product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Ultra-LEAF™ Purified anti-mouse IFNAR-1
catalog :
127321
quantity :
100 μg
price :
110 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MAR1-5A3
reactivity :
mouse
application :
western blot, ELISA, neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
citations: 23
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 5
Li F, Wang Y, Lin L, Wang J, Xiao H, Li J, et al. Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation. J Immunol Res. 2016;2016:3623898 pubmed publisher
  • blocking or activating experiments; mouse; fig 6c
Masroori N, Merindol N, Berthoux L. The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion. Retrovirology. 2016;13:19 pubmed publisher
  • blocking or activating experiments; mouse; fig 6b
Wu V, Smith A, You H, Nguyen T, Ferguson R, Taylor M, et al. Plasmacytoid dendritic cell-derived IFNα modulates Th17 differentiation during early Bordetella pertussis infection in mice. Mucosal Immunol. 2016;9:777-86 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Vlachou K, Mintzas K, Glymenaki M, Ioannou M, Papadaki G, Bertsias G, et al. Elimination of Granulocytic Myeloid-Derived Suppressor Cells in Lupus-Prone Mice Linked to Reactive Oxygen Species-Dependent Extracellular Trap Formation. Arthritis Rheumatol. 2016;68:449-61 pubmed publisher
Holay N, Kennedy B, Murphy J, Konda P, Giacomantonio M, Brauer Chapin T, et al. After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism. Front Immunol. 2022;13:1047661 pubmed publisher
Zhao X, Shao C. Immunostaining of tumor-infiltrating immune-cell-related markers and cytokines in the tumor fractional radiation model of host PD-L1-deficient mice. STAR Protoc. 2022;3:101859 pubmed publisher
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou H, et al. SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells. Front Immunol. 2022;13:904875 pubmed publisher
Zhao X, Hu S, Zeng L, Liu X, Song Y, Zhang Y, et al. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. iScience. 2022;25:104690 pubmed publisher
Kalafati L, Kourtzelis I, Schulte Schrepping J, Li X, Hatzioannou A, Grinenko T, et al. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020;183:771-785.e12 pubmed publisher
Burke T, Engström P, Chavez R, Fonbuena J, Vance R, Welch M. Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis. Nat Microbiol. 2020;5:688-696 pubmed publisher
Wang J, Hussain T, Zhang K, Liao Y, Yao J, Song Y, et al. Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection. BMC Infect Dis. 2019;19:1031 pubmed publisher
Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, et al. Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells. Cell Rep. 2019;29:162-175.e9 pubmed publisher
Schreiber L, Urbiola C, Das K, Spiesschaert B, Kimpel J, Heinemann F, et al. The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer. Br J Cancer. 2019;121:647-658 pubmed publisher
Liang Y, Tang H, Guo J, Qiu X, Yang Z, Ren Z, et al. Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance. Nat Commun. 2018;9:4586 pubmed publisher
Xiao W, Klement J, Lu C, Ibrahim M, Liu K. IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells. J Immunol. 2018;201:264-277 pubmed publisher
Maelfait J, Liverpool L, Bridgeman A, Ragan K, Upton J, Rehwinkel J. Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017;36:2529-2543 pubmed publisher
Oyler Yaniv J, Oyler Yaniv A, Shakiba M, Min N, Chen Y, Cheng S, et al. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. 2017;66:635-647.e7 pubmed publisher
Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, et al. C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E540-E549 pubmed publisher
Marshall H, Urban S, Welsh R. Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon. J Virol. 2011;85:5929-39 pubmed publisher
Swanson C, Wilson T, Strauch P, Colonna M, Pelanda R, Torres R. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010;207:1485-500 pubmed publisher
Kelly Scumpia K, Scumpia P, Delano M, Weinstein J, Cuenca A, Wynn J, et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010;207:319-26 pubmed publisher
Habjan M, Pichlmair A, Elliott R, Overby A, Glatter T, Gstaiger M, et al. NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol. 2009;83:4365-75 pubmed publisher
Miller J, Ma Y, Bian J, Sheehan K, Zachary J, Weis J, et al. A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol. 2008;181:8492-503 pubmed
product information
Antigen :
IFNAR-1
Apps. Abbrev. :
FC, IP, WB, ELISA, Block
Cat # :
127321
Clone :
MAR1-5A3
Item :
Ultra-LEAF™ Purified anti-mouse IFNAR-1
Isotype :
Mouse IgG1, κ
Other Names :
IFNAR1, IFN-αR1, IFN-α/β Receptor Subunit 1
Size :
100 μg
Price (USD) :
110 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
ULEAF
Immunogen :
Exogenously expressed murine IFNAR1 extracellular domain
Application Notes :
Additional reported applications (for the relevant formats) include: Western blotting^1,2, immunoprecipitation^1, ELISA^1, and blocking^8,9. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 127322) (Endotoxin <0.01 EU/µg).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA