product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 488 anti-mouse CD206 (MMR)
catalog :
141710
quantity :
100 μg
price :
293 USD
clonality :
monoclonal
host :
rat
conjugate :
AF488
clone name :
C068C2
reactivity :
mouse
application :
immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 114
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 1c
Beider K, Voevoda Dimenshtein V, Zoabi A, Rosenberg E, Magen H, Ostrovsky O, et al. CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. J Hematol Oncol. 2022;15:144 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Kawakubo A, Miyagi M, Yokozeki Y, Nakawaki M, Takano S, Satoh M, et al. Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model. Int J Immunopathol Pharmacol. 2022;36:3946320221103792 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c, s2b
Pan C, Wu Q, Wang S, Mei Z, Zhang L, Gao X, et al. Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma. Oncoimmunology. 2022;11:2073010 pubmed publisher
  • flow cytometry; mouse; fig 2f
Larue M, Parker S, Puccini J, Cammer M, Kimmelman A, Bar Sagi D. Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer. Proc Natl Acad Sci U S A. 2022;119:e2119168119 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3f
Bhattacharjee O, Ayyangar U, Kurbet A, Lakshmanan V, Palakodeti D, Ginhoux F, et al. Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Front Immunol. 2021;12:718005 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s3b
Yang C, Lei L, Collins J, Briones M, Ma L, Sturdevant G, et al. Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor. Nat Commun. 2021;12:5454 pubmed publisher
  • flow cytometry; mouse; loading ...
Forman R, Logunova L, Smith H, Wemyss K, Mair I, Boon L, et al. Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. PLoS Pathog. 2021;17:e1009768 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
Gao D, Salomonis N, Henderlight M, Woods C, Thakkar K, Grom A, et al. IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI Insight. 2021;6: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5g
Mathä L, Romera Hernandez M, Steer C, Yin Y, Orangi M, Shim H, et al. Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity. Front Immunol. 2021;12:679509 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
Van De Velde L, Allen E, Crawford J, Wilson T, Guy C, Russier M, et al. Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells. Cancer Res. 2021;81:5047-5059 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Nordlohne J, Hulsmann I, Schwafertz S, Zgrajek J, Grundmann M, von Vietinghoff S, et al. A flow cytometry approach reveals heterogeneity in conventional subsets of murine renal mononuclear phagocytes. Sci Rep. 2021;11:13251 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
Amoozgar Z, Kloepper J, Ren J, Tay R, Kazer S, Kiner E, et al. Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nat Commun. 2021;12:2582 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig 6b
Manrique Acevedo C, Padilla J, Naz H, Woodford M, Ghiarone T, Aroor A, et al. Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice. Front Physiol. 2021;12:588358 pubmed publisher
  • flow cytometry; mouse
Chu A, Kok S, TSUI J, Lin M, Aguirre B, Wadehra M. Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface. J Reprod Immunol. 2021;145:103309 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s4f
Wolfsberger J, Sakil H, Zhou L, van Bree N, Baldisseri E, de Souza Ferreira S, et al. TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6d
Zhang Y, Liu J, Wang X, Zhang J, Xie C. Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury. Aging (Albany NY). 2021;13:6752-6764 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Chen J, Cao X, Li B, Zhao Z, Chen S, Lai S, et al. Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance. Front Immunol. 2020;11:621757 pubmed publisher
  • flow cytometry; mouse; 1:50; fig 7
Mpekris F, Panagi M, Voutouri C, Martin J, Samuel R, Takahashi S, et al. Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano-immunotherapy in Breast Cancer Lung Metastasis. Adv Sci (Weinh). 2021;8:2001917 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig e10e
Mastorakos P, Mihelson N, Luby M, Burks S, Johnson K, Hsia A, et al. Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. Nat Neurosci. 2021;24:245-258 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Ogura Y, Tajiri K, Murakoshi N, Xu D, Yonebayashi S, Li S, et al. Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice. Int J Mol Sci. 2021;22: pubmed publisher
  • flow cytometry; mouse; 1:100; fig 4a
Boulet N, Luijten I, Cannon B, Nedergaard J. Thermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition. Am J Physiol Endocrinol Metab. 2020;: pubmed publisher
  • flow cytometry; mouse; loading ...
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2i
Hall B, Gleiberman A, Strom E, Krasnov P, Frescas D, Vujcic S, et al. Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. Aging Cell. 2020;19:e13219 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d, 2e
Zheng D, Gao F, Cheng Q, Bao P, Dong X, Fan J, et al. A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat Commun. 2020;11:1985 pubmed publisher
  • flow cytometry; mouse; loading ...
Chao Y, Liang C, Tao H, Du Y, Wu D, Dong Z, et al. Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses. Sci Adv. 2020;6:eaaz4204 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a
Kubli S, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, et al. AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. Proc Natl Acad Sci U S A. 2019;116:3604-3613 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Liu M, O Connor R, Trefely S, Graham K, Snyder N, Beatty G. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal. Nat Immunol. 2019;20:265-275 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin G, Shurin M, et al. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019;116:1361-1369 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4
Cortés Selva D, Elvington A, Ready A, Rajwa B, Pearce E, Randolph G, et al. Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype. Front Immunol. 2018;9:2580 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Ushio A, Arakaki R, Otsuka K, Yamada A, Tsunematsu T, Kudo Y, et al. CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome. Front Immunol. 2018;9:2594 pubmed publisher
  • flow cytometry; mouse; fig 2e
Cabron A, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, et al. Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells. J Immunol. 2018;201:3106-3118 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Kyung D, Sung H, Kim Y, Kim K, Cho S, Choi J, et al. Global transcriptome analysis identifies weight regain-induced activation of adaptive immune responses in white adipose tissue of mice. Int J Obes (Lond). 2018;42:755-764 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3g
Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1b
Macdougall C, Wood E, Loschko J, Scagliotti V, Cassidy F, Robinson M, et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab. 2018;27:588-601.e4 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Panduro M, Benoist C, Mathis D. Treg cells limit IFN-? production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2018;115:E2585-E2593 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 4a
Zhu Y, Zhou J, Feng Y, Chen L, Zhang L, Yang F, et al. Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. Front Immunol. 2018;9:87 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d
Perry C, Muñoz Rojas A, Meeth K, Kellman L, Amezquita R, Thakral D, et al. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018;215:877-893 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Daley D, Mani V, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214:1711-1724 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5c
A Gonzalez N, Quintana J, Garcia Silva S, Mazariegos M, González de la Aleja A, Nicolás Ávila J, et al. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017;214:1281-1296 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4f
Daley D, Mani V, Mohan N, Akkad N, Ochi A, Heindel D, et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med. 2017;23:556-567 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5d
Hammer A, Yang G, Friedrich J, Kovacs A, Lee D, Grave K, et al. Role of the receptor Mas in macrophage-mediated inflammation in vivo. Proc Natl Acad Sci U S A. 2016;113:14109-14114 pubmed
  • flow cytometry; mouse; fig 3
Coppo M, Chinenov Y, Sacta M, Rogatsky I. The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis. Nat Commun. 2016;7:12254 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 3
Xue J, Sharma V, Hsieh M, Chawla A, Murali R, Pandol S, et al. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun. 2015;6:7158 pubmed publisher
Mitsui K, Hishiyama S, Jain A, Kotoda Y, Abe M, Matsukawa T, et al. Role of macrophage autophagy in postoperative pain and inflammation in mice. J Neuroinflammation. 2023;20:102 pubmed publisher
Vanneste D, Bai Q, Hasan S, Peng W, Pirottin D, Schyns J, et al. MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. Nat Immunol. 2023;24:827-840 pubmed publisher
Liang Z, Sun R, Tu P, Liang Y, Liang L, Liu F, et al. Immune-related gene-based prognostic index for predicting survival and immunotherapy outcomes in colorectal carcinoma. Front Immunol. 2022;13:944286 pubmed publisher
Wang L, Wang D, Sonzogni O, Ke S, Wang Q, Thavamani A, et al. PARP-inhibition reprograms macrophages toward an anti-tumor phenotype. Cell Rep. 2022;41:111462 pubmed publisher
Zhang Z, Li J, Zhang M, Li B, Pan X, Dong X, et al. GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes. Mol Nutr Food Res. 2022;66:e2200300 pubmed publisher
Kim N, Kim M, Woo S, Han I, Park J, Kim K, et al. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia. Nat Commun. 2022;13:5461 pubmed publisher
Xiong A, Zhang J, Chen Y, Zhang Y, Yang F. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM. EBioMedicine. 2022;83:104239 pubmed publisher
Muñoz M, Eren Cimenci C, Goel K, Comtois Bona M, Hossain M, McTiernan C, et al. Nanoengineered Sprayable Therapy for Treating Myocardial Infarction. ACS Nano. 2022;16:3522-3537 pubmed publisher
Palathingal Bava E, George J, Tarique M, Iyer S, Sahay P, Gomez Aguilar B, et al. Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models. JCI Insight. 2022;7: pubmed publisher
Tang P, Chung J, Xue V, Xiao J, Meng X, Huang X, et al. Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition. Adv Sci (Weinh). 2022;9:e2101235 pubmed publisher
Xiao M, Bian Q, Lao Y, Yi J, Sun X, Sun X, et al. SENP3 loss promotes M2 macrophage polarization and breast cancer progression. Mol Oncol. 2022;16:1026-1044 pubmed publisher
Zhang F, Fan L, Zhang H, Huang W, Sun D, Pan B, et al. Deficiency of IKKα in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury. J Immunol Res. 2021;2021:5521051 pubmed publisher
Tu W, Gong J, Zhou Z, Tian D, Wang Z. TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling. Cell Death Dis. 2021;12:882 pubmed publisher
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Chen G, Phan V, Luo X, Cao D. The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia. J Mol Cell Cardiol. 2021;159:62-79 pubmed publisher
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Jiang W, Wang J, Luo J, Chen Y, Pi J, Ma X, et al. Airway epithelial integrin β4-deficiency exacerbates lipopolysaccharide-induced acute lung injury. J Cell Physiol. 2021;236:7711-7724 pubmed publisher
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Li H, Wu G, Fang Q, Zhang M, Hui X, Sheng B, et al. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018;9:272 pubmed publisher
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product information
Antigen :
CD206
Apps. Abbrev. :
ICFC, FC, IHC-F
Cat # :
141710
Clone :
C068C2
Item :
Alexa Fluor® 488 anti-mouse CD206 (MMR)
Isotype :
Rat IgG2a, κ
Other Names :
MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Size :
100 μg
Price (USD) :
293 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
A488
Immunogen :
Recombinant mouse CD206 (MMR)
Application Notes :
Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)^4,5.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA