product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-mouse CD197 (CCR7)
catalog :
120106
quantity :
200 μg
price :
426 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
4B12
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1a
Shi B, Geng J, Wang Y, Wei H, Walters B, Li W, et al. Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol. 2018;200:586-594 pubmed publisher
  • flow cytometry; mouse; fig 2
Hua J, Stevenson W, Dohlman T, Inomata T, Tahvildari M, Calcagno N, et al. Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis. Invest Ophthalmol Vis Sci. 2016;57:1457-67 pubmed publisher
Lutes L, Steier Z, McIntyre L, Pandey S, Kaminski J, Hoover A, et al. T cell self-reactivity during thymic development dictates the timing of positive selection. elife. 2021;10: pubmed publisher
Kuhn N, Lopez A, Li X, Cai W, Daniyan A, Brentjens R. CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function. Nat Commun. 2020;11:6171 pubmed publisher
Jin X, Zhang W, Wang Y, Liu J, Hao F, Li Y, et al. Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression. Cell Rep. 2020;31:107690 pubmed publisher
Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, et al. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020;52:542-556.e13 pubmed publisher
Galle Treger L, Hurrell B, Lewis G, Howard E, Jahani P, Banie H, et al. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. J Allergy Clin Immunol. 2020;145:502-517.e5 pubmed publisher
Chakraborty P, Vaena S, Thyagarajan K, Chatterjee S, Al Khami A, Selvam S, et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Rep. 2019;28:1879-1893.e7 pubmed publisher
Guenther C, Faisal I, Uotila L, Asens M, Harjunpää H, Savinko T, et al. A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation. Front Immunol. 2019;10:1138 pubmed publisher
Misumi I, Starmer J, Uchimura T, Beck M, Magnuson T, Whitmire J. Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection. Cell Rep. 2019;27:514-524.e5 pubmed publisher
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis. Immunity. 2019;50:600-615.e15 pubmed publisher
Zhao J, Wen X, Tian L, Li T, Xu C, Wen X, et al. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nat Commun. 2019;10:899 pubmed publisher
Martínez López M, Iborra S, Conde Garrosa R, Mastrangelo A, Danne C, Mann E, et al. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity. 2019;50:446-461.e9 pubmed publisher
Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, et al. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity. 2019;50:137-151.e6 pubmed publisher
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Espinosa J, Mou D, Adams B, Dibernardo L, MacDonald A, McRae M, et al. T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice. Front Immunol. 2018;9:1371 pubmed publisher
Lu Y, Wang Q, Xue G, Bi E, Ma X, Wang A, et al. Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors. Cancer Cell. 2018;33:1048-1060.e7 pubmed publisher
Shimba A, Cui G, Tani ichi S, Ogawa M, Abe S, Okazaki F, et al. Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018;48:286-298.e6 pubmed publisher
Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt M, Dhar P, Selvam S, et al. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018;27:85-100.e8 pubmed publisher
Wang H, Akuthota P, Kanaoka Y, Weller P. Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4. Allergy. 2017;72:927-936 pubmed publisher
Nagaoka M, Hatta Y, Kawaoka Y, Malherbe L. Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge. J Immunol. 2014;193:2812-20 pubmed publisher
Schilling B, Sondermann W, Zhao F, Griewank K, Livingstone E, Sucker A, et al. Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma. Ann Oncol. 2014;25:747-53 pubmed publisher
Benhamron S, Reiner I, Zcharia E, Atallah M, Grau A, Vlodavsky I, et al. Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice. PLoS ONE. 2012;7:e35602 pubmed publisher
Allie S, Zhang W, Fuse S, Usherwood E. Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol. 2011;186:6280-6 pubmed publisher
del Rio M, Cote Sierra J, Rodriguez Barbosa J. Flt3L-mobilized dendritic cells bearing H2-Kbm1 apoptotic cells do not induce cross-tolerance to CD8+ T cells across a class I MHC mismatched barrier. Transpl Int. 2011;24:501-13 pubmed publisher
Lim J, Kim J, Yoon I, Shin J, Nam H, Yang S, et al. Immunomodulation of delayed-type hypersensitivity responses by mesenchymal stem cells is associated with bystander T cell apoptosis in the draining lymph node. J Immunol. 2010;185:4022-9 pubmed publisher
Bankoti J, Burnett A, Navarro S, Miller A, Rase B, Shepherd D. Effects of TCDD on the fate of naive dendritic cells. Toxicol Sci. 2010;115:422-34 pubmed publisher
Flórido M, McColl S, Appelberg R. Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections. Immunobiology. 2009;214:643-52 pubmed publisher
Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
Allende M, Zhou D, Kalkofen D, BenHamed S, Tuymetova G, Borowski C, et al. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J. 2008;22:307-15 pubmed
Hwang I, Park C, Kehrl J. Impaired trafficking of Gnai2+/- and Gnai2-/- T lymphocytes: implications for T cell movement within lymph nodes. J Immunol. 2007;179:439-48 pubmed
Kurooka M, Kaneda Y. Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res. 2007;67:227-36 pubmed
Lee J, Kang S, Kim C. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues. J Immunol. 2007;178:301-11 pubmed
Mao A, Paharkova Vatchkova V, Hardy J, Miller M, Kovats S. Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells. J Immunol. 2005;175:5146-51 pubmed
Chen H, Hou J, Jiang X, Ma S, Meng M, Wang B, et al. Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals. J Immunol. 2005;175:591-8 pubmed
product information
Antigen :
CD197
Apps. Abbrev. :
Flow Cytometry
Cat # :
120106
Clone :
4B12
Item :
PE anti-mouse CD197 (CCR7)
Isotype :
Rat IgG2a, κ
Other Names :
C-C chemokine receptor type 7 (CCR7), MIP-3 beta receptor, EBV-induced G protein coupled receptor 1, EBI-1, CD197
Size :
200 μg
Price (USD) :
426 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE
Immunogen :
Mouse CCR7 transfected RBL-2H3 cells
Application Notes :
The 4B12 antibody does not inhibit binding of ligand to receptor. Additional reported applications (for the relevant formats) include: immunoprecipitation. To reduce non-specific binding to cells bearing Fc-receptors, pre-incubation of cells with anti-mouse CD16/CD32, clone 93 (Cat. No. 101301/101302) is recommended prior to immunofluorescent staining. Staining with clone 4B12 is recommended at 37°C (see supplemental data of PE staining at differing temperatures) .
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA