product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human CD45
catalog :
304007
quantity :
25 tests
price :
28 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
HI30
reactivity :
human
application :
flow cytometry
more info or order :
citations: 84
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Zong D, Huang B, LI Y, Lu Y, Xiang N, Guo C, et al. Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis. BMC Biol. 2021;19:79 pubmed publisher
  • flow cytometry; human; 1:33; loading ...; fig 3a
Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature. 2017;541:541-545 pubmed publisher
  • flow cytometry; human; loading ...; fig 3d
Ye C, Wang W, Cheng L, Li G, Wen M, Wang Q, et al. Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice. J Virol. 2017;91: pubmed publisher
  • flow cytometry; human; 1:25; loading ...
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
  • flow cytometry; human
Sumitomo S, Fujio K, Okamura T, Morita K, Ishigaki K, Suzukawa K, et al. Transcription factor early growth response 3 is associated with the TGF-?1 expression and the regulatory activity of CD4-positive T cells in vivo. J Immunol. 2013;191:2351-9 pubmed publisher
  • flow cytometry; human
Bendall S, Simonds E, Qiu P, Amir E, Krutzik P, Finck R, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-96 pubmed publisher
Feng X, Wang L, Zhou R, Zhou R, Chen L, Peng H, et al. Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging. Nat Commun. 2023;14:3208 pubmed publisher
Hu X, White K, Olroyd A, Dejesus R, Dominguez A, Dowdle W, et al. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nat Biotechnol. 2023;: pubmed publisher
Liu Y, Chen Y, Li X, Cao C, Zhang H, Zhou C, et al. Dissection of Cellular Communication between Human Primary Osteoblasts and Bone Marrow Mesenchymal Stem Cells in Osteoarthritis at Single-Cell Resolution. Int J Stem Cells. 2023;16:342-355 pubmed publisher
Hu X, Manner K, Dejesus R, White K, Gattis C, Ngo P, et al. Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. Nat Commun. 2023;14:2020 pubmed publisher
Palam L, Ramdas B, Pickerell K, Pasupuleti S, Kanumuri R, Cesarano A, et al. Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway. JCI Insight. 2023;8: pubmed publisher
Jenkins E, K xf6 rbel M, O Brien Ball C, McColl J, Chen K, Kotowski M, et al. Antigen discrimination by T cells relies on size-constrained microvillar contact. Nat Commun. 2023;14:1611 pubmed publisher
Wang J, Dallmann R, Lu R, Yan J, Charmet J. Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology. ACS Sens. 2023;8:1200-1210 pubmed publisher
Ferreira Baptista C, Queir xf3 s A, Ferreira R, Fernandes M, Cola xe7 o B, Gomes P. The Osteogenic Potential of Falciform Ligament-Derived Stromal Cells-A Comparative Analysis between Two Osteogenic Induction Programs. Bioengineering (Basel). 2022;9: pubmed publisher
Robb K, Audet J, Gandhi R, Viswanathan S. Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic "fitness" ranges in response to culture process parameters. Front Immunol. 2022;13:972095 pubmed publisher
Mart xed nez Sabadell A, Ovejero Romero P, Arribas J, Arenas E. Protocol to generate a patient derived xenograft model of acquired resistance to immunotherapy in humanized mice. STAR Protoc. 2022;3:101712 pubmed publisher
Zhang J, Qu X, Li J, Harada A, Hua Y, Yoshida N, et al. Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing. Int J Mol Sci. 2022;23: pubmed publisher
Hopke A, Lin T, Scherer A, Shay A, Timmer K, Wilson Mifsud B, et al. Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi. iScience. 2022;25:105226 pubmed publisher
Mart xed nez Sabadell A, Morancho B, Rius Ruiz I, Rom xe1 n Alonso M, Ovejero Romero P, Escorihuela M, et al. The target antigen determines the mechanism of acquired resistance to T cell-based therapies. Cell Rep. 2022;41:111430 pubmed publisher
Silva A, Rodrigues C, Ferreira I, Santos L, Santos D, Ara xfa jo T, et al. A Novel Detection Method of Breast Cancer through a Simple Panel of Biomarkers. Int J Mol Sci. 2022;23: pubmed publisher
Wang W, Yan M, Aarabi G, Peters U, Freytag M, Gosau M, et al. Cultivation of Cryopreserved Human Dental Pulp Stem Cells-A New Approach to Maintaining Dental Pulp Tissue. Int J Mol Sci. 2022;23: pubmed publisher
Y xfc ce M, Albayrak E. Hyperthermia-stimulated tonsil-mesenchymal stromal cells suppress hematological cancer cells through downregulation of IL-6. J Cell Biochem. 2022;123:1966-1979 pubmed publisher
Polisetti N, Sharaf L, Reinhard T, Schlunck G. Isolation and ex vivo Expansion of Limbal Mesenchymal Stromal Cells. Bio Protoc. 2022;12: pubmed publisher
Cai S, Fan C, Xie L, Zhong H, Li A, Lv S, et al. Single-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells. Cell Biosci. 2022;12:115 pubmed publisher
Gao G, Wang L, Li C. Circ_0006790 carried by bone marrow mesenchymal stem cell-derived exosomes regulates S100A11 DNA methylation through binding to CBX7 in pancreatic ductal adenocarcinoma. Am J Cancer Res. 2022;12:1934-1959 pubmed
Omer Javed A, Pedrazzani G, Albano L, Ghaus S, Latroche C, Manzi M, et al. Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells. Cell. 2022;185:2248-2264.e21 pubmed publisher
Aubrey B, Cutler J, Bourgeois W, Donovan K, Gu S, Hatton C, et al. IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nat Cancer. 2022;3:595-613 pubmed publisher
Zhang B, Xiao M, Cheng X, Bai Y, Chen H, Yu Q, et al. Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways. Stem Cells Int. 2022;2022:2236250 pubmed publisher
Leick M, Silva H, Scarf xf2 I, Larson R, Choi B, Bouffard A, et al. Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia. Cancer Cell. 2022;40:494-508.e5 pubmed publisher
Wu J, Feng Z, Chen L, Li Y, Bian H, Geng J, et al. TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models. Nat Commun. 2022;13:676 pubmed publisher
Kerdidani D, Aerakis E, Verrou K, Angelidis I, Douka K, Maniou M, et al. Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. J Exp Med. 2022;219: pubmed publisher
Zhou T, He C, Lai P, Yang Z, Liu Y, Xu H, et al. miR-204-containing exosomes ameliorate GVHD-associated dry eye disease. Sci Adv. 2022;8:eabj9617 pubmed publisher
Daskou M, Mu W, Sharma M, Vasilopoulos H, Heymans R, Ritou E, et al. ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV. PLoS Pathog. 2022;18:e1010160 pubmed publisher
Alisjahbana A, Gao Y, Sleiers N, Evren E, Brownlie D, von Kries A, et al. CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung. Front Immunol. 2021;12:752104 pubmed publisher
Witkowski M, Tizian C, Ferreira Gomes M, Niemeyer D, Jones T, Heinrich F, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021;600:295-301 pubmed publisher
Binnewies M, Pollack J, Rudolph J, Dash S, Abushawish M, Lee T, et al. Targeting TREM2 on tumor-associated macrophages enhances immunotherapy. Cell Rep. 2021;37:109844 pubmed publisher
Schwabenland M, Bruck W, Priller J, Stadelmann C, Lassmann H, Prinz M. Analyzing microglial phenotypes across neuropathologies: a practical guide. Acta Neuropathol. 2021;142:923-936 pubmed publisher
Fei D, Xia Y, Zhai Q, Wang Y, Zhou F, Zhao W, et al. Exosomes Regulate Interclonal Communication on Osteogenic Differentiation Among Heterogeneous Osteogenic Single-Cell Clones Through PINK1/Parkin-Mediated Mitophagy. Front Cell Dev Biol. 2021;9:687258 pubmed publisher
Burger M, Cruz A, Crossland G, Gaglia G, Ritch C, Blatt S, et al. Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Cell. 2021;184:4996-5014.e26 pubmed publisher
Woan K, Kim H, Bjordahl R, Davis Z, Gaidarova S, Goulding J, et al. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell. 2021;28:2062-2075.e5 pubmed publisher
Alcántara Hernández M, Idoyaga J. Mass cytometry profiling of human dendritic cells in blood and tissues. Nat Protoc. 2021;16:4855-4877 pubmed publisher
Labedz Maslowska A, Szkaradek A, Mierzwinski T, Madeja Z, Zuba Surma E. Processing and Ex Vivo Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells for the Development of an Advanced Therapy Medicinal Product for use in Humans. Cells. 2021;10: pubmed publisher
Gong Y, Yang J, Li X, Zhou C, Chen Y, Wang Z, et al. A systematic dissection of human primary osteoblasts in vivo at single-cell resolution. Aging (Albany NY). 2021;13:20629-20650 pubmed publisher
Wang M, Yan Y, Zhang Z, Yao X, Duan X, Jiang Z, et al. Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes. iScience. 2021;24:102766 pubmed publisher
Hagel J, Bennett K, Buffa F, Klenerman P, Willberg C, Powell K. Defining T Cell Subsets in Human Tonsils Using ChipCytometry. J Immunol. 2021;206:3073-3082 pubmed publisher
Zheng C, Sui B, Zhang X, Hu J, Chen J, Liu J, et al. Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles. 2021;10:e12109 pubmed publisher
Hu Q, Hong Y, Qi P, Lu G, Mai X, Xu S, et al. Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling. Nat Commun. 2021;12:2186 pubmed publisher
Zhang Q, Xiang E, Rao W, Zhang Y, Xiao C, Li C, et al. Intra-articular injection of human umbilical cord mesenchymal stem cells ameliorates monosodium iodoacetate-induced osteoarthritis in rats by inhibiting cartilage degradation and inflammation. Bone Joint Res. 2021;10:226-236 pubmed publisher
Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed publisher
Tu C, Du Z, Zhang H, Feng Y, Qi Y, Zheng Y, et al. Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells. Theranostics. 2021;11:2364-2380 pubmed publisher
Costa M, Serra J, McDevitt T, Cabral J, da Silva C, Ferreira F. Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids. Biotechnol J. 2021;16:e2000389 pubmed publisher
Evren E, Ringqvist E, Tripathi K, Sleiers N, Rives I, Alisjahbana A, et al. Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity. 2021;54:259-275.e7 pubmed publisher
Gumber D, Do M, Suresh Kumar N, Sonavane P, Wu C, Cruz L, et al. Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells. elife. 2020;9: pubmed publisher
Morton J, Alzofon N, Keysar S, Chimed T, Reisinger J, Perrenoud L, et al. Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft. Mol Cancer Res. 2021;19:346-357 pubmed publisher
Sperber H, Togarrati P, Raymond K, Bouzidi M, Gilfanova R, Gutierrez A, et al. μ-Lat: A mouse model to evaluate human immunodeficiency virus eradication strategies. FASEB J. 2020;34:14615-14630 pubmed publisher
Evans R, Antonelou M, Sathiananthamoorthy S, Rega M, Henderson S, Ceron Gutierrez L, et al. Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses. Nat Commun. 2020;11:4368 pubmed publisher
Melzer C, Jacobs R, Dittmar T, Pich A, von der Ohe J, Yang Y, et al. Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line. Int J Mol Sci. 2020;21: pubmed publisher
Thompson E, Bates L, Ibrahim I, Sewpaul A, Stenberg B, McNeill A, et al. Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation. Am J Transplant. 2021;21:1402-1414 pubmed publisher
Uslu M, Albayrak E, Kocaba x15f F. Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment. J Cell Physiol. 2020;235:9644-9666 pubmed publisher
Vincent V, Thakkar H, Verma A, Sen A, Chandran N, Singh A. A novel flow cytometry-based quantitative monocyte adhesion assay to estimate endothelial cell activation in vitro. Biotechniques. 2020;68:325-333 pubmed publisher
Singh A, Denu R, Wolfe S, Sperger J, Schehr J, Witkowsky T, et al. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol Oncol. 2020;: pubmed publisher
Lu Y, Zhao Q, Liao J, Song E, Xia Q, Pan J, et al. Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity. Cell. 2020;180:1081-1097.e24 pubmed publisher
Helmink B, Reddy S, Gao J, Zhang S, Basar R, Thakur R, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020;577:549-555 pubmed publisher
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, et al. Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors. Cell Rep. 2019;29:2307-2320.e6 pubmed publisher
Wang D, Hu X, Liu C, Jia Y, Bai Y, Cai C, et al. Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers. Cell Res. 2019;29:832-845 pubmed publisher
Tomellini E, Fares I, Lehnertz B, Chagraoui J, Mayotte N, Macrae T, et al. Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells. Cell Rep. 2019;28:1063-1073.e5 pubmed publisher
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella J, Corneau S, et al. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia. Cancer Cell. 2019;36:84-99.e8 pubmed publisher
Tancharoen W, Aungsuchawan S, Pothacharoen P, Bumroongkit K, Puaninta C, Pangjaidee N, et al. Human platelet lysate as an alternative to fetal bovine serum for culture and endothelial differentiation of human amniotic fluid mesenchymal stem cells. Mol Med Rep. 2019;19:5123-5132 pubmed publisher
Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin A, Brinkert K, et al. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections. Nat Commun. 2018;9:5088 pubmed publisher
Sade Feldman M, Yizhak K, Bjorgaard S, Ray J, de Boer C, Jenkins R, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175:998-1013.e20 pubmed publisher
Hsu J, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, et al. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018;23:700-713.e6 pubmed publisher
Yuan J, Ma Y, Huang T, Chen Y, Peng Y, Li B, et al. Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. Mol Cell. 2018;72:380-394.e7 pubmed publisher
Morton J, Keysar S, Perrenoud L, Chimed T, Reisinger J, Jackson B, et al. Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer. Mol Carcinog. 2018;57:1651-1663 pubmed publisher
Guzzi N, Ciesla M, Ngoc P, Lang S, Arora S, Dimitriou M, et al. Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Cell. 2018;173:1204-1216.e26 pubmed publisher
Lee H, Kim Y, Sim C, Heo S, Song I, Park H, et al. Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer. Oncotarget. 2017;8:113345-113359 pubmed publisher
Yamada E, Nakaoka S, Klein L, Reith E, Langer S, Hopfensperger K, et al. Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host Microbe. 2018;23:110-120.e7 pubmed publisher
Nakano Y, Misawa N, Juarez Fernandez G, Moriwaki M, Nakaoka S, Funo T, et al. HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation. PLoS Pathog. 2017;13:e1006348 pubmed publisher
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Lee J, Breton G, Oliveira T, Zhou Y, Aljoufi A, PUHR S, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212:385-99 pubmed publisher
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product information
Antigen :
CD45
Apps. Abbrev. :
FC
Cat # :
304007
Clone :
HI30
Item :
PE anti-human CD45
Isotype :
Mouse IgG1, κ
Other Names :
LCA, T200
Size :
25 tests
Price (USD) :
28 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and formalin-fixed paraffin-embedded tissue sections^9, inhibition of CD45 functions^4, immunofluorescence^11, Western blotting^3, and spatial biology (IBEX)^16,17.It was found that the HI30 clone and the 2D1 clone can cross block each other's binding.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA