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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC/Cyanine7 anti-mouse Ly-6G
catalog :
127623
quantity :
25 μg
price :
99 USD
clonality :
monoclonal
host :
rat
conjugate :
APC/Cy7
clone name :
1A8
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 83
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig 6e
Wolpaw A, Grossmann L, Dessau J, Dong M, Aaron B, Brafford P, et al. Epigenetic state determines inflammatory sensing in neuroblastoma. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Petermann M, Orfanos Z, Sellau J, Gharaibeh M, Lotter H, Fleischer B, et al. CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection. Front Immunol. 2021;12:670219 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 9e
Nakatani T, Tsujimoto K, Park J, Jo T, Kimura T, Hayama Y, et al. The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II. Nat Commun. 2021;12:3333 pubmed publisher
  • flow cytometry; mouse; 1:250; loading ...; fig s8a
Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020;11:6343 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig e7f
Yousef H, Czupalla C, Lee D, Chen M, Burke A, Zera K, et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat Med. 2019;25:988-1000 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Mildner A, Schönheit J, Giladi A, David E, Lara Astiaso D, Lorenzo Vivas E, et al. Genomic Characterization of Murine Monocytes Reveals C/EBP? Transcription Factor Dependence of Ly6C- Cells. Immunity. 2017;46:849-862.e7 pubmed publisher
  • flow cytometry; mouse; fig s5
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran N, Aiolfi R, et al. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 2016;8:155-70 pubmed publisher
Abdelfattah N, Kumar P, Wang C, Leu J, Flynn W, Gao R, et al. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022;13:767 pubmed publisher
Lee A, Scott M, Wimmers F, Arunachalam P, Luo W, Fox C, et al. A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice. Nat Commun. 2022;13:549 pubmed publisher
Volberding P, Xin G, Kasmani M, Khatun A, Brown A, Nguyen C, et al. Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection. Cell Rep. 2021;35:109160 pubmed publisher
Kaczanowska S, Beury D, Gopalan V, Tycko A, Qin H, Clements M, et al. Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis. Cell. 2021;184:2033-2052.e21 pubmed publisher
Kovacs S, Oh C, Aachoui Y, Miao E. Evaluating cytokine production by flow cytometry using brefeldin A in mice. STAR Protoc. 2021;2:100244 pubmed publisher
Evren E, Ringqvist E, Tripathi K, Sleiers N, Rives I, Alisjahbana A, et al. Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity. 2021;54:259-275.e7 pubmed publisher
Guendel F, Kofoed Branzk M, Gronke K, Tizian C, Witkowski M, Cheng H, et al. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity. 2020;53:1015-1032.e8 pubmed publisher
Tuttle K, Waugh K, Araya P, Minter R, Orlicky D, Ludwig M, et al. JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Rep. 2020;33:108407 pubmed publisher
Kalafati L, Kourtzelis I, Schulte Schrepping J, Li X, Hatzioannou A, Grinenko T, et al. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020;183:771-785.e12 pubmed publisher
Forte D, Garcia Fernandez M, Sanchez Aguilera A, Stavropoulou V, Fielding C, Martin Perez D, et al. Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab. 2020;32:829-843.e9 pubmed publisher
Neupane A, Willson M, Chojnacki A, Vargas E Silva Castanheira F, Morehouse C, Carestia A, et al. Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis. Cell. 2020;183:110-125.e11 pubmed publisher
Briukhovetska D, Ohm B, Mey F, Aliberti J, Kleingarn M, Huber Lang M, et al. C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection. Front Immunol. 2020;11:1397 pubmed publisher
Oguri Y, Shinoda K, Kim H, Alba D, Bolus W, Wang Q, et al. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020;: pubmed publisher
Kim E, Woodruff M, Grigoryan L, Maier B, Lee S, Mandal P, et al. Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway. elife. 2020;9: pubmed publisher
Yu X, Dai Y, Zhao Y, Qi S, Liu L, Lu L, et al. Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response. Nat Commun. 2020;11:1110 pubmed publisher
Qi S, Lu L, Zhou F, Chen Y, Xu M, Chen L, et al. Neutrophil infiltration and whole-cell vaccine elicited by N-dihydrogalactochitosan combined with NIR phototherapy to enhance antitumor immune response and T cell immune memory. Theranostics. 2020;10:1814-1832 pubmed publisher
Kovacs B, Tillmann J, Freund L, Nimmerjahn F, Sadik C, Bieber K, et al. Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita. Front Immunol. 2019;10:3012 pubmed publisher
Wang Y, Zaitsev K, Lu Q, Li S, Schaiff W, Kim K, et al. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020;5:272-281 pubmed publisher
Nowak W, Grendas L, Sanmarco L, Estecho I, Arena Á, Eberhardt N, et al. Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR. EBioMedicine. 2019;50:290-305 pubmed publisher
Koyama M, Mukhopadhyay P, Schuster I, Henden A, Hülsdünker J, Varelias A, et al. MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota. Immunity. 2019;51:885-898.e7 pubmed publisher
Zhang F, Parayath N, Ene C, Stephan S, Koehne A, Coon M, et al. Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers. Nat Commun. 2019;10:3974 pubmed publisher
Cai W, Wang J, Hu M, Chen X, Lu Z, Bellanti J, et al. All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. J Neuroinflammation. 2019;16:175 pubmed publisher
Woods P, Kimmig L, Meliton A, Sun K, Tian Y, O Leary E, et al. Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
Tomida S, Aizawa K, Nishida N, Aoki H, Imai Y, Nagai R, et al. Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. Sci Rep. 2019;9:10751 pubmed publisher
Ho Y, del Toro R, Rivera Torres J, Rak J, Korn C, García García A, et al. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. Cell Stem Cell. 2019;25:407-418.e6 pubmed publisher
Buechler M, Kim K, Onufer E, Williams J, Little C, Dominguez C, et al. A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. Immunity. 2019;: pubmed publisher
Burgener S, Leborgne N, Snipas S, Salvesen G, Bird P, Benarafa C. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Rep. 2019;27:3646-3656.e5 pubmed publisher
Kubli S, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, et al. Fcmr regulates mononuclear phagocyte control of anti-tumor immunity. Nat Commun. 2019;10:2678 pubmed publisher
Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, et al. IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells. Cell Rep. 2019;27:835-846.e5 pubmed publisher
Delás M, Jackson B, Kovacević T, Vangelisti S, Munera Maravilla E, Wild S, et al. lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation. Cell Rep. 2019;27:719-729.e6 pubmed publisher
Hastings A, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, et al. Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia. iScience. 2019;13:339-350 pubmed publisher
O Boyle C, Haley M, Lemarchand E, Smith C, Allan S, Konkel J, et al. Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice. Int J Stroke. 2020;15:175-187 pubmed publisher
Minutti C, Modak R, MacDonald F, Li F, Smyth D, Dorward D, et al. A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation. Immunity. 2019;50:645-654.e6 pubmed publisher
Yu X, Chen L, Liu J, Dai B, Xu G, Shen G, et al. Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis. Nat Commun. 2019;10:574 pubmed publisher
Dmitrieva Posocco O, Dzutsev A, Posocco D, Hou V, Yuan W, Thovarai V, et al. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019;50:166-180.e7 pubmed publisher
Buzzelli J, O Connor L, Scurr M, Chung Nien Chin S, Catubig A, Ng G, et al. Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations. Am J Physiol Gastrointest Liver Physiol. 2019;316:G251-G262 pubmed publisher
Van Winkle J, Robinson B, Peters A, Li L, Nouboussi R, Mack M, et al. Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells. Cell Host Microbe. 2018;24:665-676.e4 pubmed publisher
Cohen M, Giladi A, Gorki A, Solodkin D, Zada M, Hladik A, et al. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting. Cell. 2018;175:1031-1044.e18 pubmed publisher
Medler T, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth A, et al. Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. Cancer Cell. 2018;34:561-578.e6 pubmed publisher
Quatrini L, Wieduwild E, Escalière B, Filtjens J, Chasson L, Laprie C, et al. Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells. Nat Immunol. 2018;19:954-962 pubmed publisher
Saleh R, Lee M, Khiew S, Louis C, Fleetwood A, Achuthan A, et al. CSF-1 in Inflammatory and Arthritic Pain Development. J Immunol. 2018;201:2042-2053 pubmed publisher
Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, et al. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog. 2018;14:e1006955 pubmed publisher
Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, et al. VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia. J Cell Biol. 2018;217:1503-1519 pubmed publisher
Anderson M, Chaze T, Coic Y, Injarabian L, Jönsson F, Lombion N, et al. MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker. Cell Chem Biol. 2018;25:483-493.e9 pubmed publisher
Clemente Casares X, Hosseinzadeh S, Barbu I, Dick S, Macklin J, Wang Y, et al. A CD103+ Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis. Immunity. 2017;47:974-989.e8 pubmed publisher
Tran L, Allen C, Xiao R, Moore E, Davis R, Park S, et al. Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma. Cancer Immunol Res. 2017;5:1141-1151 pubmed publisher
Dodd R, Lee C, Overton T, Huang W, Eward W, Luo L, et al. NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response. Cancer Res. 2017;77:4486-4497 pubmed publisher
Galani I, Triantafyllia V, Eleminiadou E, Koltsida O, Stavropoulos A, Manioudaki M, et al. Interferon-? Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness. Immunity. 2017;46:875-890.e6 pubmed publisher
Wang X, Häring M, Rathjen T, Lockhart S, Sørensen D, Ussar S, et al. Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene. 2017;36:4987-4996 pubmed publisher
Lee M, McCubbin J, Christensen A, Poole D, Rajasekhar P, Lieu T, et al. G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease. J Immunol. 2017;198:3565-3575 pubmed publisher
Murphy M, Pattabiraman G, Manavalan T, Medvedev A. Deficiency in IRAK4 activity attenuates manifestations of murine Lupus. Eur J Immunol. 2017;47:880-891 pubmed publisher
Currier M, Sprague L, Rizvi T, Nartker B, Chen C, Wang P, et al. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation. Oncotarget. 2017;8:17412-17427 pubmed publisher
Jaitin D, Weiner A, Yofe I, Lara Astiaso D, Keren Shaul H, David E, et al. Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq. Cell. 2016;167:1883-1896.e15 pubmed publisher
Wilson R, Espinosa Díez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, et al. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016;7:13597 pubmed publisher
Qi S, Li H, Lu L, Qi Z, Liu L, Chen L, et al. Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy. elife. 2016;5: pubmed publisher
Sen D, Jones S, Oswald E, Pinkard H, Corbin K, Krummel M. Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung. PLoS ONE. 2016;11:e0165064 pubmed publisher
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Tan X, Fujiu K, Manabe I, Nishida J, Yamagishi R, Terashima Y, et al. Choroidal Neovascularization Is Inhibited in Splenic-Denervated or Splenectomized Mice with a Concomitant Decrease in Intraocular Macrophage. PLoS ONE. 2016;11:e0160985 pubmed publisher
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product information
Antigen :
Ly-6G
Apps. Abbrev. :
FC
Cat # :
127623
Clone :
1A8
Item :
APC/Cyanine7 anti-mouse Ly-6G
Isotype :
Rat IgG2a, κ
Other Names :
Lymphocyte antigen 6 complex, locus G
Size :
25 μg
Price (USD) :
99 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
APC_CYANINE7
Immunogen :
Ly-6G transfected EL-4J cell line.
Application Notes :
While 1A8 recognizes only Ly-6G, clone RB6-8C5 recognizes both Ly-6G and Ly-6C. Clone RB6-8C5 binds with high affinity to mouse Ly-6G molecules and to a lower extent to Ly-6C^15. Clone RB6-8C5 impairs the binding of anti-mouse Ly-6G clone 1A8^15. However, clone RB6-8C5 is able to stain in the presence of anti-mouse Ly-6C clone HK1.4^16.Additional reported applications (for the relevant formats) include: immunohistochemistry^9 of frozen sections^10 and paraffin-embedded sections^11, depletion^4, 12-14, and spatial biology (IBEX)^20,21. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies or highly sensitive assays (Cat. No. 127632, 127649, 127650, 127661 and 127662).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA