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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-mouse CD45.2
catalog :
109832
quantity :
50 μg
price :
242 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV421
clone name :
104
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 51
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:600; loading ...; fig 5e
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 5a
LaFleur M, Nguyen T, Coxe M, Yates K, Trombley J, Weiss S, et al. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat Commun. 2019;10:1668 pubmed publisher
  • flow cytometry; mouse; 2:100; loading ...; fig 3c
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, et al. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proc Natl Acad Sci U S A. 2016;113:E8131-E8140 pubmed
Scherer S, Oberle S, Kanev K, Gerullis A, Wu M, de Almeida G, et al. Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development. Nat Immunol. 2023;24:501-515 pubmed publisher
Issa N, Bjeije H, Wilson E, Krishnan A, Dunuwille W, Parsons T, et al. KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress. Leukemia. 2023;37:728-740 pubmed publisher
Kemna J, Gout E, Daniau L, Lao J, Wei xdf ert K, Ammann S, et al. IFNγ binding to extracellular matrix prevents fatal systemic toxicity. Nat Immunol. 2023;24:414-422 pubmed publisher
Crooks S, Varga S, Harty J. Influenza-Induced CD103+ T Resident Memory Cells Exhibit Enhanced Functional Avidity over CD103- Memory T Cells in the Mediastinal Lymph Node. Immunohorizons. 2022;6:705-715 pubmed publisher
Zhang X, Li X, Wang Y, Chen Y, Hu Y, Guo C, et al. Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis. JCI Insight. 2022;7: pubmed publisher
Severance A, Kinder J, Xin L, Burg A, Shao T, Pham G, et al. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022;25:104400 pubmed publisher
Pulous F, Cruz Hern xe1 ndez J, Yang C, Kaya x, Paccalet A, Wojtkiewicz G, et al. Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis. Nat Neurosci. 2022;25:567-576 pubmed publisher
Corral D, Charton A, Krauss M, Blanquart E, Levillain F, Lefran xe7 ais E, et al. ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection. Cell Rep. 2022;39:110715 pubmed publisher
Martín Martín I, Valenzuela Leon P, Amo L, Shrivastava G, Iniguez E, Aryan A, et al. Aedes aegypti sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology. Cell Rep. 2022;39:110648 pubmed publisher
Song W, Antao O, Condiff E, Sanchez G, Chernova I, Zembrzuski K, et al. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity. 2022;55:290-307.e5 pubmed publisher
Koide S, Sigurdsson V, Radulović V, Saito K, Zheng Z, Lang S, et al. CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture. iScience. 2022;25:103603 pubmed publisher
Nazet U, Neubert P, Schatz V, Gr xe4 ssel S, Proff P, Jantsch J, et al. Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress. J Orofac Orthop. 2022;83:361-375 pubmed publisher
Liu Y, Debo B, Li M, Shi Z, Sheng W, Shi Y. LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade. Nat Commun. 2021;12:6831 pubmed publisher
Zebley C, Abdelsamed H, Ghoneim H, Alli S, Brown C, Haydar D, et al. Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation. Cell Rep. 2021;37:109796 pubmed publisher
Kim S, Srivatsan S, Chavez M, Shirai C, White B, Ahmed T, et al. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. Cell Rep. 2021;36:109626 pubmed publisher
Kawakami R, Kitagawa Y, Chen K, Arai M, Ohara D, Nakamura Y, et al. Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells. Immunity. 2021;54:947-961.e8 pubmed publisher
Nazet U, Feulner L, Muschter D, Neubert P, Schatz V, Grassel S, et al. Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint. Cells. 2021;10: pubmed publisher
Ringel A, Drijvers J, Baker G, Catozzi A, García Cañaveras J, Gassaway B, et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183:1848-1866.e26 pubmed publisher
Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, et al. Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils. Cell Rep. 2020;32:108164 pubmed publisher
Senatus L, López Díez R, Egaña Gorroño L, Liu J, Hu J, Daffu G, et al. RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism. JCI Insight. 2020;5: pubmed publisher
Iwanami N, Takeshita K, Lawir D, Suetake I, Tajima S, Sikora K, et al. Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience. 2020;23:101260 pubmed publisher
Kinder J, Turner L, Stelzer I, Miller Handley H, Burg A, Shao T, et al. CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization. Cell Rep. 2020;31:107784 pubmed publisher
Tribble J, Harder J, Williams P, John S. Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice. Mol Brain. 2020;13:81 pubmed publisher
Yu A, Zhao L, Eaton K, Ho S, Chen J, Poe S, et al. Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis. Cell Rep. 2020;31:107471 pubmed publisher
Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, et al. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020;52:542-556.e13 pubmed publisher
Rosenbaum S, Knecht M, Mollaee M, Zhong Z, Erkes D, McCue P, et al. FOXD3 Regulates VISTA Expression in Melanoma. Cell Rep. 2020;30:510-524.e6 pubmed publisher
Wilkinson A, Ishida R, Nakauchi H, Yamazaki S. Long-term ex vivo expansion of mouse hematopoietic stem cells. Nat Protoc. 2020;15:628-648 pubmed publisher
LaFleur M, Nguyen T, Coxe M, Miller B, Yates K, Gillis J, et al. PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity. Nat Immunol. 2019;20:1335-1347 pubmed publisher
Yang H, Graham L, Reagan A, Grabowska W, Schott W, Howell G. Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity. J Neuroinflammation. 2019;16:169 pubmed publisher
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed publisher
Chow M, Ozga A, Servis R, Frederick D, Lo J, Fisher D, et al. Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy. Immunity. 2019;: pubmed publisher
Yue X, Lio C, Samaniego Castruita D, Li X, Rao A. Loss of TET2 and TET3 in regulatory T cells unleashes effector function. Nat Commun. 2019;10:2011 pubmed publisher
Delás M, Jackson B, Kovacević T, Vangelisti S, Munera Maravilla E, Wild S, et al. lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation. Cell Rep. 2019;27:719-729.e6 pubmed publisher
Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, et al. Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Sci Rep. 2019;9:6136 pubmed publisher
Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, et al. Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell Rep. 2019;26:1854-1868.e5 pubmed publisher
Chopin M, Lun A, Zhan Y, Schreuder J, Coughlan H, D Amico A, et al. Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT. Immunity. 2019;50:77-90.e5 pubmed publisher
Garris C, Arlauckas S, Kohler R, Trefny M, Garren S, Piot C, et al. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1148-1161.e7 pubmed publisher
Van Braeckel Budimir N, Varga S, Badovinac V, Harty J. Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Rep. 2018;24:3374-3382.e3 pubmed publisher
Urata S, Kenyon E, Nayak D, Cubitt B, Kurosaki Y, Yasuda J, et al. BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. PLoS Pathog. 2018;14:e1007172 pubmed publisher
Sheng W, LaFleur M, Nguyen T, Chen S, Chakravarthy A, Conway J, et al. LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell. 2018;174:549-563.e19 pubmed publisher
Engblom C, Pfirschke C, Zilionis R, da Silva Martins J, Bos S, Courties G, et al. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017;358: pubmed publisher
Juttukonda L, Berends E, Zackular J, Moore J, Stier M, Zhang Y, et al. Dietary Manganese Promotes Staphylococcal Infection of the Heart. Cell Host Microbe. 2017;22:531-542.e8 pubmed publisher
Morawski P, Qi C, Bolland S. Non-pathogenic tissue-resident CD8+ T cells uniquely accumulate in the brains of lupus-prone mice. Sci Rep. 2017;7:40838 pubmed publisher
Wiesner D, Smith K, Kotov D, Nielsen J, Bohjanen P, Nielsen K. Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection. J Immunol. 2016;196:365-74 pubmed publisher
Allman W, Dey R, Liu L, Siddiqui S, Coleman A, Bhattacharya P, et al. TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection. Proc Natl Acad Sci U S A. 2015;112:E4094-103 pubmed publisher
Lemaitre F, Moreau H, Vedele L, Bousso P. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division. J Immunol. 2013;191:1578-85 pubmed publisher
Wen T, Besse J, Mingler M, Fulkerson P, Rothenberg M. Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. Proc Natl Acad Sci U S A. 2013;110:6067-72 pubmed publisher
Nakano Yokomizo T, Tahara Hanaoka S, Nakahashi Oda C, Nabekura T, Tchao N, Kadosaki M, et al. The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 2011;208:1661-71 pubmed publisher
product information
Antigen :
CD45.2
Apps. Abbrev. :
FC
Cat # :
109832
Clone :
104
Item :
Brilliant Violet 421™ anti-mouse CD45.2
Isotype :
Mouse (SJL) IgG2a, κ
Other Names :
Ly-5.2, LCA
Size :
50 μg
Price (USD) :
242 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV421
Immunogen :
B10.S mouse thymocytes and splenocytes
Application Notes :
The 104 antibody does not react with mouse cells expressing the CD45.1 alloantigen. Additional reported applications (for the relevant formats) include: immunoprecipitation^4, in vivo and in vitro blocking of B cell responses^1,2, and immunohistochemical staining of acetone-fixed frozen sections^3.
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA