FITC anti-human CD11b (activated) | BioLegend 301404 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

FITC anti-human CD11b (activated)

catalog :

301404

quantity :

100 tests

price :

220 USD

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

CBRM1/5

The same clone is also sold as:

OriGene: TA320385
Invitrogen: 56-0113-42, 25-0113-42, 11-0113-42, 17-0113-42, 62-0113-41, 63-0113-42, 14-0113-81, 16-0113-82, 25-0113-41, 46-0113-42, 62-0113-42, 17-0113-41, 16-0113-38, 12-0113-42, 16-0113-050, 16-0113-025
Santa Cruz Biotechnology: sc-23934, sc-23934 L
Exbio: 12-172-C100, 1P-172-T100, 1P-172-T025, 11-172-C100, 11-172-C025

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Mahajan A, Grüneboom A, Petru L, Podolska M, Kling L, Maueröder C, et al. Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface. J Leukoc Biol. 2019;105:1087-1098 pubmed publisher
Li Y, Teteloshvili N, Tan S, Rao S, Han A, Yang Y, et al. Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells. Front Immunol. 2019;10:63 pubmed publisher
Johnson C, O Brien X, Byrd A, Parisi V, Loosely A, Li W, et al. Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response. J Immunol. 2017;198:318-334 pubmed publisher
Yin S, Jian F, Chen Y, Chien S, Hsieh M, Hsiao P, et al. Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis. Nat Commun. 2016;7:11311 pubmed publisher
Müller Edenborn B, Frick R, Piegeler T, Schläpfer M, Roth Z graggen B, Schlicker A, et al. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. Br J Anaesth. 2015;114:143-9 pubmed publisher
Reis E, Chen H, Sfyroera G, Monk P, Köhl J, Ricklin D, et al. C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay. J Immunol. 2012;189:4797-805 pubmed publisher
Bryn T, Mahic M, Enserink J, Schwede F, Aandahl E, Tasken K. The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol. 2006;176:7361-70 pubmed

product information

Antigen :

CD11b

Apps. Abbrev. :

Flow Cytometry

Cat # :

301404

Clone :

CBRM1/5

Item :

FITC anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

100 tests

Price (USD) :

220 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

FITC

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin 9 . Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1 1 . The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).