Purified anti-human CD11b (activated) | BioLegend 301402 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-human CD11b (activated)

catalog :

301402

quantity :

100 μg

price :

105 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CBRM1/5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-23934, sc-23934 L
OriGene: TA320385
Exbio: 11-172-C025, 1P-172-T100, 1P-172-T025, 11-172-C100, 12-172-C100
Invitrogen: 25-0113-41, 62-0113-41, 14-0113-81, 16-0113-050, 16-0113-38, 63-0113-42, 56-0113-42, 25-0113-42, 12-0113-42, 16-0113-025, 46-0113-42, 17-0113-41, 62-0113-42, 11-0113-42, 16-0113-82, 17-0113-42

reactivity :

human

application :

immunoprecipitation, flow cytometry

citations: 16

Reference
Carroll D, Cao Y, Bochner B, O Sullivan J. Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro. Front Immunol. 2021;12:737988 pubmed publisher
Rosental B, Kowarsky M, Seita J, Corey D, Ishizuka K, Palmeri K, et al. Complex mammalian-like haematopoietic system found in a colonial chordate. Nature. 2018;564:425-429 pubmed publisher
Tseng H, Samarelli A, Kammerer P, Scholze S, Ziegler T, Immler R, et al. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. J Cell Sci. 2018;131: pubmed publisher
Tseng A, Kim K, Li J, Cho J. Myeloperoxidase Negatively Regulates Neutrophil-Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation. Front Med (Lausanne). 2018;5:134 pubmed publisher
Alflen A, Stadler N, Aranda Lopez P, Teschner D, Theobald M, HeÃŸ G, et al. Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses. Sci Rep. 2018;8:5558 pubmed publisher
Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, et al. Skap2 is required for ?2 integrin-mediated neutrophil recruitment and functions. J Exp Med. 2017;214:851-874 pubmed publisher
Davis R, Sharma S, ConceiÃ§Ã£o J, Carneiro P, Novais F, Scott P, et al. Phenotypic and functional characteristics of HLA-DR+ neutrophils in Brazilians with cutaneous leishmaniasis. J Leukoc Biol. 2017;101:739-749 pubmed publisher
Medraño Fernández I, Reyes R, Olazabal I, Rodriguez E, Sanchez Madrid F, Boussiotis V, et al. RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Cell Mol Life Sci. 2013;70:2395-410 pubmed publisher
Kamp V, Pillay J, Lammers J, Pickkers P, Ulfman L, Koenderman L. Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion. J Leukoc Biol. 2012;92:1011-20 pubmed publisher
Curran C, Bertics P. Human eosinophils express RAGE, produce RAGE ligands, exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand, S100B. Int Immunol. 2011;23:713-28 pubmed publisher
Theodoridis A, Eich C, Figdor C, Steinkasserer A. Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Blood. 2011;118:107-15 pubmed publisher
Cavnar P, Berthier E, Beebe D, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. J Cell Biol. 2011;193:465-73 pubmed publisher
Wilson R, Winter S, Spees A, Winter M, Nishimori J, Sanchez J, et al. The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Infect Immun. 2011;79:830-7 pubmed publisher
Pillay J, Ramakers B, Kamp V, Loi A, Lam S, Hietbrink F, et al. Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. J Leukoc Biol. 2010;88:211-20 pubmed publisher
Bryn T, Mahic M, Enserink J, Schwede F, Aandahl E, Tasken K. The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol. 2006;176:7361-70 pubmed
Barthel S, Jarjour N, Mosher D, Johansson M. Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol. 2006;35:378-86 pubmed

product information

Antigen :

CD11b

Apps. Abbrev. :

Flow Cytometry, IP

Cat # :

301402

Clone :

CBRM1/5

Item :

Purified anti-human CD11b (activated)

Isotype :

Mouse IgG1, κ

Other Names :

Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM

Size :

100 μg

Price (USD) :

105 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PURE

Application Notes :

The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. Clone CBRM1/5 binds the I domain, close to the ligand binding site. It recognizes a conformational change of the integrin 9 . Additional reported applications (for the relevant formats) include: immunoprecipitation, and blocking cell adhesion to fibrinogen and ICAM-1 1 . The CBRM1/5 antibody binds specifically to the activated form of CD11b. The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301408).