product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD62L
catalog :
304809
quantity :
25 tests
price :
150 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
DREG-56
reactivity :
human
application :
flow cytometry
more info or order :
citations: 28
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1c
Vavassori V, Mercuri E, Marcovecchio G, Castiello M, Schiroli G, Albano L, et al. Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome. EMBO Mol Med. 2021;13:e13545 pubmed publisher
  • flow cytometry; human; fig 4
O Carroll S, Kho D, Wiltshire R, Nelson V, Rotimi O, Johnson R, et al. Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. J Neuroinflammation. 2015;12:131 pubmed publisher
Zhang B, Sun J, Yuan Y, Ji D, Sun Y, Liu Y, et al. Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity. Signal Transduct Target Ther. 2023;8:28 pubmed publisher
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, et al. Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. Nature. 2022;609:369-374 pubmed publisher
Arasanz H, Bocanegra A, Morilla I, Fern xe1 ndez Irigoyen J, Mart xed nez Aguillo M, Teijeira L, et al. Circulating Low Density Neutrophils Are Associated with Resistance to First Line Anti-PD1/PDL1 Immunotherapy in Non-Small Cell Lung Cancer. Cancers (Basel). 2022;14: pubmed publisher
Zhou Z, Yan X, Shi W, Tan K, Shao C, Wang Y, et al. Evaluation of the tumoricidal efficacy of adoptive cell transfer using hepatocellular carcinoma-derived organoids. J Gastrointest Oncol. 2022;13:732-743 pubmed publisher
Arcangeli S, Bove C, Mezzanotte C, Camisa B, Falcone L, Manfredi F, et al. CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome. J Clin Invest. 2022;132: pubmed publisher
Bonte S, De Munter S, Billiet L, Goetgeluk G, Ingels J, Jansen H, et al. In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality. Oncoimmunology. 2021;10:1954800 pubmed publisher
Mishra H, Dixon K, Pore N, Felices M, Miller J, Walcheck B. Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation. Front Immunol. 2021;12:711621 pubmed publisher
Blanco Camarillo C, Alemán O, Rosales C. Low-Density Neutrophils in Healthy Individuals Display a Mature Primed Phenotype. Front Immunol. 2021;12:672520 pubmed publisher
Alhaj Hussen K, Michonneau D, Biajoux V, Keita S, Dubouchet L, Nelson E, et al. CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease. Front Immunol. 2020;11:579776 pubmed publisher
Cao M, Ruan L, Huang Y, Wang J, Yan J, Sang Y, et al. Premature CD4+ T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome. Aging Dis. 2020;11:1471-1480 pubmed publisher
Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020;53:658-671.e6 pubmed publisher
Xu P, Tang K, Ma J, Zhang H, Wang D, Zhu L, et al. Chemotherapeutic Tumor Microparticles Elicit a Neutrophil Response Targeting Malignant Pleural Effusions. Cancer Immunol Res. 2020;8:1193-1205 pubmed publisher
Hally K, Bird G, La Flamme A, Harding S, Larsen P. Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation. PLoS ONE. 2019;14:e0223444 pubmed publisher
Collinson Pautz M, Chang W, Lu A, Khalil M, Crisostomo J, Lin P, et al. Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies. Leukemia. 2019;: pubmed publisher
Corleis B, Bucşan A, Deruaz M, Vrbanac V, Lisanti Park A, Gates S, et al. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis. Cell Rep. 2019;26:1409-1418.e5 pubmed publisher
Idorn M, Olsen M, Halldórsdóttir H, Skadborg S, Pedersen M, Høgdall C, et al. Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction. Oncoimmunology. 2018;7:e1412029 pubmed publisher
Alflen A, Stadler N, Aranda Lopez P, Teschner D, Theobald M, Heß G, et al. Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses. Sci Rep. 2018;8:5558 pubmed publisher
Alhaj Hussen K, Vu Manh T, Guimiot F, Nelson E, Chabaane E, Delord M, et al. Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis. Immunity. 2017;47:680-696.e8 pubmed publisher
Hale M, Lee B, Honaker Y, Leung W, Grier A, Jacobs H, et al. Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells. Mol Ther Methods Clin Dev. 2017;4:192-203 pubmed publisher
Nakajima Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, et al. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS ONE. 2017;12:e0172795 pubmed publisher
Lieberman L, Zeng W, Singh C, Wang W, Otipoby K, Loh C, et al. CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients. Neurology. 2016;86:375-81 pubmed publisher
Inglis H, Norris P, Danesh A. Techniques for the analysis of extracellular vesicles using flow cytometry. J Vis Exp. 2015;: pubmed publisher
Hünniger K, Bieber K, Martin R, Lehnert T, Figge M, Löffler J, et al. A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. J Immunol. 2015;194:1199-210 pubmed publisher
Trinité B, Chan C, Lee C, Mahajan S, Luo Y, Muesing M, et al. Suppression of Foxo1 activity and down-modulation of CD62L (L-selectin) in HIV-1 infected resting CD4 T cells. PLoS ONE. 2014;9:e110719 pubmed publisher
Jin C, Ekwall A, Bylund J, Björkman L, Estrella R, Whitelock J, et al. Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity. J Biol Chem. 2012;287:35922-33 pubmed publisher
Ryba M, Marek N, Hak Ł, Rybarczyk Kapturska K, Myśliwiec M, Trzonkowski P, et al. Anti-TNF rescue CD4+Foxp3+ regulatory T cells in patients with type 1 diabetes from effects mediated by TNF. Cytokine. 2011;55:353-61 pubmed publisher
product information
Antigen :
CD62L
Apps. Abbrev. :
FC
Cat # :
304809
Clone :
DREG-56
Item :
APC anti-human CD62L
Isotype :
Mouse IgG1, κ
Other Names :
L-selectin, LECAM-1, LAM-1, Leu-8, TQ-1
Size :
25 tests
Price (USD) :
150 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
Concentrated supernatant from PMA-activated human peripheral blood leukocytes
Application Notes :
Additional reported applications (for the relevant formats) include: Western blotting^2,3,9 and in vitro blocking of lymphocytes binding to high endothelial venules (HEV)^2. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 304853-304858).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA