed publisher
Blish C, Dogan O, Jaoko W, McClelland R, Mandaliya K, Odem Davis K, et al. Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type 1 superinfection. J Virol. 2014;88:5894-9 pubmed publisher
de Vries R, Ludlow M, Verburgh R, van Amerongen G, Yüksel S, Nguyen D, et al. Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper virus. J Virol. 2014;88:4423-33 pubmed publisher
Bennett T, Montesinos P, Moscardo F, Martinez Cuadron D, Martinez J, Sierra J, et al. Pharmacological profiles of acute myeloid leukemia treatments in patient samples by automated flow cytometry: a bridge to individualized medicine. Clin Lymphoma Myeloma Leuk. 2014;14:305-18 pubmed publisher
Lauterbach N, Crivello P, Wieten L, Zito L, Groeneweg M, Voorter C, et al. Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain. Mol Immunol. 2014;59:19-29 pubmed publisher
Santos J, Barcia R, Simões S, Gaspar M, Calado S, Agua Doce A, et al. The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis. J Transl Med. 2013;11:18 pubmed publisher
Mesman A, de Vries R, McQuaid S, Duprex W, De Swart R, Geijtenbeek T. A prominent role for DC-SIGN+ dendritic cells in initiation and dissemination of measles virus infection in non-human primates. PLoS ONE. 2012;7:e49573 pubmed publisher
de Vries R, McQuaid S, van Amerongen G, Yüksel S, Verburgh R, Osterhaus A, et al. Measles immune suppression: lessons from the macaque model. PLoS Pathog. 2012;8:e1002885 pubmed publisher
Gonçalves R, Salmazi K, Santos B, Bastos M, Rocha S, Boscardin S, et al. CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?. Infect Immun. 2010;78:4763-72 pubmed publisher
Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
Fujita H, Nograles K, Kikuchi T, Gonzalez J, Carucci J, Krueger J. Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production. Proc Natl Acad Sci U S A. 2009;106:21795-800 pubmed publisher
Kuai J, Gregory B, Hill A, Pittman D, Feldman J, Brown T, et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford). 2009;48:1352-8 pubmed publisher
Zaba L, Cardinale I, Gilleaudeau P, Sullivan Whalen M, Suárez Fariñas M, Fuentes Duculan J, et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 2007;204:3183-94 pubmed
product information
Antigen :
HLA-DR
Apps. Abbrev. :
Flow Cytometry
Cat # :
307624
Clone :
L243
Item :
Pacific Blue™ anti-human HLA-DR
Isotype :
Mouse IgG2a, κ
Other Names :
Major Histocompatibility Class II, MHC class II
Size :
100 μg
Price (USD) :
265 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PB
Application Notes :
The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Clone L243 binds a conformational epitope on HLA-DRa which depends on the correct folding of the a heterodimer. 19 Additional reported applications (for the relevant formats) include: immunoprecipitation 8 , Western blotting 8 , in vitro blocking of mixed lymphocyte reactions 9,10 , depeletion of MHC class II cells 7 , immunohistochemical staining of acetone-fixed frozen sections 4,5 , and spatial biology (IBEX) 21,22 . For sensitive functional assays, we recommend using the Ultra-LEAF purified antibody (Endotoxin 0.01 EU/ug, Azide-Free, 0.2 um filtered) (Cat. No. 307648, 307665 - 307669).
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA