PE/Cyanine7 anti-mouse TLR4 (CD284)/MD2 Complex | BioLegend 117609 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Cyanine7 anti-mouse TLR4 (CD284)/MD2 Complex

catalog :

117609

quantity :

25 μg

price :

141 USD

clonality :

monoclonal

host :

rat

conjugate :

PE/Cy7

clone name :

MTS510

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; tbl s6	Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, et al. Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth. Nat Immunol. 2016;17:159-68 pubmed publisher
	Choconta J, Labi V, Dumbraveanu C, Kalpachidou T, Kummer K, Kress M. Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model. Immun Ageing. 2023;20:22 pubmed publisher
	Wang Y, Liu T, Shen C, Lin S, Hung C, Hsu L, et al. K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy. Cell Rep. 2022;38:110354 pubmed publisher
	Lee G, Gallo D, Alves de Souza R, Tiwari Heckler S, Csizmadia E, Harbison J, et al. Trauma-induced heme release increases susceptibility to bacterial infection. JCI Insight. 2021;6: pubmed publisher
	Zhang T, Zhang X, Lin C, Wu S, Wang F, Wang H, et al. Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood-brain barrier leakage in mice. J Neurochem. 2021;157:611-623 pubmed publisher
	Locke M, Francis R, Tsaousi E, Longstaff C. Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin. Sci Rep. 2020;10:11694 pubmed publisher
	Huggins M, Sjaastad F, Pierson M, Kucaba T, Swanson W, Staley C, et al. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Cell Rep. 2019;28:1729-1743.e5 pubmed publisher
	Chen Z, Amro E, Becker F, Holzer M, Rasa S, Njeru S, et al. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 2019;216:152-175 pubmed publisher
	Lancaster G, Langley K, Berglund N, Kammoun H, Reibe S, Estevez E, et al. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism. Cell Metab. 2018;27:1096-1110.e5 pubmed publisher
	Zanoni I, Tan Y, Di Gioia M, Springstead J, Kagan J. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity. 2017;47:697-709.e3 pubmed publisher
	Daringer N, Schwarz K, Leonard J. Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4. J Biol Chem. 2015;290:8764-77 pubmed publisher
	Yazji I, Sodhi C, Lee E, Good M, Egan C, Afrazi A, et al. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013;110:9451-6 pubmed publisher
	Tanigawa T, Morikawa A, Hayashi K, Dan K, Tsuchihashi N, Goto F, et al. Auditory cells produce nitric oxide in response to bacterial lipopolysaccharide. Innate Immun. 2013;19:115-20 pubmed publisher
	Laplante P, Amireault P, Subang R, Dieudé M, Levine J, Rauch J. Interaction of ?2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages. J Biol Chem. 2011;286:42494-503 pubmed publisher
	Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, et al. Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood. 2011;117:2211-22 pubmed publisher
	Nalbandian G, Paharkova Vatchkova V, Mao A, Nale S, Kovats S. The selective estrogen receptor modulators, tamoxifen and raloxifene, impair dendritic cell differentiation and activation. J Immunol. 2005;175:2666-75 pubmed

product information

Antigen :

TLR4 MD2 Complex

Apps. Abbrev. :

Cat # :

117609

Clone :

MTS510

Item :

PE/Cyanine7 anti-mouse TLR4 (CD284)/MD2 Complex

Isotype :

Rat IgG2a, κ

Other Names :

Toll-like Receptor 4/MD2 complex, TLR4-MD2-complex, TLR4/MD2, CD284/MD2

Size :

25 μg

Price (USD) :

141 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PE_CYANINE7

Immunogen :

Ba/F3 cell line transfected with mouse TLR4 /MD2 complex

Application Notes :

Anti-mouse TLR4 clones SA15-21 and MTS510 recognize distinct epitopes and don't cross block each other.^8 Clone MTS510 binds to an epitope of TLR4/MD-2 that is lost after LPS stimulation.^8 In addition to flow cytometric uses, the MTS510 antibody has also been used for immunoprecipitation, immunofluorescence, and blocking of LPS-induced stimulation. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 117607). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 117612) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).;

more info or order :

BioLegend product webpage