product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-mouse CD41
catalog :
133913
quantity :
25 μg
price :
102 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
MWReg30
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 39
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Kniewallner K, de Sousa D, Unger M, Mrowetz H, Aigner L. Platelets in Amyloidogenic Mice Are Activated and Invade the Brain. Front Neurosci. 2020;14:129 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 1f
  • immunohistochemistry; mouse; loading ...; fig 1e
Li H, Tang C, Zhu X, Zhang W, Abudupataer M, Ding S, et al. Histamine deficiency facilitates coronary microthrombosis after myocardial infarction by increasing neutrophil-platelet interactions. J Cell Mol Med. 2020;24:3504-3520 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Zhou J, Yang A, Wang Y, Chen F, Zhao Z, Davra V, et al. Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation. Cell Commun Signal. 2018;16:98 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 6b
Pagan J, Kitaoka M, Anthony R. Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease. Cell. 2018;172:564-577.e13 pubmed publisher
  • flow cytometry; mouse; fig 1
Cordeiro O, Chypre M, Brouard N, Rauber S, Alloush F, Romera Hernandez M, et al. Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL. PLoS ONE. 2016;11:e0151848 pubmed publisher
Tang Y, Zhang Z, Liu S, Yao Y, Pan T, Qi J, et al. Conditioning therapy with N-acetyl-L-cysteine, decitabine and modified BUCY regimen for myeloid malignancies patients prior to allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2023;98:881-889 pubmed publisher
de Sousa D, Benedetti A, Altendorfer B, Mrowetz H, Unger M, Schallmoser K, et al. Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice. Aging (Albany NY). 2023;15:630-649 pubmed publisher
Ramdas B, Yuen L, Palam L, Patel R, Pasupuleti S, Jideonwo V, et al. Inhibition of BTK and PI3Kδ impairs the development of human JMML stem and progenitor cells. Mol Ther. 2022;30:2505-2521 pubmed publisher
Schloss M, Hulsmans M, Rohde D, Lee I, Severe N, Foy B, et al. B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nat Immunol. 2022;23:605-618 pubmed publisher
Chen W, Wilson M, Wang Y, Bergmeier W, Lanza F, Li R. Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative. J Thromb Haemost. 2022;20:1451-1463 pubmed publisher
Nakamura T, Morodomi Y, Kanaji S, Okamura T, Nagafuji K, Kanaji T. Detection of anti-GPIbα autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination. Thromb Res. 2022;209:80-83 pubmed publisher
Tang C, Wang L, Sheng Y, Zheng Z, Xie Z, Wu F, et al. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. Theranostics. 2021;11:9791-9804 pubmed publisher
Lawson H, van de Lagemaat L, Barile M, Tavosanis A, Durko J, Villacreces A, et al. CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation. Stem Cell Reports. 2021;16:2784-2797 pubmed publisher
Yan R, Ge X, Pang N, Ye H, Yuan L, Cheng B, et al. Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression. Cell Death Dis. 2021;12:955 pubmed publisher
Krutá M, Sunshine M, Chua B, Fu Y, Chawla A, Dillingham C, et al. Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging. Cell Stem Cell. 2021;28:1950-1965.e6 pubmed publisher
Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, et al. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nat Commun. 2021;12:1826 pubmed publisher
Yeung A, Villacorta Martin C, Hon S, Rock J, Murphy G. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020;4:6204-6217 pubmed publisher
Kobayashi H, Takubo K. Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR Protoc. 2020;1:100078 pubmed publisher
La Salvia S, Musante L, Lannigan J, Gigliotti J, Le T, Erdbrügger U. T cell-derived extracellular vesicles are elevated in essential HTN. Am J Physiol Renal Physiol. 2020;319:F868-F875 pubmed publisher
Parker K, Migliorini D, Perkey E, Yost K, Bhaduri A, Bagga P, et al. Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Cell. 2020;183:126-142.e17 pubmed publisher
Crescente M, Armstrong P, Kirkby N, Edin M, Chan M, Lih F, et al. Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. FASEB J. 2020;34:10027-10040 pubmed publisher
Upadhaya S, Krichevsky O, Akhmetzyanova I, Sawai C, Fooksman D, Reizis B. Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche. Cell Stem Cell. 2020;27:336-345.e4 pubmed publisher
Han P, Hanlon D, Arshad N, Lee J, Tatsuno K, Robinson E, et al. Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes. Sci Adv. 2020;6:eaaz1580 pubmed publisher
de Laval B, Maurizio J, Kandalla P, Brisou G, Simonnet L, Huber C, et al. C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells. Cell Stem Cell. 2020;26:657-674.e8 pubmed publisher
Fukushima T, Tanaka Y, Hamey F, Chang C, Oki T, Asada S, et al. Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 2019;29:4144-4158.e7 pubmed publisher
Wuescher L, Nishat S, Worth R. Characterization of a transgenic mouse model of chronic conditional platelet depletion. Res Pract Thromb Haemost. 2019;3:704-712 pubmed publisher
Siddique S, Kubouchi K, Shinmichi Y, Sawada N, Sugiura R, Itoh Y, et al. PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes. Sci Rep. 2019;9:13977 pubmed publisher
Chen 陈温纯 W, Voos K, Josephson C, Li R. Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets. Arterioscler Thromb Vasc Biol. 2019;39:2028-2037 pubmed publisher
Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate Yoshida T, Watanuki S, et al. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Rep. 2019;28:145-158.e9 pubmed publisher
Radulović V, van der Garde M, Koide S, Sigurdsson V, Lang S, Kaneko S, et al. Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis. Cell Rep. 2019;27:2826-2836.e5 pubmed publisher
Sung P, Huang T, Hsieh S. Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nat Commun. 2019;10:2402 pubmed publisher
Da Q, Derry P, Lam F, Rumbaut R. Fluorescent labeling of endogenous platelets for intravital microscopy: Effects on platelet function. Microcirculation. 2018;25:e12457 pubmed publisher
Kleppe M, Koche R, Zou L, van Galen P, Hill C, Dong L, et al. Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms. Cancer Cell. 2018;33:29-43.e7 pubmed publisher
Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al. Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell. 2017;21:747-760.e7 pubmed publisher
Peraki I, Palis J, Mavrothalassitis G. The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis. Mol Cell Biol. 2017;37: pubmed publisher
Zhang Q, Dong T, Li P, Wu M. Noninvasive low-level laser therapy for thrombocytopenia. Sci Transl Med. 2016;8:349ra101 pubmed publisher
Wang W, Oh S, Koester M, Abramowicz S, Wang N, Tall A, et al. Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice. Circ Cardiovasc Genet. 2016;9:213-22 pubmed publisher
McCabe A, Zhang Y, Thai V, Jones M, Jordan M, MacNamara K. Macrophage-Lineage Cells Negatively Regulate the Hematopoietic Stem Cell Pool in Response to Interferon Gamma at Steady State and During Infection. Stem Cells. 2015;33:2294-305 pubmed publisher
Sullivan B, Wang R, Tawfik O, Luyendyk J. Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010;115:286-94 pubmed publisher
product information
Antigen :
CD41
Apps. Abbrev. :
FC
Cat # :
133913
Clone :
MWReg30
Item :
APC anti-mouse CD41
Isotype :
Rat IgG1, κ
Other Names :
Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
Size :
25 μg
Price (USD) :
102 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
APC
Immunogen :
Mouse platelets
Application Notes :
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.^4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA