product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-human CD95 (Fas)
catalog :
305621
quantity :
25 tests
price :
153 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
DX2
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 21
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 3f, 3g
Fransen N, Crusius J, Smolders J, Mizee M, Van Eden C, Luchetti S, et al. Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms. Brain Pathol. 2020;30:106-119 pubmed publisher
  • flow cytometry; rhesus macaque; loading ...; fig 4
Berry N, Manoussaka M, Ham C, Ferguson D, Tudor H, Mattiuzzo G, et al. Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine. PLoS Pathog. 2016;12:e1006083 pubmed publisher
  • flow cytometry; human; loading ...; fig 1c
Keefer M, Zheng B, Rosenberg A, Kobie J. Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial. AIDS Res Hum Retroviruses. 2016;32:1143-1148 pubmed
  • flow cytometry; human; loading ...; fig 2c
Piepenbrink M, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, et al. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS ONE. 2016;11:e0158641 pubmed publisher
  • flow cytometry; human; fig 6
Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, et al. UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. Am J Hum Genet. 2015;96:221-34 pubmed publisher
  • flow cytometry; human
Kudernatsch R, Letsch A, Guerreiro M, Löbel M, Bauer S, Volk H, et al. Human bone marrow contains a subset of quiescent early memory CD8(+) T cells characterized by high CD127 expression and efflux capacity. Eur J Immunol. 2014;44:3532-42 pubmed publisher
Zebley C, Brown C, Mi T, Fan Y, Alli S, Boi S, et al. CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia. Cell Rep. 2021;37:110079 pubmed publisher
Zebley C, Abdelsamed H, Ghoneim H, Alli S, Brown C, Haydar D, et al. Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation. Cell Rep. 2021;37:109796 pubmed publisher
Smith C, McGrath M, Neller M, Matthews K, Crooks P, Le Texier L, et al. Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma. NPJ Precis Oncol. 2021;5:24 pubmed publisher
Corrado M, Edwards Hicks J, Villa M, Flachsmann L, Sanin D, Jacobs M, et al. Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metab. 2020;32:981-995.e7 pubmed publisher
Pais Ferreira D, Silva J, Wyss T, Fuertes Marraco S, Scarpellino L, Charmoy M, et al. Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation. Immunity. 2020;53:985-1000.e11 pubmed publisher
Bovay A, Speiser D, Fuertes Marraco S. Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination. Hum Vaccin Immunother. 2020;16:3103-3110 pubmed publisher
Shukla V, Halabelian L, Balagere S, Samaniego Castruita D, Feldman D, Arrowsmith C, et al. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Mol Cell. 2020;77:384-394.e4 pubmed publisher
Cassetta L, Fragkogianni S, Sims A, Swierczak A, Forrester L, Zhang H, et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell. 2019;35:588-602.e10 pubmed publisher
Siddiqui I, Schaeuble K, Chennupati V, Fuertes Marraco S, Calderon Copete S, Pais Ferreira D, et al. Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity. 2019;50:195-211.e10 pubmed publisher
Felices M, Lenvik A, McElmurry R, Chu S, Hinderlie P, Bendzick L, et al. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight. 2018;3: pubmed publisher
Fitzsimmons L, Boyce A, Wei W, Chang C, Croom Carter D, Tierney R, et al. Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells. Cell Death Differ. 2018;25:241-254 pubmed publisher
Domeier P, Chodisetti S, Soni C, Schell S, Elias M, Wong E, et al. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med. 2016;213:715-32 pubmed publisher
Marco M, Dons E, van der Windt D, Bhama J, Lu L, Zahorchak A, et al. Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in heart-transplanted cynomolgus monkeys. Transpl Immunol. 2013;29:88-98 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Xie S, Li J, Wang J, Wu Q, Yang P, Hsu H, et al. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J Immunol. 2010;184:2289-96 pubmed publisher
product information
Antigen :
CD95
Apps. Abbrev. :
FC
Cat # :
305621
Clone :
DX2
Item :
PE/Cyanine7 anti-human CD95 (Fas)
Isotype :
Mouse IgG1, κ
Other Names :
Fas, APO-1, TNFRSF6
Size :
25 tests
Price (USD) :
153 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE_CYANINE7
Immunogen :
CD95 transfected L cells
Application Notes :
The DX2 antibody is useful for inducing apoptosis of Fas-positive cells. Additional reported applications (for the relevant formats) include: in vitro induction of apoptosis^3 (DX2 antibody is required to be cross-linked for effective induction of apoptosis) and immunohistochemical staining^4,5 of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 305655 and 305656).Note: EOS9.1 antibody can induce apoptosis without cross-linking.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA