Ultra-LEAF™ Purified anti-human CD11b (activated) | BioLegend 301425 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Ultra-LEAF™ Purified anti-human CD11b (activated)

catalog :

301425

quantity :

100 μg

price :

270 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CBRM1/5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-23934 L, sc-23934
Invitrogen: 16-0113-025, 16-0113-050, 63-0113-42, 17-0113-42, 17-0113-41, 46-0113-42, 16-0113-38, 25-0113-42, 11-0113-42, 12-0113-42, 14-0113-81, 62-0113-41, 62-0113-42, 16-0113-82, 25-0113-41, 56-0113-42
Exbio: 12-172-C100, 1P-172-T025, 1P-172-T100, 11-172-C025, 11-172-C100
OriGene: TA320385

reactivity :

human

application :

neutralization, immunoprecipitation, flow cytometry

citations: 1

Reference
Reed J, Preston Hurlburt P, Philbrick W, Betancur G, Korah M, LUCAS C, et al. The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling. PLoS ONE. 2020;15:e0236921 pubmed publisher

product information

Antigen :

CD11b

Apps. Abbrev. :

Flow Cytometry, IP, Block

Cat # :

301425

Clone :

CBRM1/5

Item :

Ultra-LEAF™ Purified anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

100 μg

Price (USD) :

270 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

ULEAF

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin 9 . Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1 1 . The CBRM1/5 antibody binds specifically to the activated form of CD11b. The Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301425 and 301426 ).