product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-mouse Tim-4
catalog :
130002
quantity :
200 μg
price :
293 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
RMT4-54
reactivity :
mouse
application :
neutralization, flow cytometry, mass cytometry
more info or order :
citations: 17
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s10a
Félix I, Jokela H, Karhula J, Kotaja N, Savontaus E, Salmi M, et al. Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue. Front Immunol. 2021;12:719979 pubmed publisher
  • flow cytometry; mouse; fig 3c
Forman R, Logunova L, Smith H, Wemyss K, Mair I, Boon L, et al. Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. PLoS Pathog. 2021;17:e1009768 pubmed publisher
  • mass cytometry; mouse; loading ...; fig s3
Lagnado A, Leslie J, Ruchaud Sparagano M, Victorelli S, Hirsova P, Ogrodnik M, et al. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 2021;40:e106048 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig 3e
Mouhadeb O, Ben Shlomo S, Cohen K, Farkash I, Gruber S, Maharshak N, et al. Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function. Front Immunol. 2018;9:2623 pubmed publisher
  • flow cytometry; mouse; fig 2a
Shaw T, Houston S, Wemyss K, Bridgeman H, Barbera T, Zangerle Murray T, et al. Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression. J Exp Med. 2018;215:1507-1518 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5c
A Gonzalez N, Quintana J, Garcia Silva S, Mazariegos M, González de la Aleja A, Nicolás Ávila J, et al. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017;214:1281-1296 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1
Foks A, Engelbertsen D, Kuperwaser F, Alberts Grill N, Gonen A, Witztum J, et al. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016;36:456-65 pubmed publisher
Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, et al. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. J Exp Med. 2023;220: pubmed publisher
Daemen S, Gainullina A, Kalugotla G, He L, Chan M, Beals J, et al. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2021;34:108626 pubmed publisher
Dasgupta D, Nakao Y, Mauer A, Thompson J, Sehrawat T, Liao C, et al. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020;159:1487-1503.e17 pubmed publisher
Ipseiz N, Pickering R, Rosas M, Tyrrell V, Davies L, Orr S, et al. Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO J. 2020;39:e103454 pubmed publisher
Shin J, Kwon M, Hwang J, Lee S, Lee J, Kim H, et al. Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation. Cell Death Dis. 2020;11:301 pubmed publisher
O Dea K, Tan Y, Shah S, V Patel B, C Tatham K, Wilson M, et al. Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation. J Extracell Vesicles. 2020;9:1706708 pubmed publisher
Zhong C, Zheng M, Cui K, Martins A, Hu G, Li D, et al. Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells. Immunity. 2020;52:83-95.e4 pubmed publisher
Imperatore F, Maurizio J, Vargas Aguilar S, Busch C, Favret J, Kowenz Leutz E, et al. SIRT1 regulates macrophage self-renewal. EMBO J. 2017;36:2353-2372 pubmed publisher
Johnson B, Midura E, Prakash P, Rice T, Kunz N, Kalies K, et al. Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2554-2563 pubmed publisher
Khan T, Wong E, Soni C, Rahman Z. Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production. J Immunol. 2013;190:1433-46 pubmed publisher
product information
Antigen :
Tim-4
Apps. Abbrev. :
FC, FA, Block
Cat # :
130002
Clone :
RMT4-54
Item :
Purified anti-mouse Tim-4
Isotype :
Rat IgG2a, κ
Other Names :
T cell immunoglobulin and mucin domain containing protein-4
Size :
200 μg
Price (USD) :
293 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PURE
Immunogen :
Mouse TIM4-Ig fusion protein
Application Notes :
Additional reported applications (for the relevant formats of this clone) include: in vivo induction of auto-antibody production^1 and blockade of dendritic cell Tim-4^2.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA