LEAF™ Purified anti-mouse IFNAR-1 | BioLegend 127304 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

LEAF™ Purified anti-mouse IFNAR-1

catalog :

127304

quantity :

500 μg

price :

450 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MAR1-5A3

reactivity :

mouse

application :

western blot, ELISA, neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments

citations: 18

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 5	Li F, Wang Y, Lin L, Wang J, Xiao H, Li J, et al. Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation. J Immunol Res. 2016;2016:3623898 pubmed publisher
blocking or activating experiments; mouse; fig 6c	Masroori N, Merindol N, Berthoux L. The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion. Retrovirology. 2016;13:19 pubmed publisher
blocking or activating experiments; mouse; fig 6b	Wu V, Smith A, You H, Nguyen T, Ferguson R, Taylor M, et al. Plasmacytoid dendritic cell-derived IFNÎ± modulates Th17 differentiation during early Bordetella pertussis infection in mice. Mucosal Immunol. 2016;9:777-86 pubmed publisher
flow cytometry; mouse; loading ...; fig 6a	Vlachou K, Mintzas K, Glymenaki M, Ioannou M, Papadaki G, Bertsias G, et al. Elimination of Granulocytic Myeloid-Derived Suppressor Cells in Lupus-Prone Mice Linked to Reactive Oxygen Species-Dependent Extracellular Trap Formation. Arthritis Rheumatol. 2016;68:449-61 pubmed publisher
	Wang J, Hussain T, Zhang K, Liao Y, Yao J, Song Y, et al. Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection. BMC Infect Dis. 2019;19:1031 pubmed publisher
	Schreiber L, Urbiola C, Das K, Spiesschaert B, Kimpel J, Heinemann F, et al. The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer. Br J Cancer. 2019;121:647-658 pubmed publisher
	Liang Y, Tang H, Guo J, Qiu X, Yang Z, Ren Z, et al. Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance. Nat Commun. 2018;9:4586 pubmed publisher
	Cheng Y, Schorey J. Mycobacterium tuberculosis-induced IFN-β production requires cytosolic DNA and RNA sensing pathways. J Exp Med. 2018;215:2919-2935 pubmed publisher
	Xiao W, Klement J, Lu C, Ibrahim M, Liu K. IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells. J Immunol. 2018;201:264-277 pubmed publisher
	Takeda Y, Azuma M, Funami K, Shime H, Matsumoto M, Seya T. Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide. Front Immunol. 2018;9:496 pubmed publisher
	Maelfait J, Liverpool L, Bridgeman A, Ragan K, Upton J, Rehwinkel J. Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017;36:2529-2543 pubmed publisher
	Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, et al. C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E540-E549 pubmed publisher
	Prasad S, Starck S, Shastri N. Presentation of Cryptic Peptides by MHC Class I Is Enhanced by Inflammatory Stimuli. J Immunol. 2016;197:2981-2991 pubmed
	Marshall H, Urban S, Welsh R. Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon. J Virol. 2011;85:5929-39 pubmed publisher
	Swanson C, Wilson T, Strauch P, Colonna M, Pelanda R, Torres R. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010;207:1485-500 pubmed publisher
	Kelly Scumpia K, Scumpia P, Delano M, Weinstein J, Cuenca A, Wynn J, et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010;207:319-26 pubmed publisher
	Habjan M, Pichlmair A, Elliott R, Overby A, Glatter T, Gstaiger M, et al. NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol. 2009;83:4365-75 pubmed publisher
	Miller J, Ma Y, Bian J, Sheehan K, Zachary J, Weis J, et al. A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol. 2008;181:8492-503 pubmed

product information

Antigen :

IFNAR-1

Apps. Abbrev. :

Flow Cytometry, IP, Western Blotting, ELISA, Block

Cat # :

127304

Clone :

MAR1-5A3

Item :

LEAF™ Purified anti-mouse IFNAR-1

Isotype :

Mouse IgG1, κ

Other Names :

IFNAR1, IFN-αR1, IFN-α/β Receptor Subunit 1

Size :

500 μg

Price (USD) :

450 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

LEAF

Immunogen :

Exogenously expressed murine IFNAR1 extracellular domain

Application Notes :

Additional reported applications (for the relevant formats) include: Western blotting 1,2 , immunoprecipitation 1 , ELISA 1 , and blocking 8,9 . The LEAF™ purified antibody (Endotoxin 0.1 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 127304). For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 127322) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin 0.01 EU/µg).