Ultra-LEAF™ Purified anti-mouse CD126 (IL-6Rα chain) | BioLegend 115815 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Ultra-LEAF™ Purified anti-mouse CD126 (IL-6Rα chain)

catalog :

115815

quantity :

100 μg

price :

182 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

D7715A7

reactivity :

mouse

application :

neutralization, immunoprecipitation, flow cytometry

more info or order :

BioLegend product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 5a	Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed publisher
	Viaud M, Abdel Wahab O, Gall J, Ivanov S, Guinamard R, Sore S, et al. ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms. Cell Rep. 2020;30:3397-3410.e5 pubmed publisher
	Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
	Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, et al. Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-?-Smad2 signaling in naïve helper T cells. Arthritis Res Ther. 2017;19:137 pubmed publisher

product information

Antigen :

CD126

Apps. Abbrev. :

FC, Block, IP, Neut

Cat # :

115815

Clone :

D7715A7

Item :

Ultra-LEAF™ Purified anti-mouse CD126 (IL-6Rα chain)

Isotype :

Rat IgG2b, κ

Other Names :

IL-6 Receptor α chain, IL-6R

Size :

100 μg

Price (USD) :

182 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

ULEAF

Immunogen :

OKT4 hybridoma cells

Application Notes :

Additional reported applications (for the relevant formats) include: immunoprecipitation^1,2,5, in vivo receptor blocking^1-2,4-6,8, and in vitro neutralization^7. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 115806) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 115804) or biotinylated anti-rat IgG second step (Cat. No. 405402), followed by SAv-PE (Cat. No. 405204)). The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 115808).Please note, this clone had previously reported reactivity to rat, however upon further testing it has been determined to not react with rat.;

more info or order :

BioLegend product webpage