product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-mouse LAP (TGF-β1)
catalog :
141402
quantity :
100 μg
price :
194 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
TW7-16B4
reactivity :
human, mouse
application :
western blot, immunoprecipitation, flow cytometry
more info or order :
citations: 26
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 5:100; loading ...; fig 7g
Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, et al. Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. Nat Commun. 2021;12:4821 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3i
Amoozgar Z, Kloepper J, Ren J, Tay R, Kazer S, Kiner E, et al. Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nat Commun. 2021;12:2582 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Brownlie D, Doughty Shenton D, Yh Soong D, Nixon C, O Carragher N, M Carlin L, et al. Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3
Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
Prado C, Gaiazzi M, Gonzalez H, Ugalde V, Figueroa A, Osorio Barrios F, et al. Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:571 pubmed publisher
  • flow cytometry; mouse; fig 6
Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed publisher
  • flow cytometry; mouse
Clemente Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016;530:434-40 pubmed publisher
  • flow cytometry; mouse; fig 3a
Wei R, Hu Y, Dong F, Xu X, Hu A, Gao G. Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells. Immunol Cell Biol. 2016;94:388-99 pubmed publisher
  • flow cytometry; mouse
Johannesson B, Sattler S, Semenova E, Pastore S, Kennedy Lydon T, Sampson R, et al. Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice. Dis Model Mech. 2014;7:977-85 pubmed publisher
  • flow cytometry; mouse
Bedke T, Iannitti R, De Luca A, Giovannini G, Fallarino F, Berges C, et al. Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice. Immunol Cell Biol. 2014;92:659-70 pubmed publisher
Malenica I, Adam J, Corgnac S, Mezquita L, Auclin E, Damei I, et al. Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade. Nat Commun. 2021;12:5209 pubmed publisher
Draganov D, Han Z, Rana A, Bennett N, Irvine D, Lee P. Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer. NPJ Breast Cancer. 2021;7:22 pubmed publisher
Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, et al. Siah2 control of T-regulatory cells limits anti-tumor immunity. Nat Commun. 2020;11:99 pubmed publisher
Jiao S, Subudhi S, Aparicio A, Ge Z, Guan B, Miura Y, et al. Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy. Cell. 2019;179:1177-1190.e13 pubmed publisher
Widjaja A, Singh B, Adami E, Viswanathan S, Dong J, D Agostino G, et al. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. Gastroenterology. 2019;: pubmed publisher
Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang M, Fucile G, et al. Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity. Immunity. 2019;50:152-165.e8 pubmed publisher
Wang W, Marinis J, Beal A, Savadkar S, Wu Y, Khan M, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018;34:757-774.e7 pubmed publisher
Steenbrugge J, Breyne K, Demeyere K, De Wever O, Sanders N, van den Broeck W, et al. Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer. J Exp Clin Cancer Res. 2018;37:191 pubmed publisher
Nawaz A, Mehmood A, Kanatani Y, Kado T, Igarashi Y, Takikawa A, et al. Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. Sci Rep. 2018;8:11370 pubmed publisher
Rogers M, Lamens K, Shafagati N, Johnson M, Oury T, Joyce S, et al. CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol. 2018;201:1253-1266 pubmed publisher
Becker W, Nagarkatti M, Nagarkatti P. miR-466a Targeting of TGF-β2 Contributes to FoxP3+ Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation. Front Immunol. 2018;9:688 pubmed publisher
Mencarelli A, Vacca M, Khameneh H, Acerbi E, Tay A, Zolezzi F, et al. Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway. Front Immunol. 2018;9:261 pubmed publisher
Fang Q, Wang X, Zhao W, Ding S, Shi B, Xia Y, et al. Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-β1 pathways. Sci Rep. 2018;8:3332 pubmed publisher
Skuljec J, Chmielewski M, Happle C, Habener A, Busse M, Abken H, et al. Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma. Front Immunol. 2017;8:1125 pubmed publisher
Sultana M, Du A, Carow B, Angbjär C, Weidner J, Kanatani S, et al. Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection. Infect Immun. 2017;85: pubmed publisher
Kuhn C, Rezende R, M Hamdi H, da Cunha A, Weiner H. IL-6 Inhibits Upregulation of Membrane-Bound TGF-? 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance. J Immunol. 2017;198:1202-1209 pubmed publisher
product information
Antigen :
LAP
Apps. Abbrev. :
FC, IP, WB
Cat # :
141402
Clone :
TW7-16B4
Item :
Purified anti-mouse LAP (TGF-β1)
Isotype :
Mouse IgG1, κ
Other Names :
Latency Associated Peptide (LAP), Transforming growth factor-beta 1 (TGF-b1), TGFB1, DPD1, TGF-beta1
Size :
100 μg
Price (USD) :
194 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Mouse Tgfb1 -transduced P3U1 cells
Application Notes :
Clone TW7-16B4 has been reported to not cross-react with bovine LAP.^2 Several anti-LAP antibody clones have been compared and characterized for their LAP reactivity.^2 TW7-16B4 recognizes recombinant LAP, latent TGF-ß, and pro-TGF-ß.Additional reported applications (for relevant formats) include: Western blotting^1 and immunoprecipitation^1.
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA