product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-mouse Ly-6C
catalog :
128007
quantity :
50 μg
price :
134 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
HK1.4
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 55
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2b
Seung H, Wröbel J, Wadle C, B xfc hler T, Chiang D, Rettkowski J, et al. P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction. Basic Res Cardiol. 2022;117:16 pubmed publisher
  • flow cytometry; mouse; fig 3a
Petermann M, Orfanos Z, Sellau J, Gharaibeh M, Lotter H, Fleischer B, et al. CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection. Front Immunol. 2021;12:670219 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6
Gurley J, Gmyrek G, McClellan M, Hargis E, Hauck S, Dozmorov M, et al. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020;61:19 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 2b
BURNS J, Cotleur B, Walther D, Bajrami B, Rubino S, Wei R, et al. Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, et al. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nat Commun. 2018;9:4845 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 5g
Koronyo Y, Salumbides B, Sheyn J, Pelissier L, Li S, Ljubimov V, et al. Therapeutic effects of glatiramer acetate and grafted CD115⁺ monocytes in a mouse model of Alzheimer's disease. Brain. 2015;138:2399-422 pubmed publisher
Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, et al. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022;11:e12185 pubmed publisher
Wu L, Xu Y, Zhao H, Zhou Y, Chen Y, Yang S, et al. FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape. Theranostics. 2022;12:842-858 pubmed publisher
Song X, Li N, Liu Y, Wang Z, Wang T, Tan S, et al. CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol. 2022;15:101306 pubmed publisher
Cai B, Liu Y, Chong Y, Zhang H, Matsunaga A, Fang X, et al. IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies. Mol Cancer. 2021;20:165 pubmed publisher
Jiang W, Li Y, Zhang S, Kong G, Li Z. Association between cellular immune response and spleen weight in mice with hepatocellular carcinoma. Oncol Lett. 2021;22:625 pubmed publisher
Melo Silva C, Alves Peixoto P, Heath N, Tang L, Montoya B, Knudson C, et al. Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells. PLoS Pathog. 2021;17:e1009593 pubmed publisher
Deerhake M, Danzaki K, Inoue M, Cardakli E, Nonaka T, Aggarwal N, et al. Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 2021;54:484-498.e8 pubmed publisher
Liu Z, Nailwal H, Rector J, Rahman M, Sam R, McFadden G, et al. A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. Immunity. 2021;54:247-258.e7 pubmed publisher
Wang Y, Wang P, Zhang Y, Xu J, Li Z, Li Z, et al. Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation. Immunity. 2020;53:1168-1181.e7 pubmed publisher
Guldner I, Wang Q, Yang L, Golomb S, Zhao Z, Lopez J, et al. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell. 2020;183:1234-1248.e25 pubmed publisher
Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020;53:658-671.e6 pubmed publisher
Gerwing M, Kocman V, Stölting M, Helfen A, Masthoff M, Roth J, et al. Tracking of Tumor Cell-Derived Extracellular Vesicles In Vivo Reveals a Specific Distribution Pattern with Consecutive Biological Effects on Target Sites of Metastasis. Mol Imaging Biol. 2020;22:1501-1510 pubmed publisher
Franklin D, Sharick J, Ericsson Gonzalez P, Sanchez V, Dean P, Opalenik S, et al. MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC. JCI Insight. 2020;5: pubmed publisher
Winchell C, Mishra B, Phuah J, Saqib M, Nelson S, Maiello P, et al. Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques. Front Immunol. 2020;11:891 pubmed publisher
Ireland L, Luckett T, Schmid M, Mielgo A. Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis. Front Immunol. 2020;11:297 pubmed publisher
Yurdagul A, Subramanian M, Wang X, Crown S, Ilkayeva O, Darville L, et al. Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Cell Metab. 2020;31:518-533.e10 pubmed publisher
Fu R, Guo H, Janga S, Choi M, Klinngam W, Edman M, et al. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model. Sci Rep. 2020;10:1455 pubmed publisher
Fachi J, Sécca C, Rodrigues P, Mato F, Di Luccia B, Felipe J, et al. Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. J Exp Med. 2020;217: pubmed publisher
Davis F, Schaller M, denDekker A, Joshi A, Kimball A, Evanoff H, et al. Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing. Arterioscler Thromb Vasc Biol. 2019;39:2353-2366 pubmed publisher
Zhou W, Yui M, Williams B, Yun J, Wold B, Cai L, et al. Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development. Cell Syst. 2019;9:321-337.e9 pubmed publisher
Nguyen C, Tartar D, Bagood M, So M, Nguyen A, Gallegos A, et al. Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice. Diabetes. 2019;68:1499-1507 pubmed publisher
Kitamura K, Isoda K, Akita K, Miyosawa K, Kadoguchi T, Shimada K, et al. Lack of IκBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice. Int J Cardiol Heart Vasc. 2019;23:100344 pubmed publisher
Chen S, Chen L, Lin D, Chen S, Tsao Y, Guo H, et al. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019;25:602-616.e7 pubmed publisher
Huai W, Liu X, Wang C, Zhang Y, Chen X, Chen X, et al. KAT8 selectively inhibits antiviral immunity by acetylating IRF3. J Exp Med. 2019;216:772-785 pubmed publisher
Farsakoglu Y, Palomino Segura M, Latino I, Zanaga S, Chatziandreou N, Pizzagalli D, et al. Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner. Cell Rep. 2019;26:2307-2315.e5 pubmed publisher
Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, et al. CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019;20:89-101 pubmed publisher
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
White J, Xiong S, Malvin N, Khoury Hanold W, Heuckeroth R, Stappenbeck T, et al. Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses. Cell. 2018;175:1198-1212.e12 pubmed publisher
Sun K, Cheung K, Au S, Yeung S, Yeung E. Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury. Front Physiol. 2018;9:999 pubmed publisher
Wang F, Song Z, Qu X, Li F, Zhang L, Li W, et al. M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stress. Carcinogenesis. 2018;39:889-899 pubmed publisher
Zhang Y, Wang F, Cui S, Qu X. Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice. Cancer Biol Ther. 2018;19:735-744 pubmed publisher
Guichard V, Bonilla N, Durand A, Audemard Verger A, Guilbert T, Martin B, et al. Calcium-mediated shaping of naive CD4 T-cell phenotype and function. elife. 2017;6: pubmed publisher
Yáñez A, Coetzee S, Olsson A, Muench D, Berman B, Hazelett D, et al. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. Immunity. 2017;47:890-902.e4 pubmed publisher
Jiang W, Li Y, Sun J, Li L, Li J, Zhang C, et al. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017;7:6501 pubmed publisher
Mishra B, Lovewell R, Olive A, Zhang G, Wang W, Eugenin E, et al. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017;2:17072 pubmed publisher
FRANCIS M, Groves A, Sun R, Cervelli J, Choi H, Laskin J, et al. Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure. Toxicol Sci. 2017;155:474-484 pubmed publisher
FRANCIS M, Sun R, Cervelli J, Choi H, Mandal M, Abramova E, et al. Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol Sci. 2017;155:182-195 pubmed publisher
Gousopoulos E, Proulx S, Scholl J, Uecker M, Detmar M. Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema. Am J Pathol. 2016;186:2193-2203 pubmed publisher
Denk F, Crow M, Didangelos A, Lopes D, McMahon S. Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain. Cell Rep. 2016;15:1771-81 pubmed publisher
Zuchtriegel G, Uhl B, Puhr Westerheide D, Pörnbacher M, Lauber K, Krombach F, et al. Platelets Guide Leukocytes to Their Sites of Extravasation. PLoS Biol. 2016;14:e1002459 pubmed publisher
Kar S, Colino J, Snapper C. Distinct Cellular Pathways for Induction of CD4+ T Cell-Dependent Antibody Responses to Antigen Expressed by Intact Bacteria Versus Isolated Soluble Antigen. J Immunol. 2016;196:4204-13 pubmed publisher
Watson N, Schneider K, Massa P. SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis. J Immunol. 2015;194:2796-809 pubmed publisher
Chen S, Wang L, Fan J, Ye C, Dominguez D, Zhang Y, et al. Host miR155 promotes tumor growth through a myeloid-derived suppressor cell-dependent mechanism. Cancer Res. 2015;75:519-31 pubmed publisher
Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, et al. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res. 2014;24:1050-66 pubmed publisher
Radovanovic I, Leung V, Iliescu A, Bongfen S, Mullick A, Langlais D, et al. Genetic control of susceptibility to Candida albicans in SM/J mice. J Immunol. 2014;193:1290-300 pubmed publisher
Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika A, et al. Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci. 2014;34:8175-85 pubmed publisher
Petersen B, Dolgachev V, Rasky A, Lukacs N. IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease. J Leukoc Biol. 2014;95:809-815 pubmed
Younos I, Donkor M, Hoke T, Dafferner A, Samson H, Westphal S, et al. Tumor- and organ-dependent infiltration by myeloid-derived suppressor cells. Int Immunopharmacol. 2011;11:816-26 pubmed publisher
Zuber J, Radtke I, Pardee T, Zhao Z, Rappaport A, Luo W, et al. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 2009;23:877-89 pubmed publisher
product information
Antigen :
Ly-6C
Apps. Abbrev. :
FC
Cat # :
128007
Clone :
HK1.4
Item :
PE anti-mouse Ly-6C
Isotype :
Rat IgG2c, κ
Other Names :
Lymphocyte antigen 6 complex, locus C
Size :
50 μg
Price (USD) :
134 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE
Immunogen :
L3 cloned CTL cells
Application Notes :
Clone HK1.4 does not block the binding of clone RB6-8C5^8.Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells^1-3 and immunohistochemistry of frozen sections^4.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA