PE anti-human CD178 (FasL) | BioLegend 306406 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE anti-human CD178 (FasL)

catalog :

306406

quantity :

25 tests

price :

121 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

NOK-1

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 20

Reference
Hofmann L, Medyany V, Ezi x107 J, Lotfi R, Niesler B, R xf6 th R, et al. Cargo and Functional Profile of Saliva-Derived Exosomes Reveal Biomarkers Specific for Head and Neck Cancer. Front Med (Lausanne). 2022;9:904295 pubmed publisher
Contreras Ochoa C, Bahena Rom xe1 n M, L xf3 pez D xed az L, Lagunas Mart xed nez A, Mojica Cardoso C, Manzo Merino J, et al. Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping. Iran J Basic Med Sci. 2022;25:383-389 pubmed publisher
Beatson R, Parente Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al. TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Cell Rep Med. 2021;2:100473 pubmed publisher
Meng Q, Xie S, Gray G, Dezfulian M, Li W, Huang L, et al. Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids. J Immunother Cancer. 2021;9: pubmed publisher
Sulejmani O, Grunewald L, Andersch L, Schwiebert S, Klaus A, Winkler A, et al. Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis. Cancers (Basel). 2021;13: pubmed publisher
Van der Meer J, de Jonge P, van der Waart A, Geerlings A, Moonen J, Brummelman J, et al. CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice. Oncoimmunology. 2021;10:1981049 pubmed publisher
Afolabi L, Bi J, Li X, Adeshakin A, Adeshakin F, Wu H, et al. Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat. Front Immunol. 2021;12:701671 pubmed publisher
Wu J, Chen Z, Wickström S, Gao J, He X, Jing X, et al. Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism. Adv Sci (Weinh). 2021;8:e2101029 pubmed publisher
Meggyes M, Nagy D, Balassa T, Godony K, Peterfalvi A, Szereday L, et al. Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements. Biomolecules. 2021;11: pubmed publisher
Carri xf3 n B, Liu Y, Hadi M, Lundstrom J, Christensen J, Ammitzb xf8 ll C, et al. Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
Hagel J, Bennett K, Buffa F, Klenerman P, Willberg C, Powell K. Defining T Cell Subsets in Human Tonsils Using ChipCytometry. J Immunol. 2021;206:3073-3082 pubmed publisher
Lake C, Voss K, Bauman B, Pohida K, Jiang T, Dveksler G, et al. TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1. Cell Death Dis. 2021;12:400 pubmed publisher
Sch xf6 nberger S, Kraft D, Nettersheim D, Schorle H, Casati A, Craveiro R, et al. Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines. Cancers (Basel). 2020;12: pubmed publisher
Lamichhane R, Schneider M, de la Harpe S, Harrop T, Hannaway R, Dearden P, et al. TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses. Cell Rep. 2019;28:3061-3076.e5 pubmed publisher
Felices M, Lenvik A, McElmurry R, Chu S, Hinderlie P, Bendzick L, et al. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight. 2018;3: pubmed publisher
Fujii C, Kondo T, Ochi H, Okada Y, Hashi Y, Adachi T, et al. Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy. Sci Rep. 2016;6:35314 pubmed publisher
Wang Y, Wang X, Fan D, Zhang Y, Li M, Wu H, et al. PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A and TGF?2. J Endocrinol. 2014;222:151-60 pubmed publisher
Robinet P, Baychelier F, Fontaine T, Picard C, Debre P, Vieillard V, et al. A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells. J Immunol. 2014;192:5332-42 pubmed publisher
Medina M, Couturier J, Feske M, Mahne A, Turner M, Yu X, et al. Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells. J Leukoc Biol. 2012;91:759-71 pubmed publisher
Zhao Q, Guo Y, Feng B, Li L, Huang C, Jiao B. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82:735-41 pubmed publisher

product information

Antigen :

CD178

Apps. Abbrev. :

Cat # :

306406

Clone :

NOK-1

Item :

PE anti-human CD178 (FasL)

Isotype :

Mouse IgG1, κ

Other Names :

Fas Ligand (FasL), CD95L, TNFSF6, Fas-L

Size :

25 tests

Price (USD) :

121 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

Immunogen :

L5178Y mouse T lymphoma cells expressing recombinant human FasL

Application Notes :

Additional reported applications (for the relevant formats) include: immunoprecipitation^1,2, immunofluorescence microscopy^3, immunocytochemistry^2, blocking of Fas induced apoptosis^1, and Western blotting^11. Fas Ligand is expressed at low density on activated cells. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 306407) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 306404) or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)). In addition, applying matrix metalloproteinases (MMPS) inhibitor in the cell culture system will increase the FasL staining intensity. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 306415 and 306416).;

more info or order :

BioLegend product webpage