product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-mouse/human Helios
catalog :
137216
quantity :
100 tests
price :
420 USD
clonality :
monoclonal
host :
hamsters
conjugate :
PE
clone name :
22F6
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1a
Weingartner E, Courneya J, Keegan A, Golding A. A novel method for assaying human regulatory T cell direct suppression of B cell effector function. J Immunol Methods. 2017;441:1-7 pubmed publisher
  • flow cytometry; human
Ito S, Bollard C, Carlsten M, Melenhorst J, Biancotto A, Wang E, et al. Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers. Mol Ther. 2014;22:1388-1395 pubmed publisher
Takimoto Y, Chu P, Nakamoto N, Hagihara Y, Mikami Y, Miyamoto K, et al. Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis. iScience. 2023;26:106220 pubmed publisher
Kasuya T, Tanaka S, Tamura J, Etori K, Shoda J, Hattori K, et al. Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake. Sci Rep. 2023;13:1653 pubmed publisher
Sawanobori Y, Kitazawa Y, Ueta H, Matsuno K, Tokuda N. Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1+ dendritic cells, and epithelium-free areas containing Foxp3+ thymic regulatory T cells. Histochem Cell Biol. 2021;156:133-146 pubmed publisher
Delacher M, Simon M, Sanderink L, Hotz Wagenblatt A, Wuttke M, Schambeck K, et al. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity. 2021;54:702-720.e17 pubmed publisher
Alhosaini K, Ansari M, Nadeem A, Bakheet S, Attia S, Alhazzani K, et al. 5-Aminoisoquinolinone, a PARP-1 Inhibitor, Ameliorates Immune Abnormalities through Upregulation of Anti-Inflammatory and Downregulation of Inflammatory Parameters in T Cells of BTBR Mouse Model of Autism. Brain Sci. 2021;11: pubmed publisher
Goodwin M, Lee E, Lakshmanan U, Shipp S, Froessl L, Barzaghi F, et al. CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells. Sci Adv. 2020;6:eaaz0571 pubmed publisher
Dean J, Peters L, Fuhrman C, Seay H, Posgai A, Stimpson S, et al. Innate inflammation drives NK cell activation to impair Treg activity. J Autoimmun. 2020;108:102417 pubmed publisher
Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K. Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 2019;10:3878 pubmed publisher
Yang B, Wang K, Wan S, Liang Y, Yuan X, Dong Y, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27:3629-3645.e6 pubmed publisher
Nagai Y, Ji M, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019;10:174 pubmed publisher
Van Gool F, Nguyen M, Mumbach M, Satpathy A, Rosenthal W, Giacometti S, et al. A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. 2019;50:362-377.e6 pubmed publisher
Adel Patient K, Lezmi G, Castelli F, Blanc S, Bernard H, Soulaines P, et al. Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow's milk. Clin Transl Allergy. 2018;8:38 pubmed publisher
Kim Y, Kim K, Yoon J, Scott D, Shevach E. SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells. J Immunol. 2018;201:1671-1680 pubmed publisher
Baron C, Kester L, Klaus A, Boisset J, Thambyrajah R, Yvernogeau L, et al. Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta. Nat Commun. 2018;9:2517 pubmed publisher
Trotta E, Bessette P, Silveria S, Ely L, Jude K, Le D, et al. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018;24:1005-1014 pubmed publisher
Santoni de Sio F, Passerini L, Restelli S, Valente M, Pramov A, Maccari M, et al. Role of human forkhead box P3 in early thymic maturation and peripheral T-cell homeostasis. J Allergy Clin Immunol. 2018;142:1909-1921.e9 pubmed publisher
Yuan X, Yang B, Dong Y, Yamamura A, Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. elife. 2017;6: pubmed publisher
Grinberg Bleyer Y, Oh H, Desrichard A, Bhatt D, Caron R, Chan T, et al. NF-?B c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. 2017;170:1096-1108.e13 pubmed publisher
Ostadkarampour M, Müller M, Ockinger J, Kullberg S, Linden A, Eklund A, et al. Distinctive Regulatory T Cells and Altered Cytokine Profile Locally in the Airways of Young Smokers with Normal Lung Function. PLoS ONE. 2016;11:e0164751 pubmed publisher
Zeng Z, Li L, Chen Y, Wei H, Sun R, Tian Z. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med. 2016;213:1079-93 pubmed publisher
Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, et al. Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. J Immunol. 2015;195:2141-8 pubmed publisher
Redpath S, Van Der Werf N, MacDonald A, Maizels R, Taylor M. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun. 2015;83:3881-9 pubmed publisher
Maruyama T. TGF-β-induced IκB-ζ controls Foxp3 gene expression. Biochem Biophys Res Commun. 2015;464:586-9 pubmed publisher
Maruyama T, Kobayashi S, Ogasawara K, Yoshimura A, Chen W, Muta T. Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells. J Leukoc Biol. 2015;98:385-93 pubmed publisher
Fuhrman C, Yeh W, Seay H, Saikumar Lakshmi P, Chopra G, Zhang L, et al. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol. 2015;195:145-55 pubmed publisher
Verhagen J, Wraith D. Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3? Treg cells. J Immunol Methods. 2014;414:58-64 pubmed publisher
Liu Y, Tran D, Fatheree N, Marc Rhoads J. Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2014;307:G177-86 pubmed publisher
Bedke T, Iannitti R, De Luca A, Giovannini G, Fallarino F, Berges C, et al. Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice. Immunol Cell Biol. 2014;92:659-70 pubmed publisher
Angin M, Klarenbeek P, King M, Sharma S, Moodley E, Rezai A, et al. Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. PLoS ONE. 2014;9:e86920 pubmed publisher
Zeng Z, Kong X, Li F, Wei H, Sun R, Tian Z. IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier. J Immunol. 2013;191:4184-93 pubmed publisher
Paiva R, Lino A, Bergman M, Caramalho I, Sousa A, Zelenay S, et al. Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc Natl Acad Sci U S A. 2013;110:6494-9 pubmed publisher
Baine I, Basu S, Ames R, Sellers R, Macian F. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol. 2013;190:1008-16 pubmed publisher
Stone B, Rieck M, Rawlings C, Kas A, Shendure J, Jones H, et al. Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells. Clin Immunol. 2012;145:153-60 pubmed publisher
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
Hatam L, DeVoti J, Rosenthal D, Lam F, Abramson A, Steinberg B, et al. Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression. Clin Cancer Res. 2012;18:1925-35 pubmed publisher
Zhao J, Zhao J, Fett C, Trandem K, Fleming E, Perlman S. IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med. 2011;208:1571-7 pubmed publisher
McClymont S, Putnam A, Lee M, Esensten J, Liu W, Hulme M, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol. 2011;186:3918-26 pubmed publisher
Dehzad N, Bopp T, Reuter S, Klein M, Martin H, Ulges A, et al. Regulatory T cells more effectively suppress Th1-induced airway inflammation compared with Th2. J Immunol. 2011;186:2238-44 pubmed publisher
Verhagen J, Wraith D. Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells". J Immunol. 2010;185:7129; author reply 7130 pubmed publisher
Thornton A, Korty P, Tran D, Wohlfert E, Murray P, Belkaid Y, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010;184:3433-41 pubmed publisher
product information
Antigen :
Helios
Apps. Abbrev. :
ICFC
Cat # :
137216
Clone :
22F6
Item :
PE anti-mouse/human Helios
Isotype :
Armenian Hamster IgG
Other Names :
IKZF2, IKAROS family zinc finger 2, ANF1A2, ZNF1A2, ZNFN1A2
Size :
100 tests
Price (USD) :
420 USD
Reactivity :
Mouse, Human
Clonality :
Monoclonal
Host :
Armenian Hamster
Conjugate/Tag/Label :
PE
Immunogen :
Helios peptide (aa 51-107)
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA