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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD45
catalog :
304037
quantity :
500 tests
price :
336 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
HI30
reactivity :
human
application :
flow cytometry
more info or order :
citations: 54
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
Buenafe A, Dorrell C, Reddy A, Klimek J, Marks D. Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids. Sci Rep. 2022;12:3556 pubmed publisher
Vanuytsel K, Villacorta Martin C, Lindstrom Vautrin J, Wang Z, Garcia Beltran W, Vrbanac V, et al. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022;13:1103 pubmed publisher
Ruan Y, Kim H, Ogana H, Gang E, Li S, Liu H, et al. In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia. Exp Ther Med. 2022;23:47 pubmed publisher
Cortesi E, Meeusen B, Vanstapel A, Verleden S, Vanaudenaerde B, Wuyts W, et al. Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases. Cells. 2021;10: pubmed publisher
Karim F, Gazy I, Cele S, Zungu Y, Krause R, Bernstein M, et al. HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave. elife. 2021;10: pubmed publisher
Park J, Santich B, Xu H, Lum L, Cheung N. Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release. J Immunother Cancer. 2021;9: pubmed publisher
Hormaechea Agulla D, Matatall K, Le D, Kain B, Long X, Kus P, et al. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling. Cell Stem Cell. 2021;28:1428-1442.e6 pubmed publisher
de Jonge K, Tillé L, Lourenço J, Maby El Hajjami H, Nassiri S, Racle J, et al. Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients. Oncoimmunology. 2021;10:1873585 pubmed publisher
Chen I. Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts. Bio Protoc. 2020;10:e3854 pubmed publisher
Park J, Cheung N. GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma. J Hematol Oncol. 2020;13:172 pubmed publisher
Luzuriaga J, Irurzun J, Irastorza I, Unda F, Ibarretxe G, Pineda J. Vasculogenesis from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media. Biomedicines. 2020;8: pubmed publisher
Hu X, Liu Y, Zhang X, Kong D, Kong J, Zhao D, et al. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer. Neoplasia. 2020;22:539-553 pubmed publisher
Schmiderer L, Subramaniam A, Žemaitis K, Bäckström A, Yudovich D, Soboleva S, et al. Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws. Proc Natl Acad Sci U S A. 2020;117:21267-21273 pubmed publisher
Jiang G, Shi L, Zheng X, Zhang X, Wu K, Liu B, et al. Androgen receptor affects the response to immune checkpoint therapy by suppressing PD-L1 in hepatocellular carcinoma. Aging (Albany NY). 2020;12:11466-11484 pubmed publisher
Hong Y, He H, Jiang G, Zhang H, Tao W, Ding Y, et al. miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. Aging Cell. 2020;19:e13128 pubmed publisher
Łyszkiewicz M, Zietara N, Frey L, Pannicke U, Stern M, Liu Y, et al. Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells. Nat Commun. 2020;11:1031 pubmed publisher
Vignard V, Labbé M, Marec N, André Grégoire G, Jouand N, Fonteneau J, et al. MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma. Cancer Immunol Res. 2020;8:255-267 pubmed publisher
Huang X, Zhang H, Liang X, Hong Y, Mao M, Han Q, et al. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena. Oxid Med Cell Longev. 2019;2019:1305049 pubmed publisher
Zhang Y, Zhu W, He H, Fan B, Deng R, Hong Y, et al. Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. Aging (Albany NY). 2019;11:12641-12660 pubmed publisher
de Andrade L, Lu Y, Luoma A, Ito Y, Pan D, Pyrdol J, et al. Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight. 2019;4: pubmed publisher
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, et al. Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors. Cell Rep. 2019;29:2307-2320.e6 pubmed publisher
Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, et al. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica. 2019;: pubmed publisher
Yang M, Guo Q, Peng H, Xiao Y, Xiao Y, Huang Y, et al. Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome. J Exp Med. 2019;: pubmed publisher
Dangaj D, Bruand M, Grimm A, Ronet C, Barras D, Duttagupta P, et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. 2019;35:885-900.e10 pubmed publisher
Salvany Celades M, van der Zwan A, Benner M, Setrajcic Dragos V, Bougleux Gomes H, Iyer V, et al. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Rep. 2019;27:2537-2547.e5 pubmed publisher
He H, Yu B, Liu Z, Ye G, You W, Hong Y, et al. Vascular progenitor cell senescence in patients with Marfan syndrome. J Cell Mol Med. 2019;23:4139-4152 pubmed publisher
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher
Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, et al. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses. Immunity. 2019;50:738-750.e7 pubmed publisher
Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka M, King S, et al. Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans. Front Immunol. 2018;9:2857 pubmed publisher
Li C, Xiao Y, Yang M, Su T, Sun X, Guo Q, et al. Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. J Clin Invest. 2018;128:5251-5266 pubmed publisher
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, et al. Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages. Cell. 2018;175:442-457.e23 pubmed publisher
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher
Murakami T, Kim J, Li Y, Green G, Shikanov A, Ono A. Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nat Commun. 2018;9:2436 pubmed publisher
Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang C, et al. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models. Nat Commun. 2018;9:1915 pubmed publisher
Guzzi N, Ciesla M, Ngoc P, Lang S, Arora S, Dimitriou M, et al. Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Cell. 2018;173:1204-1216.e26 pubmed publisher
Kasagi Y, Chandramouleeswaran P, Whelan K, Tanaka K, Giroux V, Sharma M, et al. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol. 2018;5:333-352 pubmed publisher
Yamauchi T, Masuda T, Canver M, Seiler M, Semba Y, Shboul M, et al. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. 2018;33:386-400.e5 pubmed publisher
Palazzo A, Herter S, Grosmaire L, Jones R, Frey C, Limani F, et al. The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo. J Immunol. 2018;200:2304-2312 pubmed publisher
Racle J, de Jonge K, Baumgaertner P, Speiser D, Gfeller D. Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data. elife. 2017;6: pubmed publisher
Sun Y, Guo W, Xu Y, Shi Y, Gong Z, Ji Y, et al. Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma. Clin Cancer Res. 2018;24:547-559 pubmed publisher
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
Park E, Duffy S, Ma H. Microfluidic Separation of Circulating Tumor Cells Based on Size and Deformability. Methods Mol Biol. 2017;1634:21-32 pubmed publisher
Herold N, Rudd S, Ljungblad L, Sanjiv K, Myrberg I, Paulin C, et al. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med. 2017;23:256-263 pubmed publisher
O Dea K, Porter J, Tirlapur N, Katbeh U, Singh S, Handy J, et al. Circulating Microvesicles Are Elevated Acutely following Major Burns Injury and Associated with Clinical Severity. PLoS ONE. 2016;11:e0167801 pubmed publisher
Petit N, Lambert Niclot S, Marcelin A, Garcia S, Marodon G. HIV Replication Is Not Controlled by CD8+ T Cells during the Acute Phase of the Infection in Humanized Mice. PLoS ONE. 2015;10:e0138420 pubmed publisher
Lee J, Breton G, Oliveira T, Zhou Y, Aljoufi A, PUHR S, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212:385-99 pubmed publisher
Breton G, Lee J, Zhou Y, Schreiber J, Keler T, PUHR S, et al. Circulating precursors of human CD1c+ and CD141+ dendritic cells. J Exp Med. 2015;212:401-13 pubmed publisher
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose John S, Moldenhauer G, et al. Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Cancer Res. 2014;74:3429-40 pubmed publisher
Turetsky A, Kim E, Kohler R, Miller M, Weissleder R. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014;4:4782 pubmed publisher
Gleason M, Ross J, Warlick E, Lund T, Verneris M, Wiernik A, et al. CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets. Blood. 2014;123:3016-26 pubmed publisher
Bushway M, Gerber S, Fenton B, Miller R, Lord E, Murphy S. Morphological and phenotypic analyses of the human placenta using whole mount immunofluorescence. Biol Reprod. 2014;90:110 pubmed publisher
Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, et al. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood. 2007;110:151-60 pubmed
product information
Antigen :
CD45
Apps. Abbrev. :
Flow Cytometry
Cat # :
304037
Clone :
HI30
Item :
APC anti-human CD45
Isotype :
Mouse IgG1, κ
Other Names :
LCA, T200
Size :
500 tests
Price (USD) :
336 USD
Reactivity :
Human, Cross-Reactivity: Chimpanzee
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections 9 , inhibition of CD45 functions 4 , immunofluorescence 11 , Western blotting 3 , and spatial biology (IBEX) 16,17 . It was found that the HI30 clone and the 2D1 clone can cross block each other s binding.
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA