product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD45
catalog :
304012
quantity :
100 tests
price :
105 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
HI30
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 92
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 2a
Eikmans M, van der Keur C, Anholts J, Drabbels J, van Beelen E, de Sousa Lopes S, et al. Primary Trophoblast Cultures: Characterization of HLA Profiles and Immune Cell Interactions. Front Immunol. 2022;13:814019 pubmed publisher
  • flow cytometry; human; loading ...; fig s7c
Dmitrieva N, Walts A, Nguyen D, Grubb A, Zhang X, Wang X, et al. Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome. J Clin Invest. 2020;130:4167-4181 pubmed publisher
  • flow cytometry; human; loading ...; fig 2e
Dangaj D, Bruand M, Grimm A, Ronet C, Barras D, Duttagupta P, et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. 2019;35:885-900.e10 pubmed publisher
  • flow cytometry; human; loading ...; fig s7a
Crippa S, Rossella V, Aprile A, Silvestri L, Rivis S, Scaramuzza S, et al. Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity. J Clin Invest. 2019;129:1566-1580 pubmed publisher
  • flow cytometry; human; loading ...; fig s16b
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher
  • flow cytometry; human; loading ...; fig 1c
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
  • flow cytometry; mouse; fig 5
Fisher J, Flutter B, Wesemann F, Frosch J, Rossig C, Gustafsson K, et al. Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells. Oncoimmunology. 2016;5:e1025194 pubmed
  • flow cytometry; human; fig 1
Li C, Cheng P, Liang M, Chen Y, Lu Q, Wang J, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest. 2015;125:1509-22 pubmed publisher
  • flow cytometry; human
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
Xiao Y, Cai G, Feng X, Li Y, Guo W, Guo Q, et al. Splicing factor YBX1 regulates bone marrow stromal cell fate during aging. EMBO J. 2023;42:e111762 pubmed publisher
Sun J, Zhang H, Wei W, Xiao X, Huang C, Wang L, et al. Regulation of CD8+ T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer. Oncogene. 2023;42:1247-1262 pubmed publisher
Li M, Budai M, Chen M, Wang J. Targeting HIV-1 reservoirs in T cell subsets. Front Immunol. 2023;14:1087923 pubmed publisher
G xf3 mez Gallegos A, Ram xed rez Vidal L, Becerril Rico J, P xe9 rez Islas E, Hernandez Peralta Z, Toledo Guzm xe1 n M, et al. CD24+CD44+CD54+EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence. Stem Cell Res Ther. 2023;14:16 pubmed publisher
Xu Q, Muyayalo K, Zhang Y, Wang H, Lin X, Liao A. Altered vitamin D metabolism is involved in the dysregulation of γδT cell function and their crosstalk with trophoblasts in recurrent pregnancy loss. Am J Reprod Immunol. 2023;89:e13581 pubmed publisher
Siepe D, Henneberg L, Wilson S, Hess G, Bassik M, Zinn K, et al. Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform. elife. 2022;11: pubmed publisher
Klawitter M, El Ayoubi A, Buch J, R xfc ttinger J, Ehrenfeld M, Lichtenegger E, et al. The Oncolytic Adenovirus XVir-N-31, in Combination with the Blockade of the PD-1/PD-L1 Axis, Conveys Abscopal Effects in a Humanized Glioblastoma Mouse Model. Int J Mol Sci. 2022;23: pubmed publisher
Lee M, Geitgey D, Hamilton J, Boss J, Scharer C, Spangle J, et al. Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Front Cell Dev Biol. 2022;10:909557 pubmed publisher
Xiao Q, Zhang X, Tu L, Cao J, Hinrichs C, Su X. Size-dependent activation of CAR-T cells. Sci Immunol. 2022;7:eabl3995 pubmed publisher
Michalek S, Goj T, Plazzo A, Marovca B, Bornhauser B, Brunner T. LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. EMBO Rep. 2022;23:e54195 pubmed publisher
Delgado Gonzalez A, Huang Y, Porpiglia E, Donoso K, Gonzalez V, Fantl W. Measuring trogocytosis between ovarian tumor and natural killer cells. STAR Protoc. 2022;3:101425 pubmed publisher
Bashyal N, Lee T, Chang D, Jung J, Kim M, Acharya R, et al. Improving the Safety of Mesenchymal Stem Cell-Based Ex Vivo Therapy Using Herpes Simplex Virus Thymidine Kinase. Mol Cells. 2022;45:479-494 pubmed publisher
Patel C, Shi L, Whitesides J, Foster B, Fajardo R, Quillen E, et al. A New Method of Bone Stromal Cell Characterization by Flow Cytometry. Curr Protoc. 2022;2:e400 pubmed publisher
Buenafe A, Dorrell C, Reddy A, Klimek J, Marks D. Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids. Sci Rep. 2022;12:3556 pubmed publisher
Vanuytsel K, Villacorta Martin C, Lindstrom Vautrin J, Wang Z, Garcia Beltran W, Vrbanac V, et al. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022;13:1103 pubmed publisher
Ruan Y, Kim H, Ogana H, Gang E, Li S, Liu H, et al. In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia. Exp Ther Med. 2022;23:47 pubmed publisher
Cortesi E, Meeusen B, Vanstapel A, Verleden S, Vanaudenaerde B, Wuyts W, et al. Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases. Cells. 2021;10: pubmed publisher
Karim F, Gazy I, Cele S, Zungu Y, Krause R, Bernstein M, et al. HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave. elife. 2021;10: pubmed publisher
Park J, Wang L, Cheung N. Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response. J Hematol Oncol. 2021;14:142 pubmed publisher
Gonzalez V, Huang Y, Delgado Gonzalez A, Chen S, Donoso K, Sachs K, et al. High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment. Cell Rep. 2021;36:109632 pubmed publisher
Subedi A, Liu Q, Ayyathan D, Sharon D, Cathelin S, Hosseini M, et al. Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis. Cell Stem Cell. 2021;28:1851-1867.e8 pubmed publisher
Niu L, Wang Y, Wong C, Gao S, Mo X, Huang X. Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage. Transl Oncol. 2021;14:101159 pubmed publisher
Sun Y, Wu L, Liu S, Jiang M, Hu B, Zhou K, et al. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma. Nat Commun. 2021;12:4091 pubmed publisher
Loreth D, Schuette M, Zinke J, Mohme M, Piffko A, Schneegans S, et al. CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis. Int J Mol Sci. 2021;22: pubmed publisher
Saygin C, Hu E, Zhang P, Sher S, Lozanski A, Doong T, et al. Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq. Leukemia. 2021;35:3406-3420 pubmed publisher
Park J, Santich B, Xu H, Lum L, Cheung N. Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release. J Immunother Cancer. 2021;9: pubmed publisher
Hormaechea Agulla D, Matatall K, Le D, Kain B, Long X, Kus P, et al. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling. Cell Stem Cell. 2021;28:1428-1442.e6 pubmed publisher
Chen I. Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts. Bio Protoc. 2020;10:e3854 pubmed publisher
Paul S, Pearlman A, Douglass J, Mog B, Hsiue E, Hwang M, et al. TCR β chain-directed bispecific antibodies for the treatment of T cell cancers. Sci Transl Med. 2021;13: pubmed publisher
de Jonge K, Tillé L, Lourenço J, Maby El Hajjami H, Nassiri S, Racle J, et al. Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients. Oncoimmunology. 2021;10:1873585 pubmed publisher
Shi L, Han Q, Hong Y, Li W, Gong G, Cui J, et al. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis. Stem Cell Res Ther. 2021;12:147 pubmed publisher
Wi xdf feld J, Nozaki I, Mathews M, Raschka T, Ebeling C, Hornung V, et al. Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype. Glia. 2021;69:1393-1412 pubmed publisher
Alhaj Hussen K, Michonneau D, Biajoux V, Keita S, Dubouchet L, Nelson E, et al. CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease. Front Immunol. 2020;11:579776 pubmed publisher
Park J, Cheung N. GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma. J Hematol Oncol. 2020;13:172 pubmed publisher
Luzuriaga J, Irurzun J, Irastorza I, Unda F, Ibarretxe G, Pineda J. Vasculogenesis from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media. Biomedicines. 2020;8: pubmed publisher
Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, et al. Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020;11:5327 pubmed publisher
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, et al. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020;22:1295-1306 pubmed publisher
Hu X, Liu Y, Zhang X, Kong D, Kong J, Zhao D, et al. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer. Neoplasia. 2020;22:539-553 pubmed publisher
Hultmark S, Baudet A, Schmiderer L, Prabhala P, Palma Tortosa S, Sandén C, et al. Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells. Haematologica. 2021;106:2566-2577 pubmed publisher
Schmiderer L, Subramaniam A, Žemaitis K, Bäckström A, Yudovich D, Soboleva S, et al. Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws. Proc Natl Acad Sci U S A. 2020;117:21267-21273 pubmed publisher
Li M, Liu W, Bauch T, Graviss E, Arduino R, Kimata J, et al. Clearance of HIV infection by selective elimination of host cells capable of producing HIV. Nat Commun. 2020;11:4051 pubmed publisher
Dong R, Libby K, Blaeschke F, Fuchs W, Marson A, Vale R, et al. Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR). EMBO J. 2020;39:e104730 pubmed publisher
Jiang G, Shi L, Zheng X, Zhang X, Wu K, Liu B, et al. Androgen receptor affects the response to immune checkpoint therapy by suppressing PD-L1 in hepatocellular carcinoma. Aging (Albany NY). 2020;12:11466-11484 pubmed publisher
Sugimura R, Ohta R, Mori C, Li A, Mano T, Sano E, et al. Biomimetic aorta-gonad-Mesonephros-on-a-Chip to study human developmental hematopoiesis. Biomed Microdevices. 2020;22:34 pubmed publisher
Kobayashi Y, Yamada D, Kawai T, Sato Y, Teshima T, Yamada Y, et al. Different immunological effects of the molecular targeted agents sunitinib, everolimus and temsirolimus in patients with renal cell carcinoma. Int J Oncol. 2020;56:999-1013 pubmed publisher
Shao S, Koh M, Schultz P. Expanding the genetic code of the human hematopoietic system. Proc Natl Acad Sci U S A. 2020;117:8845-8849 pubmed publisher
Weitz J, Jacques Silva C, Qadir M, Umland O, Pereira E, Qureshi F, et al. Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling. Diabetes. 2020;69:1206-1218 pubmed publisher
Hong Y, He H, Jiang G, Zhang H, Tao W, Ding Y, et al. miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. Aging Cell. 2020;19:e13128 pubmed publisher
Łyszkiewicz M, Zietara N, Frey L, Pannicke U, Stern M, Liu Y, et al. Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells. Nat Commun. 2020;11:1031 pubmed publisher
Huang X, Zhang H, Liang X, Hong Y, Mao M, Han Q, et al. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena. Oxid Med Cell Longev. 2019;2019:1305049 pubmed publisher
Zhang Y, Zhu W, He H, Fan B, Deng R, Hong Y, et al. Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. Aging (Albany NY). 2019;11:12641-12660 pubmed publisher
Vignard V, Labbé M, Marec N, André Grégoire G, Jouand N, Fonteneau J, et al. MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma. Cancer Immunol Res. 2020;8:255-267 pubmed publisher
de Andrade L, Lu Y, Luoma A, Ito Y, Pan D, Pyrdol J, et al. Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight. 2019;4: pubmed publisher
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, et al. Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors. Cell Rep. 2019;29:2307-2320.e6 pubmed publisher
Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, et al. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica. 2019;: pubmed publisher
Yang M, Guo Q, Peng H, Xiao Y, Xiao Y, Huang Y, et al. Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome. J Exp Med. 2019;: pubmed publisher
Salvany Celades M, van der Zwan A, Benner M, Setrajcic Dragos V, Bougleux Gomes H, Iyer V, et al. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Rep. 2019;27:2537-2547.e5 pubmed publisher
He H, Yu B, Liu Z, Ye G, You W, Hong Y, et al. Vascular progenitor cell senescence in patients with Marfan syndrome. J Cell Mol Med. 2019;23:4139-4152 pubmed publisher
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher
Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, et al. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses. Immunity. 2019;50:738-750.e7 pubmed publisher
Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka M, King S, et al. Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans. Front Immunol. 2018;9:2857 pubmed publisher
Li C, Xiao Y, Yang M, Su T, Sun X, Guo Q, et al. Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. J Clin Invest. 2018;128:5251-5266 pubmed publisher
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, et al. Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages. Cell. 2018;175:442-457.e23 pubmed publisher
Murakami T, Kim J, Li Y, Green G, Shikanov A, Ono A. Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nat Commun. 2018;9:2436 pubmed publisher
Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang C, et al. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models. Nat Commun. 2018;9:1915 pubmed publisher
Guzzi N, Ciesla M, Ngoc P, Lang S, Arora S, Dimitriou M, et al. Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Cell. 2018;173:1204-1216.e26 pubmed publisher
Kasagi Y, Chandramouleeswaran P, Whelan K, Tanaka K, Giroux V, Sharma M, et al. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol. 2018;5:333-352 pubmed publisher
Yamauchi T, Masuda T, Canver M, Seiler M, Semba Y, Shboul M, et al. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. 2018;33:386-400.e5 pubmed publisher
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Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose John S, Moldenhauer G, et al. Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Cancer Res. 2014;74:3429-40 pubmed publisher
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product information
Antigen :
CD45
Apps. Abbrev. :
FC
Cat # :
304012
Clone :
HI30
Item :
APC anti-human CD45
Isotype :
Mouse IgG1, κ
Other Names :
LCA, T200
Size :
100 tests
Price (USD) :
105 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections^9, inhibition of CD45 functions^4, immunofluorescence^11, Western blotting^3, and spatial biology (IBEX)^16,17.It was found that the HI30 clone and the 2D1 clone can cross block each other's binding.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA