product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Pacific Blue™ anti-mouse Ly-6C
catalog :
128014
quantity :
100 μg
price :
265 USD
clonality :
monoclonal
host :
rat
conjugate :
Pacific Blue
clone name :
HK1.4
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 40
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 5 ug/ml; loading ...; fig s3a, s3b
Wang J, Li P, Yu Y, Fu Y, Jiang H, Lu M, et al. Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity. Science. 2020;367: pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig 3g
Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, et al. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Nat Commun. 2020;11:609 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s6a
Jin C, Lagoudas G, Zhao C, Bullman S, Bhutkar A, Hu B, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019;176:998-1013.e16 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e1b
Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Meyer I, Goetzke C, Kespohl M, Sauter M, Heuser A, Eckstein V, et al. Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. Front Immunol. 2018;9:2303 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
Lau A, Chung H, Komada T, Platnich J, Sandall C, Choudhury S, et al. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. J Clin Invest. 2018;128:2894-2913 pubmed publisher
  • flow cytometry; mouse; fig s5
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran N, Aiolfi R, et al. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 2016;8:155-70 pubmed publisher
  • flow cytometry; mouse; fig 5
Morales D, Monte K, Sun L, Struckhoff J, Agapov E, Holtzman M, et al. Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. J Virol. 2015;89:337-49 pubmed publisher
Jenull S, Mair T, Tscherner M, Penninger P, Zwolanek F, Silao F, et al. The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. Cell Rep. 2021;36:109406 pubmed publisher
Lebratti T, Lim Y, Cofie A, Andhey P, Jiang X, Scott J, et al. A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection. elife. 2021;10: pubmed publisher
Daemen S, Gainullina A, Kalugotla G, He L, Chan M, Beals J, et al. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2021;34:108626 pubmed publisher
Winkler E, Shrihari S, Hykes B, Handley S, Andhey P, Huang Y, et al. The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis. Cell. 2020;182:901-918.e18 pubmed publisher
Mohamed E, Sierra R, Trillo Tinoco J, Cao Y, Innamarato P, Payne K, et al. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020;52:668-682.e7 pubmed publisher
Pham T, Brewer S, Thurston T, Massis L, Honeycutt J, Lugo K, et al. Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection. Cell Host Microbe. 2020;27:54-67.e5 pubmed publisher
Zhang R, Earnest J, Kim A, Winkler E, Desai P, Adams L, et al. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Cell Rep. 2019;28:2647-2658.e5 pubmed publisher
Li S, Lu X, Shao Q, Chen Z, Huang Q, Jiao Z, et al. Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype. Front Neurol. 2019;10:893 pubmed publisher
Liu C, Chikina M, Deshpande R, Menk A, Wang T, Tabib T, et al. Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ. Immunity. 2019;51:381-397.e6 pubmed publisher
Kusnadi A, Park S, Yuan R, Pannellini T, Giannopoulou E, Oliver D, et al. The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Immunity. 2019;51:241-257.e9 pubmed publisher
Bitschar K, Sauer B, Focken J, Dehmer H, Moos S, Konnerth M, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019;10:2730 pubmed publisher
Burgener S, Leborgne N, Snipas S, Salvesen G, Bird P, Benarafa C. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Rep. 2019;27:3646-3656.e5 pubmed publisher
Li J, Wada S, Weaver L, Biswas C, Behrens E, Arany Z. Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. JCI Insight. 2019;5: pubmed publisher
Mathur R, Alam M, Zhao X, Liao Y, Shen J, Morgan S, et al. Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. Mucosal Immunol. 2019;12:612-623 pubmed publisher
Salazar V, Jagger B, Mongkolsapaya J, Burgomaster K, Dejnirattisai W, Winkler E, et al. Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice. Cell Rep. 2019;26:1585-1597.e4 pubmed publisher
Cunha L, Yang M, Carter R, Guy C, Harris L, Crawford J, et al. LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance. Cell. 2018;175:429-441.e16 pubmed publisher
Trompette A, Gollwitzer E, Pattaroni C, Lopez Mejia I, Riva E, Pernot J, et al. Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism. Immunity. 2018;48:992-1005.e8 pubmed publisher
Chung L, Thiele Orberg E, Geis A, Chan J, Fu K, Destefano Shields C, et al. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018;23:203-214.e5 pubmed publisher
Graham J, Swarts J, Lund J. A Mouse Model of West Nile Virus Infection. Curr Protoc Mouse Biol. 2017;7:221-235 pubmed publisher
Maschmeyer P, Petkau G, Siracusa F, Zimmermann J, Zügel F, Kühl A, et al. Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J Autoimmun. 2018;89:41-52 pubmed publisher
Frieler R, Chung Y, Ahlers C, Gheordunescu G, Song J, Vigil T, et al. Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury. Exp Neurol. 2017;298:104-111 pubmed publisher
Nair S, Poddar S, Shimak R, Diamond M. Interferon Regulatory Factor 1 Protects against Chikungunya Virus-Induced Immunopathology by Restricting Infection in Muscle Cells. J Virol. 2017;91: pubmed publisher
Muchenditsi A, Yang H, Hamilton J, Koganti L, Housseau F, Aronov L, et al. Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017;313:G39-G49 pubmed publisher
Tan X, Fujiu K, Manabe I, Nishida J, Yamagishi R, Terashima Y, et al. Choroidal Neovascularization Is Inhibited in Splenic-Denervated or Splenectomized Mice with a Concomitant Decrease in Intraocular Macrophage. PLoS ONE. 2016;11:e0160985 pubmed publisher
Thiele Orberg E, Fan H, Tam A, Dejea C, Destefano Shields C, Wu S, et al. The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. Mucosal Immunol. 2017;10:421-433 pubmed publisher
Mooney J, Lokken K, Byndloss M, George M, Velazquez E, Faber F, et al. Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection. Sci Rep. 2015;5:14603 pubmed publisher
Watson N, Schneider K, Massa P. SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis. J Immunol. 2015;194:2796-809 pubmed publisher
Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim W, et al. Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS ONE. 2014;9:e98456 pubmed publisher
Spees A, Kingsbury D, Wangdi T, Xavier M, Tsolis R, BAUMLER A. Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitis. Infect Immun. 2014;82:1692-7 pubmed publisher
Gharib S, Johnston L, Huizar I, Birkland T, Hanson J, Wang Y, et al. MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol. 2014;95:9-18 pubmed publisher
Ho A, Prabhu N, Betts R, Ge M, Dai X, Hutchinson P, et al. Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells. J Immunol. 2011;187:6011-21 pubmed publisher
Zuber J, Radtke I, Pardee T, Zhao Z, Rappaport A, Luo W, et al. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 2009;23:877-89 pubmed publisher
product information
Antigen :
Ly-6C
Apps. Abbrev. :
FC
Cat # :
128014
Clone :
HK1.4
Item :
Pacific Blue™ anti-mouse Ly-6C
Isotype :
Rat IgG2c, κ
Other Names :
Lymphocyte antigen 6 complex, locus C
Size :
100 μg
Price (USD) :
265 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PB
Immunogen :
L3 cloned CTL cells
Application Notes :
Clone HK1.4 does not block the binding of clone RB6-8C5^8.Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells^1-3 and immunohistochemistry of frozen sections^4.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA