product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-human CD45RA
catalog :
304130
quantity :
100 tests
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV421
clone name :
HI100
reactivity :
human
application :
western blot, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:100; loading ...; fig 3a
Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez S, Dan J, et al. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. 2020;370:89-94 pubmed publisher
  • flow cytometry; human
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
Mo Y, To K, Zhou R, Liu L, Cao T, Huang H, et al. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2021;12:799896 pubmed publisher
Xu S, Chaudhary O, Rodríguez Morales P, Sun X, Chen D, Zappasodi R, et al. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021;54:1561-1577.e7 pubmed publisher
Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, et al. CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability. Cell Metab. 2021;33:1001-1012.e5 pubmed publisher
Sekine T, Perez Potti A, Rivera Ballesteros O, Stralin K, Gorin J, Olsson A, et al. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. Cell. 2020;183:158-168.e14 pubmed publisher
Penkava F, Velasco Herrera M, Young M, Yager N, Nwosu L, Pratt A, et al. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat Commun. 2020;11:4767 pubmed publisher
Sagnella S, Yang L, Stubbs G, Boslem E, Martino Echarri E, Smolarczyk K, et al. Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells. Cancer Cell. 2020;37:354-370.e7 pubmed publisher
Celik H, Koh W, Kramer A, Ostrander E, Mallaney C, Fisher D, et al. JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell. 2018;34:741-756.e8 pubmed publisher
Claireaux M, Galperin M, Benati D, Nouel A, Mukhopadhyay M, Klingler J, et al. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers. MBio. 2018;9: pubmed publisher
Lichtenegger F, Rothe M, Schnorfeil F, Deiser K, Krupka C, Augsberger C, et al. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells. Front Immunol. 2018;9:385 pubmed publisher
Carisey A, Mace E, Saeed M, Davis D, Orange J. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018;28:489-502.e9 pubmed publisher
Mukhopadhyay M, Galperin M, Patgaonkar M, Vasan S, Ho D, Nouël A, et al. DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol. 2017;199:3437-3452 pubmed publisher
Balakrishnan A, Gloude N, Sasik R, Ball E, Morris G. Proinflammatory Dual Receptor T Cells in Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23:1852-1860 pubmed publisher
Sckisel G, Mirsoian A, Minnar C, Crittenden M, Curti B, Chen J, et al. Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy. J Immunother Cancer. 2017;5:33 pubmed publisher
de Graav G, Hesselink D, Dieterich M, Kraaijeveld R, Weimar W, Baan C. Down-Regulation of Surface CD28 under Belatacept Treatment: An Escape Mechanism for Antigen-Reactive T-Cells. PLoS ONE. 2016;11:e0148604 pubmed publisher
Ryan J, Hovde R, Glanville J, Lyu S, Ji X, Gupta S, et al. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci U S A. 2016;113:E1286-95 pubmed publisher
Ward D, Carter D, Homer M, Marucci L, Gampel A. Mathematical modeling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture. Haematologica. 2016;101:286-96 pubmed publisher
Li Causi E, Parikh S, Chudley L, Layfield D, Ottensmeier C, Stevenson F, et al. Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells. PLoS ONE. 2015;10:e0136717 pubmed publisher
Thommen D, Schreiner J, Müller P, Herzig P, Roller A, Belousov A, et al. Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors. Cancer Immunol Res. 2015;3:1344-55 pubmed publisher
Guerau de Arellano M, Smith K, Godlewski J, Liu Y, Winger R, Lawler S, et al. Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain. 2011;134:3578-89 pubmed publisher
Alanio C, Lemaitre F, Law H, Hasan M, Albert M. Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. Blood. 2010;115:3718-25 pubmed publisher
Iannello A, Boulassel M, Samarani S, Debbeche O, Tremblay C, Toma E, et al. Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. J Immunol. 2010;184:114-26 pubmed publisher
Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee H, Steinle A. NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009;113:358-69 pubmed publisher
Palendira U, Chinn R, Raza W, Piper K, Pratt G, Machado L, et al. Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood. 2008;112:3293-302 pubmed publisher
Thakral D, Dobbins J, Devine L, Kavathas P. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008;180:7431-42 pubmed
Roque S, Nobrega C, Appelberg R, Correia Neves M. IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol. 2007;178:8028-35 pubmed
Smeltz R. Profound enhancement of the IL-12/IL-18 pathway of IFN-gamma secretion in human CD8+ memory T cell subsets via IL-15. J Immunol. 2007;178:4786-92 pubmed
product information
Antigen :
CD45RA
Apps. Abbrev. :
Flow Cytometry, IHC-P
Cat # :
304130
Clone :
HI100
Item :
Brilliant Violet 421™ anti-human CD45RA
Isotype :
Mouse IgG2b, κ
Other Names :
GP180, L-CA, LCA, LY5, T200, PTPRC
Size :
100 tests
Price (USD) :
345 USD
Reactivity :
Human, Cross-Reactivity: Chimpanzee
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV421
Application Notes :
Additional reported applications (for relevant formats of this clone) include: inhibition of CD45 functions 2 , immunohistochemical staining of frozen tissue sections 3 and formalin-fixed paraffin-embedded tissue sections 4 , and immunocytochemistry 15,16 .
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA