product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC/Cyanine7 anti-mouse Ly-6C
catalog :
128026
quantity :
100 μg
price :
311 USD
clonality :
monoclonal
host :
rat
conjugate :
APC/Cy7
clone name :
HK1.4
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 56
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:1000; loading ...; fig s6g
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang C, et al. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat Commun. 2021;12:5321 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Gurley J, Gmyrek G, Hargis E, Bishop G, Carr D, Elliott M. The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation. Cells. 2021;10: pubmed publisher
  • flow cytometry; mouse; 1:200
Olson B, Zhu X, Norgard M, Diba P, Levasseur P, Buenafe A, et al. Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment. Brain Behav Immun. 2021;97:102-118 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig s6a
Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, et al. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Nat Commun. 2020;11:609 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s3b
Kuriakose J, Redecke V, Guy C, Zhou J, Wu R, Ippagunta S, et al. Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis. J Clin Invest. 2019;129:2251-2265 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Yu S, Pearson A, Lim R, Rodgers D, Li S, Parker H, et al. Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate. Mol Ther. 2016;24:2078-2089 pubmed publisher
  • flow cytometry; mouse; fig 2
Eichenfield D, Troutman T, Link V, Lam M, Cho H, Gosselin D, et al. Tissue damage drives co-localization of NF-?B, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. elife. 2016;5: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Herz J, Johnson K, McGavern D. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med. 2015;212:1153-69 pubmed publisher
  • flow cytometry; mouse; fig 3a
Stoilova B, Kowenz Leutz E, Scheller M, Leutz A. Lymphoid to myeloid cell trans-differentiation is determined by C/EBP? structure and post-translational modifications. PLoS ONE. 2013;8:e65169 pubmed publisher
Nicolas Boluda A, Vaquero J, Vimeux L, Guilbert T, Barrin S, Kantari Mimoun C, et al. Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment. elife. 2021;10: pubmed publisher
de Mingo Pulido Á, Hänggi K, Celias D, Gardner A, Li J, Batista Bittencourt B, et al. The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake. Immunity. 2021;54:1154-1167.e7 pubmed publisher
McFarland A, Yalin A, Wang S, Cortez V, Landsberger T, Sudan R, et al. Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation. Immunity. 2021;54:1320-1337.e4 pubmed publisher
Bambousková M, Potůčková L, Paulenda T, Kerndl M, Mogilenko D, Lizotte K, et al. Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell Rep. 2021;34:108756 pubmed publisher
Heyde A, Rohde D, McAlpine C, Zhang S, Hoyer F, Gerold J, et al. Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell. 2021;184:1348-1361.e22 pubmed publisher
Rodriguez Garcia A, Lynn R, Poussin M, Eiva M, Shaw L, O Connor R, et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun. 2021;12:877 pubmed publisher
Grauel A, Nguyen B, Ruddy D, Laszewski T, Schwartz S, Chang J, et al. TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts. Nat Commun. 2020;11:6315 pubmed publisher
Baker G, Muhlich J, Palaniappan S, Moore J, Davis S, Santagata S, et al. SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma. Cell Syst. 2020;11:272-285.e9 pubmed publisher
Neupane A, Willson M, Chojnacki A, Vargas E Silva Castanheira F, Morehouse C, Carestia A, et al. Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis. Cell. 2020;183:110-125.e11 pubmed publisher
Liu X, Boyer M, Holmgren A, Shin S. Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation. Cell Host Microbe. 2020;28:683-698.e6 pubmed publisher
Green D, Eyre H, Singh A, Taylor J, Chu J, Jeys L, et al. Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer. Oncogene. 2020;: pubmed publisher
Kwok I, Becht E, Xia Y, Ng M, Teh Y, Tan L, et al. Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Immunity. 2020;: pubmed publisher
Bellomo A, Mondor I, Spinelli L, Lagueyrie M, Stewart B, Brouilly N, et al. Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages. Immunity. 2020;53:127-142.e7 pubmed publisher
Chou Y, Lin C, Dzhagalov I, Chen N, Lin C, Lin C, et al. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Sci Rep. 2020;10:8422 pubmed publisher
Mohamed E, Sierra R, Trillo Tinoco J, Cao Y, Innamarato P, Payne K, et al. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020;52:668-682.e7 pubmed publisher
Wada N, Yamada H, Motoyama S, Saburi M, Sugimoto T, Kubota H, et al. Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11. Mol Metab. 2020;37:100988 pubmed publisher
de Laval B, Maurizio J, Kandalla P, Brisou G, Simonnet L, Huber C, et al. C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells. Cell Stem Cell. 2020;26:657-674.e8 pubmed publisher
Simões F, Cahill T, Kenyon A, Gavriouchkina D, Vieira J, Sun X, et al. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair. Nat Commun. 2020;11:600 pubmed publisher
Lynn G, Sedlik C, Baharom F, Zhu Y, Ramirez Valdez R, Coble V, et al. Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens. Nat Biotechnol. 2020;38:320-332 pubmed publisher
Buerfent B, Ajendra J, Stamminger W, Gondorf F, Hoerauf A, Hübner M. TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection. GMS Infect Dis. 2019;7:Doc04 pubmed publisher
Guérin M, Regnier F, Feuillet V, Vimeux L, Weiss J, Bismuth G, et al. TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors. Nat Commun. 2019;10:4131 pubmed publisher
Fujita K, Chakarov S, Kobayashi T, Sakamoto K, Voisin B, Duan K, et al. Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen. Proc Natl Acad Sci U S A. 2019;116:14714-14723 pubmed publisher
Chan Y, Teo T, Utt A, Tan J, Amrun S, Abu Bakar F, et al. Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Mol Med. 2019;11: pubmed publisher
Mossadegh Keller N, Sieweke M. Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry. Bio Protoc. 2019;9: pubmed publisher
Domingos Pereira S, Sathiyanadan K, La Rosa S, Polák L, Chevalier M, Martel P, et al. Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell-Mediated Tumor Regression in the MB49 Bladder Cancer Model. Cancer Immunol Res. 2019;: pubmed publisher
Dmitrieva Posocco O, Dzutsev A, Posocco D, Hou V, Yuan W, Thovarai V, et al. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019;50:166-180.e7 pubmed publisher
Lim H, Lim S, Tan C, Thiam C, Goh C, Carbajo D, et al. Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen. Immunity. 2018;49:326-341.e7 pubmed publisher
Luo J, Qian A, Oetjen L, Yu W, Yang P, Feng J, et al. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. Immunity. 2018;49:107-119.e4 pubmed publisher
Evrard M, Kwok I, Chong S, Teng K, Becht E, Chen J, et al. Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity. 2018;48:364-379.e8 pubmed publisher
de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo H, Krummel M, et al. TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer Cell. 2018;33:60-74.e6 pubmed publisher
Clemente Casares X, Hosseinzadeh S, Barbu I, Dick S, Macklin J, Wang Y, et al. A CD103+ Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis. Immunity. 2017;47:974-989.e8 pubmed publisher
Mildner A, Schönheit J, Giladi A, David E, Lara Astiaso D, Lorenzo Vivas E, et al. Genomic Characterization of Murine Monocytes Reveals C/EBP? Transcription Factor Dependence of Ly6C- Cells. Immunity. 2017;46:849-862.e7 pubmed publisher
Capuccini B, Lin J, Talavera López C, Khan S, Sodenkamp J, Spaccapelo R, et al. Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria. Sci Rep. 2016;6:39258 pubmed publisher
Lee L, Ji M, Sinha M, Dong M, Ren X, Wang Y, et al. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS ONE. 2016;11:e0167693 pubmed publisher
van de Garde M, Movita D, van der Heide M, Herschke F, De Jonghe S, Gama L, et al. Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection. PLoS ONE. 2016;11:e0166094 pubmed publisher
Ippagunta S, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, et al. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proc Natl Acad Sci U S A. 2016;113:E6162-E6171 pubmed
Maisel D, Birzele F, Voss E, Nopora A, Bader S, Friess T, et al. Targeting Tumor Cells with Anti-CD44 Antibody Triggers Macrophage-Mediated Immune Modulatory Effects in a Cancer Xenograft Model. PLoS ONE. 2016;11:e0159716 pubmed publisher
Shepardson K, Larson K, Morton R, Prigge J, Schmidt E, Huber V, et al. Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection. MBio. 2016;7: pubmed publisher
Yin S, Jian F, Chen Y, Chien S, Hsieh M, Hsiao P, et al. Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis. Nat Commun. 2016;7:11311 pubmed publisher
Lin T, Liang W, Hsiao P, M S P, Wei W, Lin H, et al. Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine. PLoS ONE. 2015;10:e0138335 pubmed publisher
Copenhaver A, Casson C, Nguyen H, Duda M, Shin S. IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis. Proc Natl Acad Sci U S A. 2015;112:7557-62 pubmed publisher
Watson N, Schneider K, Massa P. SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis. J Immunol. 2015;194:2796-809 pubmed publisher
Movita D, van de Garde M, Biesta P, Kreefft K, Haagmans B, Zuniga E, et al. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015;89:4809-17 pubmed publisher
Abdala Valencia H, Berdnikovs S, Soveg F, Cook Mills J. ?-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2014;307:L482-96 pubmed publisher
Parsons M, Li L, Wallace A, Lee M, Katz H, Fernandez J, et al. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014;192:1361-71 pubmed publisher
Zuber J, Radtke I, Pardee T, Zhao Z, Rappaport A, Luo W, et al. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 2009;23:877-89 pubmed publisher
product information
Antigen :
Ly-6C
Apps. Abbrev. :
FC
Cat # :
128026
Clone :
HK1.4
Item :
APC/Cyanine7 anti-mouse Ly-6C
Isotype :
Rat IgG2c, κ
Other Names :
Lymphocyte antigen 6 complex, locus C
Size :
100 μg
Price (USD) :
311 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
APC_CYANINE7
Immunogen :
L3 cloned CTL cells
Application Notes :
Clone HK1.4 does not block the binding of clone RB6-8C5^8.Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells^1-3 and immunohistochemistry of frozen sections^4.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA