Treg-Protector™ (anti-ARTC2 Nanobody) | BioLegend 149803 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Treg-Protector™ (anti-ARTC2 Nanobody)

catalog :

149803

quantity :

500 μg

price :

464 USD

clonality :

recombinant

conjugate :

nonconjugated

clone name :

S+16a

reactivity :

mouse

application :

neutralization

more info or order :

BioLegend product webpage

citations: 6

Reference
Lin Y, Duong H, Limary A, Kim E, Hsu P, Patel S, et al. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity. 2023;56:207-223.e8 pubmed publisher
Wanhainen K, Peng C, Zhou M, Macedo B, O Flanagan S, Yang T, et al. P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy. Cancer Immunol Res. 2022;10:871-884 pubmed publisher
Wennerberg E, Mukherjee S, Spada S, Hung C, Agrusa C, Chen C, et al. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Sci Transl Med. 2022;14:eabe8195 pubmed publisher
Borges da Silva H, Peng C, Wang H, Wanhainen K, Ma C, Lopez S, et al. Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β. Immunity. 2020;53:158-171.e6 pubmed publisher
K xfc nzli M, Schreiner D, Pereboom T, Swarnalekha N, Litzler L, L xf6 tscher J, et al. Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity. Sci Immunol. 2020;5: pubmed publisher
Liu Q, Kim C. Control of Tissue-Resident Invariant NKT Cells by Vitamin A Metabolites and P2X7-Mediated Cell Death. J Immunol. 2019;203:1189-1197 pubmed publisher

product information

Antigen :

ARTC2

Apps. Abbrev. :

Block

Cat # :

149803

Clone :

S+16a

Item :

Treg-Protector™ (anti-ARTC2 Nanobody)

Isotype :

Llama VH Ig

Other Names :

ART2.2, Art2b, Art, Rt6, Rt-6, Ly92b, Rt6-2

Size :

500 μg

Price (USD) :

464 USD

Reactivity :

Mouse

Clonality :

Recombinant

Conjugate/Tag/Label :

SOLUTION

Immunogen :

Expression vector encoding full length mouse ARTC2.

Application Notes :

Treg-Protector™ (S+16a Nanobody) is a recombinant llama VH Ig domain that binds to the ADP-ribosyltransferase ARTC2, which reversibly blocks its enzymatic activity and protects ARTC2^+ cells from NAD^+-induced cell death (NICD), which is caused by the release of NAD^+ by cells that die during the preparation of primary lymphocytes. The S+16a nanobody has been demonstrated to protect a variety of cell types including Tregs, NKT cells, and tissue-resident memory T cells^8.;

more info or order :

BioLegend product webpage