product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-mouse Podoplanin
catalog :
127401
quantity :
50 μg
price :
71 USD
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
nonconjugated
clone name :
8.1.1
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 47
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1b
Jasso G, Jaiswal A, Varma M, Laszewski T, Grauel A, Omar A, et al. Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. PLoS Biol. 2022;20:e3001532 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e, s1b
Hayakawa M, Sakata A, Hayakawa H, Matsumoto H, Hiramoto T, Kashiwakura Y, et al. Characterization and visualization of murine coagulation factor VIII-producing cells in vivo. Sci Rep. 2021;11:14824 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020;11:519 pubmed publisher
  • flow cytometry; mouse; fig 2a
James K, Cosway E, LUCAS B, White A, Parnell S, Carvalho Gaspar M, et al. Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration. J Exp Med. 2018;215:2984-2993 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1b
Oda A, Tezuka T, Ueno Y, Hosoda S, Amemiya Y, Notsu C, et al. Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1. Sci Rep. 2018;8:8308 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Thomson C, van de Pavert S, Stakenborg M, Labeeuw E, Matteoli G, Mowat A, et al. Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators. J Immunol. 2018;201:215-229 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s9d
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, et al. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017;546:158-161 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4
Altmeier S, Toska A, Sparber F, Teijeira A, Halin C, LeibundGut Landmann S. IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa. PLoS Pathog. 2016;12:e1005882 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig 1b
Riedel A, Shorthouse D, Haas L, Hall B, Shields J. Tumor-induced stromal reprogramming drives lymph node transformation. Nat Immunol. 2016;17:1118-27 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3e
Quantius J, Schmoldt C, Vazquez Armendariz A, Becker C, El Agha E, Wilhelm J, et al. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. PLoS Pathog. 2016;12:e1005544 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3b
  • flow cytometry; mouse; loading ...; fig 3b
Jordan Williams K, Ramanujam N, Farr A, Ruddell A. The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses. PLoS ONE. 2016;11:e0156079 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Patenaude J, Perreault C. Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile. J Immunol. 2016;196:4760-70 pubmed publisher
  • flow cytometry; mouse; fig S1
Peteranderl C, Morales Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty R, et al. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016;126:1566-80 pubmed publisher
  • flow cytometry; mouse
Sullivan B, Teijaro J, de la Torre J, Oldstone M. Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog. 2015;11:e1004588 pubmed publisher
  • flow cytometry; mouse; fig 1
LUCAS B, White A, Ulvmar M, Nibbs R, Sitnik K, Agace W, et al. CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. Eur J Immunol. 2015;45:574-83 pubmed publisher
  • flow cytometry; mouse
Peters A, Burkett P, Sobel R, Buckley C, Watson S, Bettelli E, et al. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2015;125:129-40 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Astarita J, Cremasco V, Fu J, Darnell M, Peck J, Nieves Bonilla J, et al. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol. 2015;16:75-84 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Denton A, Roberts E, Linterman M, Fearon D. Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proc Natl Acad Sci U S A. 2014;111:12139-44 pubmed publisher
L xfc tge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, et al. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol. 2023;24:1149-1160 pubmed publisher
Mahamud M, Geng X, Chen L, Ahmed Z, Ho Y, Srinivasan R. GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner. Microcirculation. 2023;30:e12787 pubmed publisher
Kwok T, Medovich S, Silva Junior I, Brown E, Haug J, Barrios M, et al. Age-Associated Changes to Lymph Node Fibroblastic Reticular Cells. Front Aging. 2022;3:838943 pubmed publisher
Mece O, Houbaert D, Sassano M, Durré T, Maes H, Schaaf M, et al. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis. Nat Commun. 2022;13:2760 pubmed publisher
Takeuchi Y, Ohara D, Watanabe H, Sakaguchi N, Sakaguchi S, Kondoh G, et al. Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis. Sci Rep. 2021;11:18679 pubmed publisher
Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
Rodriguez A, Peske J, Woods A, Leick K, Mauldin I, Meneveau M, et al. Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts. Cell Rep. 2021;36:109422 pubmed publisher
Le H, Hill M, Kollak I, Keck M, Schroeder V, Wirth J, et al. An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury. EMBO Rep. 2021;22:e52785 pubmed publisher
Munir H, Jones J, Janowitz T, Hoffmann M, Euler M, Martins C, et al. Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth. Nat Commun. 2021;12:683 pubmed publisher
Kajiwara K, Sawa Y, Fujita T, Tamaoki S. Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy. BMC Nephrol. 2021;22:3 pubmed publisher
Alexandre Y, Devi S, Park S, Mackay L, Heath W, Mueller S. Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection. Cell Rep. 2020;33:108567 pubmed publisher
Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
Hegde S, Krisnawan V, Herzog B, Zuo C, Breden M, Knolhoff B, et al. Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. Cancer Cell. 2020;37:289-307.e9 pubmed publisher
Donati Y, Blasković S, Ruchonnet M xe9 trailler I, Lascano Maillard J, Barazzone Argiroffo C. Simultaneous isolation of endothelial and alveolar epithelial type I and type II cells during mouse lung development in the absence of a transgenic reporter. Am J Physiol Lung Cell Mol Physiol. 2020;318:L619-L630 pubmed publisher
Blasković S, Donati Y, Zanetti F, Ruchonnet M xe9 trailler I, Lemeille S, Cremona T, et al. Gestation and lactation exposure to nicotine induces transient postnatal changes in lung alveolar development. Am J Physiol Lung Cell Mol Physiol. 2020;318:L606-L618 pubmed publisher
Mahamud M, Geng X, Ho Y, Cha B, Kim Y, Ma J, et al. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019;146: pubmed publisher
Tamburini B, Finlon J, Gillen A, Kriss M, Riemondy K, Fu R, et al. Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells. Front Immunol. 2019;10:1036 pubmed publisher
Cheng H, Onder L, Novković M, Soneson C, Lütge M, Pikor N, et al. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun. 2019;10:1739 pubmed publisher
Dubrot J, Durães F, Harlé G, Schlaeppi A, Brighouse D, Madelon N, et al. Absence of MHC-II expression by lymph node stromal cells results in autoimmunity. Life Sci Alliance. 2018;1:e201800164 pubmed publisher
Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, et al. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018;558:454-459 pubmed publisher
Kraft J, Treuting P, Ho R. Indocyanine green nanoparticles undergo selective lymphatic uptake, distribution and retention and enable detailed mapping of lymph vessels, nodes and abnormalities. J Drug Target. 2018;26:494-504 pubmed publisher
Emgård J, Kammoun H, García Cassani B, Chesne J, Parigi S, Jacob J, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 2018;48:120-132.e8 pubmed publisher
Molica F, Meens M, Dubrot J, Ehrlich A, Roth C, Morel S, et al. Pannexin1 links lymphatic function to lipid metabolism and atherosclerosis. Sci Rep. 2017;7:13706 pubmed publisher
Kida H, Takahashi T, Nakamura Y, Kinoshita T, Hara M, Okamoto M, et al. Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome. Sci Rep. 2017;7:12032 pubmed publisher
Gao J, Zhao L, Liu L, Yang Y, Guo B, Zhu B. Disrupted fibroblastic reticular cells and interleukin-7 expression in tumor draining lymph nodes. Oncol Lett. 2017;14:2954-2960 pubmed publisher
Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, et al. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun. 2017;493:437-443 pubmed publisher
Kretschmer S, Dethlefsen I, Hagner Benes S, Marsh L, Garn H, Konig P. Visualization of intrapulmonary lymph vessels in healthy and inflamed murine lung using CD90/Thy-1 as a marker. PLoS ONE. 2013;8:e55201 pubmed publisher
Reis V, Silva J, Souza G, Semedo P, Buscariollo B, Pereira R, et al. The polysaccharide fraction of Propionibacterium acnes modulates the development of experimental focal segmental glomerulosclerosis. Immunobiology. 2012;217:831-41 pubmed publisher
Algars A, Karikoski M, Yegutkin G, Stoitzner P, Niemela J, Salmi M, et al. Different role of CD73 in leukocyte trafficking via blood and lymph vessels. Blood. 2011;117:4387-93 pubmed publisher
product information
Antigen :
Podoplanin
Apps. Abbrev. :
FC, IHC-F, SB
Cat # :
127401
Clone :
8.1.1
Item :
Purified anti-mouse Podoplanin
Isotype :
Syrian Hamster IgG
Other Names :
T1a, gp38, stromal cell marker
Size :
50 μg
Price (USD) :
71 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Syrian Hamster
Conjugate/Tag/Label :
PURE
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemistry^6, and spatial biology (IBEX)^8,9.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA