product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 488 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
catalog :
144611
quantity :
25 μg
price :
77 USD
clonality :
monoclonal
host :
rat
conjugate :
AF488
clone name :
GL7
reactivity :
mouse
application :
immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1o
Lee A, Pingali S, Pinilla Ibarz J, Atchison M, Koumenis C, Argon Y, et al. Loss of AID exacerbates the malignant progression of CLL. Leukemia. 2022;36:2430-2442 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 9a
  • flow cytometry; mouse; 1:200; loading ...; fig s35a
Satofuka H, Abe S, Moriwaki T, Okada A, Kazuki K, Tanaka H, et al. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci. Nat Commun. 2022;13:1841 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1j
Kim E, Attia Z, Woodfint R, Zeng C, Kim S, Steiner H, et al. Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; mouse; 1:200; fig 1l
Zhang S, Li L, Xie D, Reddy S, Sleasman J, Ma L, et al. Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1. Front Immunol. 2021;12:620437 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4f
Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, et al. Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. J Clin Invest. 2020;130:3422-3436 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Zhang Q, Xiang L, Zaman M, Dong W, He G, Deng G. Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus. Front Immunol. 2019;10:3020 pubmed publisher
  • flow cytometry; mouse; 1:120; loading ...; fig 1a
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Grootjans J, Krupka N, Hosomi S, Matute J, Hanley T, Saveljeva S, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019;363:993-998 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3b
Faliti C, Gualtierotti R, Rottoli E, Gerosa M, Perruzza L, Romagnani A, et al. P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus. J Exp Med. 2019;216:317-336 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3
  • flow cytometry; mouse; loading ...; fig 1b
Tan H, Jegaskanda S, Juno J, Esterbauer R, Wong J, Kelly H, et al. Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem. J Clin Invest. 2019;129:850-862 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7b
Theisen D, Davidson J, Briseño C, Gargaro M, Lauron E, Wang Q, et al. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. 2018;362:694-699 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3b
  • immunohistochemistry; mouse; loading ...; fig s3b
Rezende R, Lanser A, Rubino S, Kuhn C, Skillin N, Moreira T, et al. γδ T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018;9:3151 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4e
Tang C, Chang S, Paton A, Paton J, Gabrilovich D, Ploegh H, et al. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol. 2018;217:1739-1755 pubmed publisher
L xfc tge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, et al. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol. 2023;24:1149-1160 pubmed publisher
Yazicioglu Y, Marin E, Sandhu C, Galiani S, Raza I, Ali M, et al. Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis. Nat Immunol. 2023;24:991-1006 pubmed publisher
D xf6 lz M, Hasiuk M, Gagnon J, Kornete M, Marone R, Bantug G, et al. Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells. iScience. 2022;25:105372 pubmed publisher
He C, Yang J, Hong W, Chen Z, Peng D, Lei H, et al. A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant. Nat Commun. 2022;13:5459 pubmed publisher
Park J, Lee D, Yang S, Jeong H, Na H, Cho K, et al. Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells. J Transl Med. 2022;20:85 pubmed publisher
Kodali S, Li M, Budai M, Chen M, Wang J. Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. J Immunol. 2022;208:1085-1098 pubmed publisher
Alameh M, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore J, et al. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Immunity. 2021;54:2877-2892.e7 pubmed publisher
Li X, Zeng Q, Wang S, Li M, Chen X, Huang Y, et al. CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis. Front Immunol. 2021;12:779560 pubmed publisher
Trindade B, Ceglia S, Berthelette A, Raso F, Howley K, Muppidi J, et al. The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. Immunity. 2021;54:2273-2287.e6 pubmed publisher
de Reuver R, Dierick E, Wiernicki B, Staes K, Seys L, De Meester E, et al. ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. Cell Rep. 2021;36:109500 pubmed publisher
Jiang W, Wong J, Tan H, Kelly H, Whitney P, Barr I, et al. Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells. Sci Rep. 2021;11:1864 pubmed publisher
Kaw S, Ananth S, Tsopoulidis N, Morath K, Coban B, Hohenberger R, et al. HIV-1 infection of CD4 T cells impairs antigen-specific B cell function. EMBO J. 2020;39:e105594 pubmed publisher
Lee G, Jun Y, Yoo H, Jeon Y, Lee D, Lee S, et al. Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation. Oncoimmunology. 2020;9:1746553 pubmed publisher
Laczkó D, Hogan M, Toulmin S, Hicks P, Lederer K, Gaudette B, et al. A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. Immunity. 2020;53:724-732.e7 pubmed publisher
McNamara H, Idris A, Sutton H, Vistein R, Flynn B, Cai Y, et al. Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response. Cell Host Microbe. 2020;: pubmed publisher
Sangesland M, Ronsard L, Kazer S, Bals J, Boyoglu Barnum S, Yousif A, et al. Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. Immunity. 2019;51:735-749.e8 pubmed publisher
Vono M, Eberhardt C, Auderset F, Mastelic Gavillet B, Lemeille S, Christensen D, et al. Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers. Cell Rep. 2019;28:1773-1784.e5 pubmed publisher
Liu Y, Tan H, Koutsakos M, Jegaskanda S, Esterbauer R, Tilmanis D, et al. Cross-lineage protection by human antibodies binding the influenza B hemagglutinin. Nat Commun. 2019;10:324 pubmed publisher
Yang Z, Xu M, Jia Z, Zhang Y, Wang L, Zhang H, et al. A novel antigen delivery system induces strong humoral and CTL immune responses. Biomaterials. 2017;134:51-63 pubmed publisher
Sebastian M, Lopez Ocasio M, Metidji A, RIEDER S, Shevach E, Thornton A. Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol. 2016;196:144-55 pubmed publisher
product information
Antigen :
GL7
Apps. Abbrev. :
FC, IHC-F
Cat # :
144611
Clone :
GL7
Item :
Alexa Fluor® 488 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
Isotype :
Rat IgM, κ
Other Names :
Ly77, T and B cell activation marker
Size :
25 μg
Price (USD) :
77 USD
Reactivity :
Mouse, Human
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
A488
Immunogen :
LPS activated DBA/J mouse B cells
Application Notes :
The GL7 antibody does not block the binding of CD22 with sulfated a2-6-sialyl-LacNAc.Cross-reactivity to ferret has been reported by a collaborator, but not verified in house.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA