product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-mouse/human Mac-2 (Galectin-3)
catalog :
125401
quantity :
50 μg
price :
72 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
M3/38
reactivity :
human, mouse, dogs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 52
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3b, 3d
Li N, Zhao S, Zhang Z, Zhu Y, Gliniak C, Vishvanath L, et al. Adiponectin preserves metabolic fitness during aging. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...
Zhao S, Li N, Zhu Y, Straub L, Zhang Z, Wang M, et al. Partial leptin deficiency confers resistance to diet-induced obesity in mice. Mol Metab. 2020;37:100995 pubmed publisher
  • western blot; mouse; fig 2
Cheng X, Boza Serrano A, Turesson M, Deierborg T, Ekblad E, Voss U. Galectin-3 causes enteric neuronal loss in mice after left sided permanent middle cerebral artery occlusion, a model of stroke. Sci Rep. 2016;6:32893 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s9
Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, et al. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016;19:995-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Punt S, Thijssen V, Vrolijk J, de Kroon C, Gorter A, Jordanova E. Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. PLoS ONE. 2015;10:e0129119 pubmed publisher
  • immunocytochemistry; dogs
Reales E, Bernabé Rubio M, Casares Arias J, Rentero C, Fernández Barrera J, Rangel L, et al. The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation. J Cell Sci. 2015;128:2261-70 pubmed publisher
Matsudaira T, Nakano S, Konishi Y, Kawamoto S, Uemura K, Kondo T, et al. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Commun Biol. 2023;6:665 pubmed publisher
Sakamoto S, Nagasaki A, Shrestha M, Shintani T, Watanabe A, Furusho H, et al. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation. Sci Rep. 2023;13:9350 pubmed publisher
Zheng B, He Y, Yin S, Zhu X, Zhao Q, Yang H, et al. Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury. Research (Wash D C). 2023;6:0135 pubmed publisher
Ayyar B, Ettayebi K, Salmen W, Karandikar U, Neill F, Tenge V, et al. CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. Nat Commun. 2023;14:1148 pubmed publisher
Kaya T, Mattugini N, Liu L, Ji H, Cantuti Castelvetri L, Wu J, et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022;25:1446-1457 pubmed publisher
Hagemann C, Legart C, M xf8 llerh xf8 j M, Madsen M, Hansen H, K xf8 nig M, et al. A liver secretome gene signature-based approach for determining circulating biomarkers of NAFLD severity. PLoS ONE. 2022;17:e0275901 pubmed publisher
Di Liberto G, Egervari K, Kreutzfeldt M, Sch xfc rch C, Hewer E, Wagner I, et al. Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV. Brain. 2022;145:2730-2741 pubmed publisher
Ribieras A, Ortiz Y, Li Y, Huerta C, Le N, Shao H, et al. E-Selectin/AAV2/2 Gene Therapy Alters Angiogenesis and Inflammatory Gene Profiles in Mouse Gangrene Model. Front Cardiovasc Med. 2022;9:929466 pubmed publisher
Lorenz G, Ribeiro A, von Rauchhaupt E, W xfc rf V, Schmaderer C, Cohen C, et al. GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus. J Innate Immun. 2022;14:673-689 pubmed publisher
Zhang M, Qi T, Yang L, Kolarich D, Heisterkamp N. Multi-Faceted Effects of ST6Gal1 Expression on Precursor B-Lineage Acute Lymphoblastic Leukemia. Front Oncol. 2022;12:828041 pubmed publisher
Chakraborty A, Mohammed N, Bernasconi A, Dimitroff C. Analysis of Galectin-Binding Receptors on B Cells. Methods Mol Biol. 2022;2442:565-580 pubmed publisher
M xf8 llerh xf8 j M, Veidal S, Thrane K, Or xf3 D, Overgaard A, Salinas C, et al. Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH. Clin Transl Sci. 2022;15:1167-1186 pubmed publisher
Heitel P, Faudone G, Helmst xe4 dter M, Schmidt J, Kaiser A, Tjaden A, et al. A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice. Commun Chem. 2020;3:174 pubmed publisher
Tarighat S, Fei F, Joo E, Abdel Azim H, Yang L, Geng H, et al. Overcoming Microenvironment-Mediated Chemoprotection through Stromal Galectin-3 Inhibition in Acute Lymphoblastic Leukemia. Int J Mol Sci. 2021;22: pubmed publisher
Gouna G, Klose C, Bosch Queralt M, Liu L, Gokce O, Schifferer M, et al. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021;218: pubmed publisher
Davison L, Alberto A, Dand H, Keller E, Patt M, Khan A, et al. S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development. Front Immunol. 2021;12:681503 pubmed publisher
Helmst xe4 dter M, Schmidt J, Kaiser A, Weizel L, Proschak E, Merk D. Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice. ACS Pharmacol Transl Sci. 2021;4:966-979 pubmed publisher
Perakakis N, Stefanakis K, Feigh M, Veidal S, Mantzoros C. Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis. Liver Int. 2021;41:1853-1866 pubmed publisher
Kannt A, Wohlfart P, Madsen A, Veidal S, Feigh M, Schmoll D. Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis. Br J Pharmacol. 2021;178:2412-2423 pubmed publisher
Bosch Queralt M, Cantuti Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, et al. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021;3:211-227 pubmed publisher
Safaiyan S, Besson Girard S, Kaya T, Cantuti Castelvetri L, Liu L, Ji H, et al. White matter aging drives microglial diversity. Neuron. 2021;109:1100-1117.e10 pubmed publisher
Manich G, Gómez López A, Almolda B, Villacampa N, Recasens M, Shrivastava K, et al. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Front Cell Neurosci. 2020;14:567404 pubmed publisher
Eakin A, Mc Erlain T, Burke A, Eaton A, Tipping N, Allocca G, et al. Circulating Levels of Epirubicin Cause Endothelial Senescence While Compromising Metabolic Activity and Vascular Function. Front Cell Dev Biol. 2020;8:799 pubmed publisher
Martinez L, Li X, Ramos Echazábal G, Faridi H, Zigmond Z, Santos Falcón N, et al. A Genetic Model of Constitutively Active Integrin CD11b/CD18. J Immunol. 2020;205:2545-2553 pubmed publisher
Perakakis N, Joshi A, Peradze N, Stefanakis K, Li G, Feigh M, et al. The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis. Hepatol Commun. 2020;4:1302-1315 pubmed publisher
Bj xf8 rnholm K, Skovsted G, Mitgaard Thomsen A, Rakipovski G, Tveden Nyborg P, Lykkesfeldt J, et al. Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis and affects genes involved in vascular remodelling and inflammation. Basic Clin Pharmacol Toxicol. 2021;128:103-114 pubmed publisher
Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher
Jia J, Bissa B, Brecht L, Allers L, Choi S, Gu Y, et al. AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020;77:951-969.e9 pubmed publisher
Jia J, Claude Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al. Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Dev Cell. 2019;: pubmed publisher
Boland M, Oró D, Tølbøl K, Thrane S, Nielsen J, Cohen T, et al. Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source. World J Gastroenterol. 2019;25:4904-4920 pubmed publisher
Roth J, Veidal S, Fensholdt L, Rigbolt K, Papazyan R, Nielsen J, et al. Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH. Sci Rep. 2019;9:9046 pubmed publisher
Bu D, Crewe C, Kusminski C, Gordillo R, Ghaben A, Kim M, et al. Human endotrophin as a driver of malignant tumor growth. JCI Insight. 2019;5: pubmed publisher
Bussi C, Peralta Ramos J, Arroyo D, Gallea J, Ronchi P, Kolovou A, et al. Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells. J Cell Sci. 2018;131: pubmed publisher
Crewe C, Joffin N, Rutkowski J, Kim M, Zhang F, Towler D, et al. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell. 2018;175:695-708.e13 pubmed publisher
Roth J, Feigh M, Veidal S, Fensholdt L, Rigbolt K, Hansen H, et al. INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis. World J Gastroenterol. 2018;24:195-210 pubmed publisher
Dou Z, Ghosh K, Vizioli M, Zhu J, Sen P, Wangensteen K, et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017;550:402-406 pubmed publisher
Seguin L, Camargo M, Wettersten H, Kato S, Desgrosellier J, von Schalscha T, et al. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov. 2017;7:1464-1479 pubmed publisher
Pigny F, Lassus A, Terrettaz J, Tranquart F, Corthesy B, Bioley G. Intranasal Vaccination With Salmonella-Derived Serodominant Secreted Effector Protein B Associated With Gas-Filled Microbubbles Partially Protects Against Gut Infection in Mice. J Infect Dis. 2016;214:438-46 pubmed publisher
Eich C, Lasonder E, Cruz L, Reinieren Beeren I, Cambi A, Figdor C, et al. Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. PLoS ONE. 2016;11:e0149637 pubmed publisher
Thiemann S, Man J, Chang M, Lee B, Baum L. Galectin-1 regulates tissue exit of specific dendritic cell populations. J Biol Chem. 2015;290:22662-77 pubmed publisher
Usategui A, Criado G, Izquierdo E, del Rey M, Carreira P, Ortiz P, et al. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis. 2013;72:2018-23 pubmed publisher
Chao C, Silverberg M, Martinez Maza O, Chi M, Abrams D, Haque R, et al. Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma. Clin Cancer Res. 2012;18:4702-12 pubmed
Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, et al. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. Am J Physiol Heart Circ Physiol. 2011;301:H1932-40 pubmed publisher
Jacob N, Guo S, Mathian A, Koss M, Gindea S, Putterman C, et al. B Cell and BAFF dependence of IFN-?-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice. J Immunol. 2011;186:4984-93 pubmed publisher
Evans C, Humphries J, Mattock K, Waltham M, Wadoodi A, Saha P, et al. Hypoxia and upregulation of hypoxia-inducible factor 1{alpha} stimulate venous thrombus recanalization. Arterioscler Thromb Vasc Biol. 2010;30:2443-51 pubmed publisher
Demotte N, Wieërs G, Van Der Smissen P, Moser M, Schmidt C, Thielemans K, et al. A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice. Cancer Res. 2010;70:7476-88 pubmed publisher
product information
Antigen :
Mac-2
Apps. Abbrev. :
FC, ICC, WB, IP, IHC, ELISA
Cat # :
125401
Clone :
M3/38
Item :
Purified anti-mouse/human Mac-2 (Galectin-3)
Isotype :
Rat IgG2a, κ
Other Names :
Galectin-3, Mac-2, Gal-3, RL-29, galactose-specific lectin 3, CBP-35, L-34, εBP
Size :
50 μg
Price (USD) :
72 USD
Reactivity :
Mouse, Human
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PURE
Immunogen :
Raised against galectin-3 of mouse origin
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of paraffin-embedded tissue sections^3-6, Western blotting^2, immunoprecipitation^1,2, immunofluorescence^7,8, and ELISA^9.;Clone M3/38 has been reported to recognize residues 48-100 in the amino-terminal domain of galectin-3^7.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA