product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
catalog :
144602
quantity :
500 μg
price :
293 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
GL7
reactivity :
mouse
application :
ELISA, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1o
Lee A, Pingali S, Pinilla Ibarz J, Atchison M, Koumenis C, Argon Y, et al. Loss of AID exacerbates the malignant progression of CLL. Leukemia. 2022;36:2430-2442 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 9a
  • flow cytometry; mouse; 1:200; loading ...; fig s35a
Satofuka H, Abe S, Moriwaki T, Okada A, Kazuki K, Tanaka H, et al. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci. Nat Commun. 2022;13:1841 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1j
Kim E, Attia Z, Woodfint R, Zeng C, Kim S, Steiner H, et al. Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; mouse; 1:200; fig 1l
Zhang S, Li L, Xie D, Reddy S, Sleasman J, Ma L, et al. Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1. Front Immunol. 2021;12:620437 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4f
Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, et al. Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. J Clin Invest. 2020;130:3422-3436 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Zhang Q, Xiang L, Zaman M, Dong W, He G, Deng G. Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus. Front Immunol. 2019;10:3020 pubmed publisher
  • flow cytometry; mouse; 1:120; loading ...; fig 1a
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Grootjans J, Krupka N, Hosomi S, Matute J, Hanley T, Saveljeva S, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019;363:993-998 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3b
Faliti C, Gualtierotti R, Rottoli E, Gerosa M, Perruzza L, Romagnani A, et al. P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus. J Exp Med. 2019;216:317-336 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3
  • flow cytometry; mouse; loading ...; fig 1b
Tan H, Jegaskanda S, Juno J, Esterbauer R, Wong J, Kelly H, et al. Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem. J Clin Invest. 2019;129:850-862 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7b
Theisen D, Davidson J, Briseño C, Gargaro M, Lauron E, Wang Q, et al. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. 2018;362:694-699 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3b
  • immunohistochemistry; mouse; loading ...; fig s3b
Rezende R, Lanser A, Rubino S, Kuhn C, Skillin N, Moreira T, et al. γδ T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018;9:3151 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4e
Tang C, Chang S, Paton A, Paton J, Gabrilovich D, Ploegh H, et al. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol. 2018;217:1739-1755 pubmed publisher
  • flow cytometry; mouse; loading ...
Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s1c
Martínez Martín N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, et al. A switch from canonical to noncanonical autophagy shapes B cell responses. Science. 2017;355:641-647 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Forster M, Farrington K, Petrov J, Belle J, Mindt B, Witalis M, et al. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response. J Leukoc Biol. 2017;101:643-654 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s6
Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest. 2016;126:4626-4639 pubmed publisher
  • flow cytometry; mouse; fig s2
Wu S, Majeed S, Evans T, Camus M, Wong N, Schollmeier Y, et al. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016;113:9816-21 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Leeth C, Racine J, Chapman H, Arpa B, Carrillo J, Carrascal J, et al. B-lymphocytes expressing an Ig specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice. Diabetes. 2016;65:1977-1987 pubmed publisher
Pang Z, Yan W, Yang J, Li Q, Guo Y, Zhou D, et al. Multifunctional Gold Nanoclusters for Effective Targeting, Near-Infrared Fluorescence Imaging, Diagnosis, and Treatment of Cancer Lymphatic Metastasis. ACS Nano. 2022;16:16019-16037 pubmed publisher
Avalos A, Tietsort J, Suwankitwat N, Woods J, Jackson S, Christodoulou A, et al. Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. JCI Insight. 2022;7: pubmed publisher
Mathur S, Wang J, Seehus C, Poirier F, Crosson T, Hsieh Y, et al. Nociceptor neurons promote IgE class switch in B cells. JCI Insight. 2021;6: pubmed publisher
Firmino N, Cederberg R, Lee C, Shi R, Wadsworth B, Franks S, et al. Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer. Oncoimmunology. 2021;10:1959978 pubmed publisher
Kobayashi A, Ito A, Shirakawa I, Tamura A, Tomono S, Shindou H, et al. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity. Front Immunol. 2021;12:650856 pubmed publisher
Prabakaran T, Troldborg A, Kumpunya S, Alee I, Marinković E, Windross S, et al. A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. EBioMedicine. 2021;66:103314 pubmed publisher
Landuyt A, Klocke B, Duck L, Kemp K, Muir R, Jennings M, et al. ICOS ligand and IL-10 synergize to promote host-microbiota mutualism. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed publisher
Son Y, Cheon I, Goplen N, Dent A, Sun J. Inhibition of stearoyl-CoA desaturases suppresses follicular help T- and germinal center B- cell responses. Eur J Immunol. 2020;50:1067-1077 pubmed publisher
Zelazowska M, Dong Q, Plummer J, Zhong Y, Liu B, Krug L, et al. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance. 2020;3: pubmed publisher
Abboud G, Choi S, Kanda N, Zeumer Spataro L, Roopenian D, Morel L. Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis. Front Immunol. 2018;9:1973 pubmed publisher
Crawford G, Hayes M, Seoane R, Ward S, Dalessandri T, Lai C, et al. Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response. Nat Immunol. 2018;19:859-870 pubmed publisher
Fonseca J, McCaffery J, Caceres J, Kashentseva E, Singh B, Dmitriev I, et al. Inclusion of the murine IgGκ signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine. Vaccine. 2018;36:2799-2808 pubmed publisher
Duncan C, Kondilis Mangum H, Grimm S, Bushel P, Chrysovergis K, Roberts J, et al. Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells. G3 (Bethesda). 2018;8:805-813 pubmed publisher
Ma W, Liu Q, Yang J, Yang Y, Zhao Z, Ma H, et al. A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization. Sci Rep. 2017;7:15246 pubmed publisher
Niss Arfelt K, Barington L, Benned Jensen T, Kubale V, Kovalchuk A, Daugvilaite V, et al. EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies. Blood. 2017;129:866-878 pubmed publisher
product information
Antigen :
GL7
Apps. Abbrev. :
FC, ELISA, IHC-F, IP
Cat # :
144602
Clone :
GL7
Item :
Purified anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
Isotype :
Rat IgM, κ
Other Names :
Ly77, T and B cell activation marker
Size :
500 μg
Price (USD) :
293 USD
Reactivity :
Mouse, Human
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PURE
Immunogen :
LPS activated DBA/J mouse B cells
Application Notes :
The GL7 antibody does not block the binding of CD22 with sulfated a2-6-sialyl-LacNAc.Cross-reactivity to ferret has been reported by a collaborator, but not verified in house.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA