product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD95 (Fas)
catalog :
305611
quantity :
25 tests
price :
159 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
DX2
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 24
Reference
Imai H, Kawase T, Yoshida S, Mese T, Roh S, Fujita A, et al. Peripheral T cell profiling reveals downregulated exhaustion marker and increased diversity in lymphedema post-lymphatic venous anastomosis. iScience. 2023;26:106822 pubmed publisher
Afsahi A, Silvestri C, Moore A, Graham C, Bacchiochi K, St Jean M, et al. LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling. Front Immunol. 2023;14:1179827 pubmed publisher
Cao B, Liu M, Wang L, Zhu K, Cai M, Chen X, et al. Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer. Nat Commun. 2022;13:6203 pubmed publisher
Vazquez Lombardi R, Jung J, Schlatter F, Mei A, Mantuano N, Bieberich F, et al. High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity. Immunity. 2022;55:1953-1966.e10 pubmed publisher
Perdigoto A, Deng S, Du K, Kuchroo M, Burkhardt D, Tong A, et al. Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes. JCI Insight. 2022;7: pubmed publisher
Rhoades N, Davies M, Lewis S, Cinco I, Kohama S, Bermudez L, et al. Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques. Cell Rep. 2022;39:110725 pubmed publisher
Wang D, Xiu J, Zhao J, Luo J. miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level. EMBO Rep. 2022;23:e53691 pubmed publisher
Sulejmani O, Grunewald L, Andersch L, Schwiebert S, Klaus A, Winkler A, et al. Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis. Cancers (Basel). 2021;13: pubmed publisher
Fu Y, Zhang Z, Yang Z, Jiang Y, Han X, Xu J, et al. CD27-CD38+ B cells accumulated in early HIV infection exhibit transitional profile and promote HIV disease progression. Cell Rep. 2021;36:109344 pubmed publisher
Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
Chang X, Webb G, Wu H, Greene J, Abdulhaqq S, Bateman K, et al. Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission. Nat Commun. 2021;12:3343 pubmed publisher
Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020;183:1496-1507.e16 pubmed publisher
Aalam F, Nabiee R, Castano J, Totonchy J. Analysis of KSHV B lymphocyte lineage tropism in human tonsil reveals efficient infection of CD138+ plasma cells. PLoS Pathog. 2020;16:e1008968 pubmed publisher
He P, Tan Z, Wei Z, Wan C, Yang S. Co-expressing LRP6 With Anti-CD19 CAR-T Cells for Improved Therapeutic Effect Against B-ALL. Front Oncol. 2020;10:1346 pubmed publisher
Alter G, Yu W, Chandrashekar A, Borducchi E, Ghneim K, Sharma A, et al. Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques. Cell. 2020;183:185-196.e14 pubmed publisher
Toews K, Grunewald L, Schwiebert S, Klaus A, Winkler A, Ali S, et al. Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells. Mol Carcinog. 2020;59:724-735 pubmed publisher
Kulshrestha A, Katara G, Ibrahim S, Riehl V, Sahoo M, Dolan J, et al. Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway. J Oncol. 2019;2019:2343876 pubmed publisher
de Jonge K, Ebering A, Nassiri S, Maby El Hajjami H, Ouertatani Sakouhi H, Baumgaertner P, et al. Circulating CD56bright NK cells inversely correlate with survival of melanoma patients. Sci Rep. 2019;9:4487 pubmed publisher
Aldeghaither D, Zahavi D, Murray J, Fertig E, Graham G, Zhang Y, et al. A Mechanism of Resistance to Antibody-Targeted Immune Attack. Cancer Immunol Res. 2019;7:230-243 pubmed publisher
Backes C, Friedmann K, Mang S, Knörck A, Hoth M, Kummerow C. Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms. J Biol Chem. 2018;293:16348-16363 pubmed publisher
Hu X, Tai J, Qu Z, Zhao S, Zhang L, Li M, et al. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. PLoS ONE. 2016;11:e0152368 pubmed publisher
Paschall A, Yang D, Lu C, Choi J, Li X, Liu F, et al. H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance. J Immunol. 2015;195:1868-82 pubmed publisher
Wang Y, Wang X, Fan D, Zhang Y, Li M, Wu H, et al. PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A and TGF?2. J Endocrinol. 2014;222:151-60 pubmed publisher
Zizzo G, Cohen P. IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol. 2013;190:5237-46 pubmed publisher
product information
Antigen :
CD95
Apps. Abbrev. :
FC
Cat # :
305611
Clone :
DX2
Item :
APC anti-human CD95 (Fas)
Isotype :
Mouse IgG1, κ
Other Names :
Fas, APO-1, TNFRSF6
Size :
25 tests
Price (USD) :
159 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
CD95 transfected L cells
Application Notes :
The DX2 antibody is useful for inducing apoptosis of Fas-positive cells. Additional reported applications (for the relevant formats) include: in vitro induction of apoptosis^3 (DX2 antibody is required to be cross-linked for effective induction of apoptosis) and immunohistochemical staining^4,5 of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 305655 and 305656).Note: EOS9.1 antibody can induce apoptosis without cross-linking.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA