Purified anti-mouse CD117 (c-kit) | BioLegend 135102 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-mouse CD117 (c-kit)

catalog :

135102

quantity :

500 μg

price :

253 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

ACK2

reactivity :

mouse

application :

flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

BioLegend product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 2a	Laffey K, Stiles R, Ludescher M, Davis T, Khwaja S, Bram R, et al. Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations. Proc Natl Acad Sci U S A. 2022;119:e2118529119 pubmed publisher
flow cytometry; mouse; 1:100; loading ...; fig s2a	Hyrenius Wittsten A, Pilheden M, Sturesson H, Hansson J, Walsh M, Song G, et al. De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nat Commun. 2018;9:1770 pubmed publisher
immunohistochemistry - frozen section; mouse; loading ...; fig s1c	HÃ©rault A, Binnewies M, Leong S, Calero Nieto F, Zhang S, Kang Y, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544:53-58 pubmed publisher
blocking or activating experiments; mouse; fig s2	Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes D, Tate T, et al. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016;34:738-45 pubmed publisher
flow cytometry; mouse; loading ...; fig 4a	Kurkewich J, Bikorimana E, Nguyen T, Klopfenstein N, Zhang H, Hallas W, et al. The mirn23a microRNA cluster antagonizes B cell development. J Leukoc Biol. 2016;100:665-677 pubmed
flow cytometry; mouse; 0.5 ug/10*7 cells	Gong Y, Huang L, Cheng W, Li X, Lu J, Lin L, et al. Roles of interleukin-9 in the growth and cholecystokinin-induced intracellular calcium signaling of cultured interstitial cells of Cajal. PLoS ONE. 2014;9:e95898 pubmed publisher
	Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, et al. Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils. Cell Rep. 2020;32:108164 pubmed publisher
	Lin R, Zhang Y, Pradhan K, Li L. TICAM2-related pathway mediates neutrophil exhaustion. Sci Rep. 2020;10:14397 pubmed publisher
	Mercer H, Snyder L, Doherty C, Fox B, Bzik D, Denkers E. Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity. PLoS Pathog. 2020;16:e1008572 pubmed publisher
	Nguyen G, Shaban L, Mack M, Swanson K, Bunnell S, Sykes D, et al. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. elife. 2020;9: pubmed publisher
	Shook B, Wasko R, Mano O, Rutenberg Schoenberg M, Rudolph M, Zirak B, et al. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell. 2020;26:880-895.e6 pubmed publisher
	Brown C, Gudjonson H, Pritykin Y, Deep D, Lavallée V, Mendoza A, et al. Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 2019;179:846-863.e24 pubmed publisher
	Jordan S, Tung N, Casanova Acebes M, Chang C, Cantoni C, Zhang D, et al. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 2019;178:1102-1114.e17 pubmed publisher
	Li Y, Zou W, Brestoff J, Rohatgi N, Wu X, Atkinson J, et al. Fat-Produced Adipsin Regulates Inflammatory Arthritis. Cell Rep. 2019;27:2809-2816.e3 pubmed publisher
	Fischer K, Yajjala V, Bansal S, Bauer C, Chen R, Sun K. Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection. J Immunol. 2019;202:2027-2034 pubmed publisher
	Reeves P, Abbaslou M, Kools F, Vutipongsatorn K, Tong X, Gavegano C, et al. Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice. Oncotarget. 2017;8:94040-94053 pubmed publisher

product information

Antigen :

CD117

Apps. Abbrev. :

Cat # :

135102

Clone :

ACK2

Item :

Purified anti-mouse CD117 (c-kit)

Isotype :

Rat IgG2b, κ

Other Names :

c-KIT, Stem Cell Factor Receptor (SCFR)

Size :

500 μg

Price (USD) :

253 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PURE

Immunogen :

Murine IL-3 dependent mast cells

Application Notes :

Injection of ACK2 in mice of NOD genetic background is not recommended as mice develop immediate anaphylaxis, resulting in animal death. Treatment is possible with co-injection of Benadryl.^3ACK2 has been reported to block c-Kit function. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 135103). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 135114) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).;

more info or order :

BioLegend product webpage