APC anti-human CD11b (activated) | BioLegend 301409 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

APC anti-human CD11b (activated)

catalog :

301409

quantity :

25 tests

price :

142 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

CBRM1/5

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 6

Reference
Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses. J Virol. 2020;: pubmed publisher
Kimbrough D, Wang S, Wright L, Mani S, Kasiganesan H, LaRue A, et al. HDAC inhibition helps post-MI healing by modulating macrophage polarization. J Mol Cell Cardiol. 2018;119:51-63 pubmed publisher
Sander J, Schmidt S, Cirovic B, McGovern N, Papantonopoulou O, Hardt A, et al. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017;47:1051-1066.e12 pubmed publisher
Johnson C, O Brien X, Byrd A, Parisi V, Loosely A, Li W, et al. Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response. J Immunol. 2017;198:318-334 pubmed publisher
Bratcher P, Rowe S, Reeves G, Roberts T, Szul T, Harris W, et al. Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor. J Cyst Fibros. 2016;15:67-73 pubmed publisher
Caiado F, Carvalho T, Rosa I, Remédio L, Costa A, Matos J, et al. Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer. Cancer Res. 2013;73:4233-46 pubmed publisher

product information

Antigen :

CD11b

Apps. Abbrev. :

Cat # :

301409

Clone :

CBRM1/5

Item :

APC anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

25 tests

Price (USD) :

142 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

APC

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin^9.Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1^1. The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).;

more info or order :

BioLegend product webpage