PE/Cyanine7 anti-human CD11b (activated) | BioLegend 301412 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Cyanine7 anti-human CD11b (activated)

catalog :

301412

quantity :

100 tests

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CBRM1/5

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 2

Reference
Zheng Q, Xu F, Yang Y, Sun D, Zhong Y, Wu S, et al. C5a/C5aR1 mediates IMQ-induced psoriasiform skin inflammation by promoting IL-17A production from γδ-T cells. FASEB J. 2020;34:10590-10604 pubmed publisher
Zheng Q, Liang S, Xu F, Li G, Luo N, Wu S, et al. C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis. Front Immunol. 2019;10:1866 pubmed publisher

product information

Antigen :

CD11b

Apps. Abbrev. :

Cat # :

301412

Clone :

CBRM1/5

Item :

PE/Cyanine7 anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

100 tests

Price (USD) :

335 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PE_CYANINE7

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin^9.Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1^1. The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).;

more info or order :

BioLegend product webpage