product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD86
catalog :
305411
quantity :
25 tests
price :
149 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
IT2.2
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 3c
Celis Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Gregoire C, et al. Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy. Cell Rep. 2019;27:3315-3330.e7 pubmed publisher
  • flow cytometry; human; fig 6
Rancan C, Schirrmann L, Hüls C, Zeidler R, Moosmann A. Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells. PLoS Pathog. 2015;11:e1004906 pubmed publisher
  • flow cytometry; human; loading ...; fig 4d
Duggal N, Beswetherick A, Upton J, Hampson P, Phillips A, Lord J. Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production. Exp Gerontol. 2014;54:27-34 pubmed publisher
Rodriguez Perdigon M, Haeni L, Rothen Rutishauser B, R xfc egg C. Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model. Front Bioeng Biotechnol. 2023;11:1159819 pubmed publisher
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, et al. DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. EMBO J. 2022;:e111961 pubmed publisher
Xu G, Niu L, Wang Y, Yang G, Zhu X, Yao Y, et al. HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer. Cell Death Dis. 2022;13:888 pubmed publisher
Perera M, Sinclair J. The Human Cytomegalovirus β2.7 Long Non-Coding RNA Prevents Induction of Reactive Oxygen Species to Maintain Viral Gene Silencing during Latency. Int J Mol Sci. 2022;23: pubmed publisher
Csomós K, Ujhazi B, Blazso P, Herrera J, Tipton C, Kawai T, et al. Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. Nat Immunol. 2022;23:1256-1272 pubmed publisher
Amo L, D xed ez Garc xed a J, Tamayo Orbegozo E, Maruri N, Larrucea S. Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site. Front Immunol. 2022;13:835527 pubmed publisher
Zhu F, Teng Z, Zhou X, Xu R, Bing X, Shi L, et al. H1N1 Influenza Virus-Infected Nasal Mucosal Epithelial Progenitor Cells Promote Dendritic Cell Recruitment and Maturation. Front Immunol. 2022;13:879575 pubmed publisher
Tu J, Tan X, Chen Y, Li Z, Zhang Y, Chen X, et al. Growth arrest-specific transcript 5 represses endometrial cancer development by promoting antitumor function of tumor-associated macrophages. Cancer Sci. 2022;113:2496-2512 pubmed publisher
Arcangeli S, Bove C, Mezzanotte C, Camisa B, Falcone L, Manfredi F, et al. CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome. J Clin Invest. 2022;132: pubmed publisher
Vereertbrugghen A, Colado A, Gargiulo E, Bezares R, Fernández Grecco H, Cordini G, et al. In Vitro Sensitivity to Venetoclax and Microenvironment Protection in Hairy Cell Leukemia. Front Oncol. 2021;11:598319 pubmed publisher
Pinto S, Kim H, Subbannayya Y, Giambelluca M, B xf6 sl K, Ryan L, et al. Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation. Front Immunol. 2021;12:679458 pubmed publisher
Papalexi E, Mimitou E, Butler A, Foster S, Bracken B, Mauck W, et al. Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens. Nat Genet. 2021;53:322-331 pubmed publisher
Muto S, Ozaki Y, Yamaguchi H, Mine H, Takagi H, Watanabe M, et al. Tumor β-catenin expression is associated with immune evasion in non-small cell lung cancer with high tumor mutation burden. Oncol Lett. 2021;21:203 pubmed publisher
Chometon T, Siqueira M, Sant Anna J, Almeida M, Gandini M, Martins de Almeida Nogueira A, et al. A protocol for rapid monocyte isolation and generation of singular human monocyte-derived dendritic cells. PLoS ONE. 2020;15:e0231132 pubmed publisher
Kim S, Hwang J, Kim Y, Lee H. Heterogeneity of porcine bone marrow-derived dendritic cells induced by GM-CSF. PLoS ONE. 2019;14:e0223590 pubmed publisher
Ong S, Teng K, Newell E, Chen H, Chen J, Loy T, et al. A Novel, Five-Marker Alternative to CD16-CD14 Gating to Identify the Three Human Monocyte Subsets. Front Immunol. 2019;10:1761 pubmed publisher
Cassetta L, Fragkogianni S, Sims A, Swierczak A, Forrester L, Zhang H, et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell. 2019;35:588-602.e10 pubmed publisher
Castellaro A, Rodriguez Baili M, Di Tada C, Gil G. Tumor-Associated Macrophages Induce Endocrine Therapy Resistance in ER+ Breast Cancer Cells. Cancers (Basel). 2019;11: pubmed publisher
Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin A, Brinkert K, et al. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections. Nat Commun. 2018;9:5088 pubmed publisher
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
Hazeldine J, Naumann D, Toman E, Davies D, Bishop J, Su Z, et al. Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study. PLoS Med. 2017;14:e1002338 pubmed publisher
Longbrake E, Cantoni C, Chahin S, Cignarella F, Cross A, Piccio L. Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count. Mult Scler. 2018;24:728-738 pubmed publisher
Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed publisher
Kotsiou E, Okosun J, Besley C, Iqbal S, Matthews J, Fitzgibbon J, et al. TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses. Blood. 2016;128:72-81 pubmed publisher
Hu X, Tai J, Qu Z, Zhao S, Zhang L, Li M, et al. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. PLoS ONE. 2016;11:e0152368 pubmed publisher
Nastasi C, Candela M, Bonefeld C, Geisler C, Hansen M, Krejsgaard T, et al. The effect of short-chain fatty acids on human monocyte-derived dendritic cells. Sci Rep. 2015;5:16148 pubmed publisher
Nowak A, Cook A, McDonnell A, Millward M, Creaney J, Francis R, et al. A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma. Ann Oncol. 2015;26:2483-90 pubmed publisher
Herath S, Benlahrech A, Papagatsias T, Athanasopoulos T, Bouzeboudjen Z, Hervouet C, et al. Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses. PLoS ONE. 2014;9:e88327 pubmed publisher
product information
Antigen :
CD86
Apps. Abbrev. :
FC
Cat # :
305411
Clone :
IT2.2
Item :
APC anti-human CD86
Isotype :
Mouse IgG2b, κ
Other Names :
B7-2, B70
Size :
25 tests
Price (USD) :
149 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections^6, Western blotting^3, and blocking of T cell activation^2,4,5. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 305449 & 305450).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA