PerCP/Cyanine5.5 anti-human CD11b (activated) | BioLegend 301417 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PerCP/Cyanine5.5 anti-human CD11b (activated)

catalog :

301417

quantity :

25 tests

price :

132 USD

clonality :

monoclonal

host :

mouse

conjugate :

PerCP/Cy5.5

clone name :

CBRM1/5

The same clone is also sold as:

OriGene: TA320385
Santa Cruz Biotechnology: sc-23934 L, sc-23934
Exbio: 1P-172-T025, 12-172-C100, 1P-172-T100, 11-172-C025, 11-172-C100
Invitrogen: 56-0113-42, 25-0113-42, 12-0113-42, 25-0113-41, 16-0113-38, 62-0113-42, 16-0113-82, 63-0113-42, 16-0113-050, 11-0113-42, 16-0113-025, 17-0113-41, 17-0113-42, 14-0113-81, 46-0113-42, 62-0113-41

reactivity :

human

application :

flow cytometry

citations: 9

Reference
Zhong J, Scholz T, Yau A, Guérard S, Huffmeier U, Burkhardt H, et al. Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes. Sci Adv. 2018;4:eaas9864 pubmed publisher
Müller Edenborn B, Frick R, Piegeler T, Schläpfer M, Roth Z graggen B, Schlicker A, et al. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. Br J Anaesth. 2015;114:143-9 pubmed publisher
Cash J, Bena S, Headland S, McArthur S, Brancaleone V, Perretti M. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO Rep. 2013;14:999-1007 pubmed publisher
Eleftheriou D, Ganesan V, Hong Y, Klein N, Brogan P. Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study. Neurology. 2012;79:2089-96 pubmed publisher
Koleva R, Ficarro S, Radomska H, Carrasco Alfonso M, Alberta J, Webber J, et al. C/EBP? and DEK coordinately regulate myeloid differentiation. Blood. 2012;119:4878-88 pubmed publisher
Wilson R, Winter S, Spees A, Winter M, Nishimori J, Sanchez J, et al. The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Infect Immun. 2011;79:830-7 pubmed publisher
Pillay J, Ramakers B, Kamp V, Loi A, Lam S, Hietbrink F, et al. Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. J Leukoc Biol. 2010;88:211-20 pubmed publisher
Bryn T, Mahic M, Enserink J, Schwede F, Aandahl E, Tasken K. The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol. 2006;176:7361-70 pubmed
Barthel S, Jarjour N, Mosher D, Johansson M. Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol. 2006;35:378-86 pubmed

product information

Antigen :

CD11b

Apps. Abbrev. :

Flow Cytometry

Cat # :

301417

Clone :

CBRM1/5

Item :

PerCP/Cyanine5.5 anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

25 tests

Price (USD) :

132 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PERCP_CYANINE5.5

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin 9 . Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1 1 . The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).