product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-mouse CD41
catalog :
133901
quantity :
50 μg
price :
89 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MWReg30
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 53
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Lee Y, Kim T, Kim Y, Kim S, Lee S, Seo S, et al. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med. 2021;53:1319-1331 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b, s2
Pariser D, Hilt Z, Ture S, Blick Nitko S, Looney M, Cleary S, et al. Lung megakaryocytes are immune modulatory cells. J Clin Invest. 2021;131: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4d
Ray S, Chee L, Matson D, Palermo N, Bresnick E, Hewitt K. Sterile α-motif domain requirement for cellular signaling and survival. J Biol Chem. 2020;295:7113-7125 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c, 5b
Hayes M, Ward S, Crawford G, Seoane R, Jackson W, Kipling D, et al. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2l
Massa L pez D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, et al. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1a
Cunin P, Bouslama R, Machlus K, Martínez Bonet M, Lee P, Wactor A, et al. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5g
Oda A, Tezuka T, Ueno Y, Hosoda S, Amemiya Y, Notsu C, et al. Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1. Sci Rep. 2018;8:8308 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Mumau M, Vanderbeck A, Lynch E, Golec S, Emerson S, Punt J. Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1. J Immunol. 2018;200:1078-1087 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Harly C, Cam M, Kaye J, Bhandoola A. Development and differentiation of early innate lymphoid progenitors. J Exp Med. 2018;215:249-262 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Patenaude J, Perreault C. Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile. J Immunol. 2016;196:4760-70 pubmed publisher
  • immunohistochemistry; mouse; 2.5 ug/ml; fig 1
Li Y, Nishikawa T, Kaneda Y. Platelet-cytokine Complex Suppresses Tumour Growth by Exploiting Intratumoural Thrombin-dependent Platelet Aggregation. Sci Rep. 2016;6:25077 pubmed publisher
  • flow cytometry; mouse; fig 1
Cordeiro O, Chypre M, Brouard N, Rauber S, Alloush F, Romera Hernandez M, et al. Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL. PLoS ONE. 2016;11:e0151848 pubmed publisher
  • immunocytochemistry; mouse; fig 8
Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, et al. IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015;209:453-66 pubmed publisher
  • flow cytometry; mouse; fig 1b
Marks Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, et al. SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development. Mol Cell Biol. 2015;35:2165-72 pubmed publisher
  • flow cytometry; mouse; fig 1
Rao T, Marks Bluth J, Sullivan J, Gupta M, Chandrakanthan V, Fitch S, et al. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015;14:307-22 pubmed publisher
Kugler E, Madiwale S, Yong D, Thoms J, Birger Y, Sykes D, et al. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Nat Commun. 2023;14:5871 pubmed publisher
Mahamud M, Geng X, Chen L, Ahmed Z, Ho Y, Srinivasan R. GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner. Microcirculation. 2023;30:e12787 pubmed publisher
Roweth H, Malloy M, Goreczny G, Becker I, Guo Q, Mittendorf E, et al. Pro-inflammatory megakaryocyte gene expression in murine models of breast cancer. Sci Adv. 2022;8:eabo5224 pubmed publisher
Theilgaard M xf6 nch K, Pundhir S, Reckzeh K, Su J, Tapia M, Furtw xe4 ngler B, et al. Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard. Nat Commun. 2022;13:3595 pubmed publisher
Schloss M, Hulsmans M, Rohde D, Lee I, Severe N, Foy B, et al. B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nat Immunol. 2022;23:605-618 pubmed publisher
Orecchioni M, Meyer M, Hedrick C, Ley K. Flow Cytometry and Mass Cytometry for Measuring the Immune Cell Infiltrate in Atherosclerotic Arteries. Methods Mol Biol. 2022;2419:779-800 pubmed publisher
Valet C, Magnen M, Qiu L, Cleary S, Wang K, Ranucci S, et al. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022;132: pubmed publisher
Kanaji S, Morodomi Y, Weiler H, Zarpellon A, Montgomery R, Ruggeri Z, et al. The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse. Haematologica. 2022;107:2133-2143 pubmed publisher
Lefebvre M, Surette F, Anthony S, Vijay R, Jensen I, Pewe L, et al. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021;37:109956 pubmed publisher
Yeung A, Villacorta Martin C, Hon S, Rock J, Murphy G. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020;4:6204-6217 pubmed publisher
Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu T, Chung A, et al. Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Cell Rep. 2020;32:107881 pubmed publisher
Kanagasabapathy D, Blosser R, Maupin K, Hong J, Alvarez M, Ghosh J, et al. Megakaryocytes promote osteoclastogenesis in aging. Aging (Albany NY). 2020;12:15121-15133 pubmed publisher
Kopeikina E, Dukhinova M, Yung A, Veremeyko T, Kuznetsova I, Lau T, et al. Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress. Prog Neurobiol. 2020;188:101783 pubmed publisher
O Dea K, Tan Y, Shah S, V Patel B, C Tatham K, Wilson M, et al. Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation. J Extracell Vesicles. 2020;9:1706708 pubmed publisher
Wilkinson A, Ryan D, Kucinski I, Wang W, Yang J, Nestorowa S, et al. Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro. Exp Hematol. 2019;76:1-12.e5 pubmed publisher
Pijuan Sala B, Griffiths J, Guibentif C, Hiscock T, Jawaid W, Calero Nieto F, et al. A single-cell molecular map of mouse gastrulation and early organogenesis. Nature. 2019;566:490-495 pubmed publisher
Malara A, Gruppi C, Abbonante V, Cattaneo D, De Marco L, Massa M, et al. EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis. J Exp Med. 2019;216:587-604 pubmed publisher
Commerford C, Dieterich L, He Y, Hell T, Montoya Zegarra J, Noerrelykke S, et al. Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes. Cell Rep. 2018;25:3554-3563.e4 pubmed publisher
Nakagawa M, RATHINAM C. Constitutive Activation of the Canonical NF-κB Pathway Leads to Bone Marrow Failure and Induction of Erythroid Signature in Hematopoietic Stem Cells. Cell Rep. 2018;25:2094-2109.e4 pubmed publisher
Upadhaya S, Sawai C, Papalexi E, Rashidfarrokhi A, Jang G, Chattopadhyay P, et al. Kinetics of adult hematopoietic stem cell differentiation in vivo. J Exp Med. 2018;215:2815-2832 pubmed publisher
Plein A, Fantin A, Denti L, Pollard J, Ruhrberg C. Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018;562:223-228 pubmed publisher
Lagarrigue F, Gingras A, Paul D, Valadez A, Cuevas M, Sun H, et al. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018;2:2358-2368 pubmed publisher
Crawford G, Hayes M, Seoane R, Ward S, Dalessandri T, Lai C, et al. Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response. Nat Immunol. 2018;19:859-870 pubmed publisher
Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval J, et al. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018;9:1431 pubmed publisher
Wolach O, Sellar R, Martinod K, Cherpokova D, McConkey M, Chappell R, et al. Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci Transl Med. 2018;10: pubmed publisher
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher
Tusi B, Wolock S, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, et al. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature. 2018;555:54-60 pubmed publisher
Sereni L, Castiello M, Marangoni F, Anselmo A, Di Silvestre D, Motta S, et al. Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation. J Allergy Clin Immunol. 2018;142:1272-1284 pubmed publisher
Khoramian Tusi B, Socolovsky M. High-throughput single-cell fate potential assay of murine hematopoietic progenitors in vitro. Exp Hematol. 2018;60:21-29.e3 pubmed publisher
McGarvey A, Rybtsov S, Souilhol C, Tamagno S, Rice R, Hills D, et al. A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation. J Exp Med. 2017;214:3731-3751 pubmed publisher
Poulos M, Ramalingam P, Gutkin M, Llanos P, Gilleran K, Rabbany S, et al. Endothelial transplantation rejuvenates aged hematopoietic stem cell function. J Clin Invest. 2017;127:4163-4178 pubmed publisher
Lefrançais E, Ortiz Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah D, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017;544:105-109 pubmed publisher
Malara A, Fresia C, Di Buduo C, Soprano P, Moccia F, Balduini C, et al. The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes. J Biol Chem. 2017;292:3239-3251 pubmed publisher
Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, et al. Peptidylarginine deiminase 4 promotes age-related organ fibrosis. J Exp Med. 2017;214:439-458 pubmed publisher
Poulos M, Ramalingam P, Gutkin M, Kleppe M, Ginsberg M, Crowley M, et al. Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis. Nat Commun. 2016;7:13829 pubmed publisher
Scialdone A, Tanaka Y, Jawaid W, Moignard V, Wilson N, Macaulay I, et al. Resolving early mesoderm diversification through single-cell expression profiling. Nature. 2016;535:289-293 pubmed publisher
Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D. Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010;137:3941-52 pubmed publisher
Sullivan B, Wang R, Tawfik O, Luyendyk J. Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010;115:286-94 pubmed publisher
product information
Antigen :
CD41
Apps. Abbrev. :
FC, FA
Cat # :
133901
Clone :
MWReg30
Item :
Purified anti-mouse CD41
Isotype :
Rat IgG1, κ
Other Names :
Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
Size :
50 μg
Price (USD) :
89 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PURE
Immunogen :
Mouse platelets
Application Notes :
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.^4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA