product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human CD66b
catalog :
305102
quantity :
100 μg
price :
114 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G10F5
reactivity :
human
application :
immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 67
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Amaral E, Foreman T, Namasivayam S, Hilligan K, Kauffman K, Barbosa Bomfim C, et al. GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. J Exp Med. 2022;219: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 3b
Lagnado A, Leslie J, Ruchaud Sparagano M, Victorelli S, Hirsova P, Ogrodnik M, et al. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 2021;40:e106048 pubmed publisher
  • flow cytometry; human; 5:50; loading ...; fig 3s2d
Gregorova M, Morse D, Brignoli T, Steventon J, Hamilton F, Albur M, et al. Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia. elife. 2020;9: pubmed publisher
  • flow cytometry; human; loading ...; fig s2d
Martin J, Chang C, Boschetti G, Ungaro R, Giri M, Grout J, et al. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019;178:1493-1508.e20 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Swaims Kohlmeier A, Haddad L, Li Z, Brookmeyer K, Baker J, Widom C, et al. Chronic immune barrier dysregulation among women with a history of violence victimization. JCI Insight. 2019;4: pubmed publisher
  • flow cytometry; human; 1:100; loading ...; fig 3s1a
Spolski R, West E, Li P, Veenbergen S, Yung S, Kazemian M, et al. IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus. elife. 2019;8: pubmed publisher
  • flow cytometry; human; loading ...; fig s3a
Tamassia N, Arruda Silva F, Calzetti F, Lonardi S, Gasperini S, Gardiman E, et al. A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It. Front Immunol. 2018;9:795 pubmed publisher
  • flow cytometry; human; loading ...; fig s4a
See P, Dutertre C, Chen J, Günther P, McGovern N, Irac S, et al. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017;356: pubmed publisher
  • flow cytometry; human; loading ...; fig 3c
Zhang J, Xu X, Shi M, Chen Y, Yu D, Zhao C, et al. CD13hi Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma. Oncoimmunology. 2017;6:e1258504 pubmed publisher
  • flow cytometry; human; fig s5a
Lood C, Blanco L, Purmalek M, Carmona Rivera C, De Ravin S, Smith C, et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med. 2016;22:146-53 pubmed publisher
  • flow cytometry; human; 1:100
Lee J, Breton G, Aljoufi A, Zhou Y, PUHR S, Nussenzweig M, et al. Clonal analysis of human dendritic cell progenitor using a stromal cell culture. J Immunol Methods. 2015;425:21-6 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, et al. Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer. Cancer Res. 2015;75:2629-40 pubmed publisher
  • flow cytometry; human; fig 2
Anandasabapathy N, Breton G, Hurley A, Caskey M, Trumpfheller C, Sarma P, et al. Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015;50:924-30 pubmed publisher
  • flow cytometry; human; fig 4
Weldon A, Moldovan I, Cabling M, Hernandez E, Hsu S, Gonzalez J, et al. Surface APRIL Is Elevated on Myeloid Cells and Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. J Rheumatol. 2015;42:749-59 pubmed publisher
  • flow cytometry; human; fig 1
Lee J, Breton G, Oliveira T, Zhou Y, Aljoufi A, PUHR S, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212:385-99 pubmed publisher
  • flow cytometry; human; fig 5
  • immunocytochemistry; human; fig 6
Meinke P, Schneiderat P, Srsen V, Korfali N, Lê Thành P, Cowan G, et al. Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy. Neuromuscul Disord. 2015;25:127-36 pubmed publisher
Chen J, Yang P, Li S, Feng Y. Increased FOXM1 Expression was Associated with the Prognosis and the Recruitment of Neutrophils in Endometrial Cancer. J Immunol Res. 2023;2023:5437526 pubmed publisher
Thiriard A, Meyer B, Eberhardt C, Loevy N, Grazioli S, Adouan W, et al. Antibody response in children with multisystem inflammatory syndrome related to COVID-19 (MIS-C) compared to children with uncomplicated COVID-19. Front Immunol. 2023;14:1107156 pubmed publisher
Poon M, Caron D, Wang Z, Wells S, Chen D, Meng W, et al. Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nat Immunol. 2023;24:309-319 pubmed publisher
Yu J, Thomas P, McMahan K, Jacob Dolan C, Liu J, He X, et al. Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Sci Adv. 2022;8:eade4433 pubmed publisher
Tiberti S, Catozzi C, Croci O, Ballerini M, Cagnina D, Soriani C, et al. GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome. Nat Commun. 2022;13:6752 pubmed publisher
Xu L, GUO J, Moledina D, Cantley L. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nat Commun. 2022;13:4892 pubmed publisher
Schloss M, Hulsmans M, Rohde D, Lee I, Severe N, Foy B, et al. B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nat Immunol. 2022;23:605-618 pubmed publisher
Valet C, Magnen M, Qiu L, Cleary S, Wang K, Ranucci S, et al. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022;132: pubmed publisher
Schimek V, Strasser K, Beer A, Göber S, Walterskirchen N, Brostjan C, et al. Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment. Cell Death Dis. 2022;13:113 pubmed publisher
Aymonnier K, Ng J, Fredenburgh L, Zambrano Vera K, Münzer P, Gutch S, et al. Inflammasome activation in neutrophils of patients with severe COVID-19. Blood Adv. 2022;6:2001-2013 pubmed publisher
Leader A, Grout J, Maier B, Nabet B, Park M, Tabachnikova A, et al. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell. 2021;39:1594-1609.e12 pubmed publisher
Xu G, Li Y, Zhang S, Peng H, Wang Y, Li D, et al. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Res. 2021;31:1230-1243 pubmed publisher
Pelka K, Hofree M, Chen J, Sarkizova S, Pirl J, Jorgji V, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021;184:4734-4752.e20 pubmed publisher
Taft J, Markson M, Legarda D, Patel R, Chan M, Malle L, et al. Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell. 2021;184:4447-4463.e20 pubmed publisher
Arunachalam P, Scott M, Hagan T, Li C, Feng Y, Wimmers F, et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021;596:410-416 pubmed publisher
Oh J, Carlson J, Landeros C, Lee H, Ferguson S, Faquin W, et al. Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling. Clin Cancer Res. 2021;27:4781-4793 pubmed publisher
Debien V, Davidson G, Baltzinger P, Kurtz J, S xe9 verac F, Imperiale A, et al. Involvement of Neutrophils in Metastatic Evolution of Pancreatic Neuroendocrine Tumors. Cancers (Basel). 2021;13: pubmed publisher
Bartsch Y, Loos C, Rossignol E, Fajnzylber J, Yuan D, Avihingsanon A, et al. Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. MBio. 2021;12: pubmed publisher
Yu K, Fischinger S, Smith M, Atyeo C, Cizmeci D, Wolf C, et al. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021;6: pubmed publisher
Tran A, Diogo G, Paul M, Copland A, Hart P, Mehta N, et al. Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ. Front Immunol. 2020;11:582833 pubmed publisher
Fischinger S, Dolatshahi S, Jennewein M, Rerks Ngarm S, Pitisuttithum P, Nitayaphan S, et al. IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees. JCI Insight. 2020;5: pubmed publisher
Li H, Wu H, Guo Q, Yu H, Xu Y, Yu J, et al. Myeloid-Derived Suppressor Cells Promote the Progression of Primary Membranous Nephropathy by Enhancing Th17 Response. Front Immunol. 2020;11:1777 pubmed publisher
van der Poel M, Hoepel W, Hamann J, Huitinga I, Dunnen J. IgG Immune Complexes Break Immune Tolerance of Human Microglia. J Immunol. 2020;205:2511-2518 pubmed publisher
Leylek R, Alcántara Hernández M, Granja J, Chavez M, Perez K, Diaz O, et al. Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity. Cell Rep. 2020;32:108180 pubmed publisher
Mann E, Menon M, Knight S, Konkel J, Jagger C, Shaw T, et al. Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19. Sci Immunol. 2020;5: pubmed publisher
Ehinger E, Ghosheh Y, Pramod A, Lin J, Hanna D, Mueller K, et al. Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV. Cardiovasc Res. 2021;117:1166-1177 pubmed publisher
Weinhage T, K xf6 lsche T, Rieger Fackeldey E, Schmitz R, Antoni A, Ahlmann M, et al. Cord Blood Low-Density Granulocytes Correspond to an Immature Granulocytic Subset with Low Expression of S100A12. J Immunol. 2020;205:56-66 pubmed publisher
De Maeyer R, van de Merwe R, Louie R, Bracken O, Devine O, Goldstein D, et al. Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly. Nat Immunol. 2020;21:615-625 pubmed publisher
Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco K, Connolly E, et al. Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. Cell Rep. 2020;30:2209-2224.e5 pubmed publisher
Stras S, Werner L, Toothaker J, Olaloye O, Oldham A, McCourt C, et al. Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development. Dev Cell. 2019;51:357-373.e5 pubmed publisher
Ma W, Lee J, Backenroth D, Zhou Y, Bush E, Sims P, et al. Single cell RNA-Seq reveals pre-cDCs fate determined by transcription factor combinatorial dose. BMC Mol Cell Biol. 2019;20:20 pubmed publisher
ELDREDGE L, Creasy R, Presnell S, Debley J, Juul S, Mayock D, et al. Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates. Am J Physiol Lung Cell Mol Physiol. 2019;317:L49-L56 pubmed publisher
Franco L, Gadkari M, Howe K, Sun J, Kardava L, Kumar P, et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019;216:384-406 pubmed publisher
Keskin D, Anandappa A, Sun J, Tirosh I, Mathewson N, Li S, et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019;565:234-239 pubmed publisher
Kimble J, Malherbe D, Meyer M, Gunn B, Karim M, Ilinykh P, et al. Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine. J Virol. 2019;93: pubmed publisher
Ilinykh P, Santos R, Gunn B, Kuzmina N, Shen X, Huang K, et al. Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. PLoS Pathog. 2018;14:e1007204 pubmed publisher
Gilchuk P, Kuzmina N, Ilinykh P, Huang K, Gunn B, Bryan A, et al. Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity. 2018;49:363-374.e10 pubmed publisher
Martin A, Seignez C, Racoeur C, Isambert N, Mabrouk N, Scagliarini A, et al. Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment. Oncotarget. 2018;9:28364-28378 pubmed publisher
Arnold I, Artola Borán M, Tallón de Lara P, Kyburz A, Taube C, OTTEMANN K, et al. Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation. J Exp Med. 2018;215:2055-2072 pubmed publisher
Cao Q, Wang Y, Wang C, Wang X, Lee V, Zheng G, et al. Therapeutic potential of regulatory macrophages generated from peritoneal dialysate in adriamycin nephropathy. Am J Physiol Renal Physiol. 2018;314:F561-F571 pubmed publisher
Miyamoto D, Lee R, Kalinich M, LiCausi J, Zheng Y, Chen T, et al. An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer. Cancer Discov. 2018;8:288-303 pubmed publisher
Fry T, Shah N, Orentas R, Stetler Stevenson M, Yuan C, Ramakrishna S, et al. CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nat Med. 2018;24:20-28 pubmed publisher
Stojkov D, Amini P, Oberson K, Sokollik C, Duppenthaler A, Simon H, et al. ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation. J Cell Biol. 2017;216:4073-4090 pubmed publisher
Nirschl C, Suárez Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, et al. IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017;170:127-141.e15 pubmed publisher
Barrera L, Montes Servín E, Hernandez Martinez J, García Vicente M, Montes Servín E, Herrera Martínez M, et al. CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients. Br J Cancer. 2017;117:385-397 pubmed publisher
Patel A, Zhang Y, Fullerton J, Boelen L, Rongvaux A, Maini A, et al. The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. J Exp Med. 2017;214:1913-1923 pubmed publisher
Lavin Y, Kobayashi S, Leader A, Amir E, Elefant N, Bigenwald C, et al. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell. 2017;169:750-765.e17 pubmed publisher
Jimenez Flores E, Tian S, Sizova M, Epstein S, Lamont R, Uriarte S. Peptoanaerobacter stomatis Primes Human Neutrophils and Induces Granule Exocytosis. Infect Immun. 2017;85: pubmed publisher
Governa V, Trella E, Mele V, Tornillo L, Amicarella F, Cremonesi E, et al. The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer. Clin Cancer Res. 2017;23:3847-3858 pubmed publisher
Davis R, Sharma S, Conceição J, Carneiro P, Novais F, Scott P, et al. Phenotypic and functional characteristics of HLA-DR+ neutrophils in Brazilians with cutaneous leishmaniasis. J Leukoc Biol. 2017;101:739-749 pubmed publisher
Norling L, Dalli J, Flower R, Serhan C, Perretti M. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol. 2012;32:1970-8 pubmed publisher
product information
Antigen :
CD66b
Apps. Abbrev. :
FC, IHC-P
Cat # :
305102
Clone :
G10F5
Item :
Purified anti-human CD66b
Isotype :
Mouse IgM, κ
Other Names :
CD67, CGM6, NCA-95, CEACAM8
Size :
100 μg
Price (USD) :
114 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen, formalin-fixed paraffin-embedded tissue sections, and spatial biology (IBEX)^5,6.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA