product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human CD11a
catalog :
301202
quantity :
100 μg
price :
102 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HI111
reactivity :
human, dogs
application :
western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s1
Matsumoto K, Kurasawa T, Yoshimoto K, Suzuki K, Takeuchi T. Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses. Arthritis Res Ther. 2021;23:136 pubmed publisher
  • flow cytometry; dogs; loading ...; fig 4c
McGill J, Wang Y, Ganta C, Boorgula G, Ganta R. Antigen-Specific CD4+CD8+ Double-Positive T Cells Are Increased in the Blood and Spleen During Ehrlichia chaffeensis Infection in the Canine Host. Front Immunol. 2018;9:1585 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml; loading ...; fig 3b
Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3b
Johnson D, Wayt J, Wilson J, Donaldson J. Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking. J Cell Sci. 2017;130:2405-2415 pubmed publisher
  • flow cytometry; human; fig 5
Difranco K, Johnson Farley N, Bertino J, Elson D, Vega B, Belinka B, et al. LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes. Leuk Res. 2015;39:649-56 pubmed publisher
Olety B, Peters P, Wu Y, Usami Y, Gottlinger H. HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2. Sci Adv. 2021;7:eabj7398 pubmed publisher
García Salido A, Cuenca Carcelén S, Castillo Robleda A. CD64, CD11a and CD18 leukocytes expression in children with SARS-CoV-2 multisystem inflammatory syndrome versus children with Kawasaki disease: Similar but not the same. Med Clin (Barc). 2021;156:89-91 pubmed publisher
Ristow L, Tran V, Schwartz K, Pankratz L, Mehle A, Sauer J, et al. The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity. MBio. 2019;10: pubmed publisher
Stoeckius M, Zheng S, Houck Loomis B, Hao S, Yeung B, Mauck W, et al. Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. Genome Biol. 2018;19:224 pubmed publisher
Bouafia A, Lofek S, Bruneau J, Chentout L, Lamrini H, Trinquand A, et al. Loss of ARHGEF1 causes a human primary antibody deficiency. J Clin Invest. 2019;129:1047-1060 pubmed publisher
Ran L, Zeng Y, Wang S, Zhang D, Hong M, Li S, et al. Effect of co‑culture with amniotic epithelial cells on the biological characteristics of amniotic mesenchymal stem cells. Mol Med Rep. 2018;18:723-732 pubmed publisher
Li N, Yang H, Wang M, Lü S, Zhang Y, Long M. Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling. Mol Biol Cell. 2018;29:408-418 pubmed publisher
Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed publisher
Resheq Y, Menzner A, Bosch J, Tickle J, Li K, Wilhelm A, et al. Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13. J Immunol. 2017;199:1672-1681 pubmed publisher
Mace E, Orange J. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. J Vis Exp. 2014;: pubmed publisher
product information
Antigen :
CD11a
Apps. Abbrev. :
FC, IHC-F, WB, Block
Cat # :
301202
Clone :
HI111
Item :
Purified anti-human CD11a
Isotype :
Mouse IgG1, κ
Other Names :
LFA-1α chain, Integrin αL subunit, αL Integrin, ITGAL
Size :
100 μg
Price (USD) :
102 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Application Notes :
Clone HI111 epitope maps to the top region of the I domain that is close to the putative ligand-binding site surrounding the MIDAS (metal ion-dependent adhesion site). HI111 is specific for the closed confirmation of the integrin^8. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections, Western blotting^2, and blocking of cell-cell interaction and inhibition the binding of ICAM-1^4. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 301233 & 301234).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA