APC/Fire™ 750 anti-human CD11b (activated) | BioLegend 301420 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

APC/Fire™ 750 anti-human CD11b (activated)

catalog :

301420

quantity :

100 tests

price :

330 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

CBRM1/5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-23934, sc-23934 L
Exbio: 1P-172-T100, 11-172-C100, 1P-172-T025, 11-172-C025, 12-172-C100
Invitrogen: 17-0113-41, 16-0113-025, 17-0113-42, 25-0113-41, 56-0113-42, 25-0113-42, 63-0113-42, 62-0113-42, 16-0113-050, 46-0113-42, 12-0113-42, 14-0113-81, 62-0113-41, 16-0113-82, 11-0113-42, 16-0113-38
OriGene: TA320385

reactivity :

human

application :

flow cytometry

citations: 9

Reference
Agha O, Mueller Immergluck A, Liu M, Zhang H, Theologis A, Clark A, et al. Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations. JOR Spine. 2020;3:e1091 pubmed publisher
Müller Edenborn B, Frick R, Piegeler T, Schläpfer M, Roth Z graggen B, Schlicker A, et al. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. Br J Anaesth. 2015;114:143-9 pubmed publisher
Cash J, Bena S, Headland S, McArthur S, Brancaleone V, Perretti M. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO Rep. 2013;14:999-1007 pubmed publisher
Eleftheriou D, Ganesan V, Hong Y, Klein N, Brogan P. Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study. Neurology. 2012;79:2089-96 pubmed publisher
Koleva R, Ficarro S, Radomska H, Carrasco Alfonso M, Alberta J, Webber J, et al. C/EBP? and DEK coordinately regulate myeloid differentiation. Blood. 2012;119:4878-88 pubmed publisher
Wilson R, Winter S, Spees A, Winter M, Nishimori J, Sanchez J, et al. The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Infect Immun. 2011;79:830-7 pubmed publisher
Pillay J, Ramakers B, Kamp V, Loi A, Lam S, Hietbrink F, et al. Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. J Leukoc Biol. 2010;88:211-20 pubmed publisher
Bryn T, Mahic M, Enserink J, Schwede F, Aandahl E, Tasken K. The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol. 2006;176:7361-70 pubmed
Barthel S, Jarjour N, Mosher D, Johansson M. Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol. 2006;35:378-86 pubmed

product information

Antigen :

CD11b

Apps. Abbrev. :

Flow Cytometry

Cat # :

301420

Clone :

CBRM1/5

Item :

APC/Fire™ 750 anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

100 tests

Price (USD) :

330 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

APC_F750

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin 9 . Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1 1 . The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).