product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-mouse/human Helios
catalog :
137222
quantity :
100 tests
price :
409 USD
clonality :
monoclonal
host :
hamsters
conjugate :
APC
clone name :
22F6
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 26
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:50; loading ...; fig 3i
Van De Velde L, Allen E, Crawford J, Wilson T, Guy C, Russier M, et al. Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells. Cancer Res. 2021;81:5047-5059 pubmed publisher
Liang Z, Zhang Z, Zhang Q, Dong X, Yang X, Zhang J, et al. The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. iScience. 2022;25:105233 pubmed publisher
Gupta R, Vanlieshout E, Manion K, Bonilla D, Kim M, Mu xf1 oz Grajales C, et al. Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies. Front Immunol. 2022;13:886442 pubmed publisher
Severance A, Kinder J, Xin L, Burg A, Shao T, Pham G, et al. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022;25:104400 pubmed publisher
Dai B, Hackney J, Ichikawa R, Nguyen A, Elstrott J, Orozco L, et al. Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease. Cell Rep Med. 2021;2:100381 pubmed publisher
Fan L, Qi Y, Qu S, Chen X, Li A, Hendi M, et al. B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling. Gut Microbes. 2021;13:1-17 pubmed publisher
Harsha Krovi S, Zhang J, Michaels Foster M, Brunetti T, Loh L, Scott Browne J, et al. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020;11:6238 pubmed publisher
Wirasinha R, Davies A, Srivastava M, Sheridan J, Sng X, Delmonte O, et al. Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility. J Exp Med. 2021;218: pubmed publisher
Hu X, Liu Y, Zhang X, Kong D, Kong J, Zhao D, et al. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer. Neoplasia. 2020;22:539-553 pubmed publisher
Hübner M, Moellhoff N, Effinger D, Hinske C, Hirschberger S, Wu T, et al. MicroRNA-93 acts as an "anti-inflammatory tumor suppressor" in glioblastoma. Neurooncol Adv. 2020;2:vdaa047 pubmed publisher
Yang Y, Istomine R, Alvarez F, Al Aubodah T, Shi X, Takano T, et al. Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. Cell Rep. 2020;30:1515-1529.e4 pubmed publisher
Yue X, Lio C, Samaniego Castruita D, Li X, Rao A. Loss of TET2 and TET3 in regulatory T cells unleashes effector function. Nat Commun. 2019;10:2011 pubmed publisher
Yang M, Liu Y, Mo B, Xue Y, Ye C, Jiang Y, et al. Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4+ Treg Cells in Patients with Rheumatoid Arthritis. Cell Physiol Biochem. 2019;52:1178-1192 pubmed publisher
Chen S, Fang L, Guo W, Zhou Y, Yu G, Li W, et al. Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells. Nat Commun. 2018;9:5298 pubmed publisher
Björkander S, Johansson M, Hell L, Lasaviciute G, Nilsson C, Holmlund U, et al. FOXP3(+) CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early-life gut colonization. J Allergy Clin Immunol. 2016;138:905-908.e4 pubmed publisher
Björkander S, Hell L, Johansson M, Forsberg M, Lasaviciute G, Roos S, et al. Staphylococcus aureus-derived factors induce IL-10, IFN-γ and IL-17A-expressing FOXP3+CD161+ T-helper cells in a partly monocyte-dependent manner. Sci Rep. 2016;6:22083 pubmed publisher
Chellappa S, Lieske N, Hagness M, Line P, Taskén K, Aandahl E. Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells. J Leukoc Biol. 2016;100:5-16 pubmed publisher
Singh K, Hjort M, Thorvaldson L, Sandler S. Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice. Sci Rep. 2015;5:7767 pubmed publisher
Verhagen J, Wraith D. Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3? Treg cells. J Immunol Methods. 2014;414:58-64 pubmed publisher
Liu Y, Tran D, Fatheree N, Marc Rhoads J. Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2014;307:G177-86 pubmed publisher
Bedke T, Iannitti R, De Luca A, Giovannini G, Fallarino F, Berges C, et al. Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice. Immunol Cell Biol. 2014;92:659-70 pubmed publisher
Blankenhaus B, Reitz M, Brenz Y, Eschbach M, Hartmann W, Haben I, et al. Foxp3? regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathog. 2014;10:e1003913 pubmed publisher
Angin M, Klarenbeek P, King M, Sharma S, Moodley E, Rezai A, et al. Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. PLoS ONE. 2014;9:e86920 pubmed publisher
Stone B, Rieck M, Rawlings C, Kas A, Shendure J, Jones H, et al. Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells. Clin Immunol. 2012;145:153-60 pubmed publisher
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
Thornton A, Korty P, Tran D, Wohlfert E, Murray P, Belkaid Y, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010;184:3433-41 pubmed publisher
product information
Antigen :
Helios
Apps. Abbrev. :
ICFC
Cat # :
137222
Clone :
22F6
Item :
APC anti-mouse/human Helios
Isotype :
Armenian Hamster IgG
Other Names :
IKZF2, IKAROS family zinc finger 2, ANF1A2, ZNF1A2, ZNFN1A2
Size :
100 tests
Price (USD) :
409 USD
Reactivity :
Mouse, Human
Clonality :
Monoclonal
Host :
Armenian Hamster
Conjugate/Tag/Label :
APC
Immunogen :
Helios peptide (aa 51-107)
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA