product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Dazzle™ 594 anti-mouse CD49b (pan-NK cells)
catalog :
108924
quantity :
100 μg
price :
297 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
DX5
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 23
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2b, 4c
Seung H, Wröbel J, Wadle C, B xfc hler T, Chiang D, Rettkowski J, et al. P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction. Basic Res Cardiol. 2022;117:16 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 5e
Van De Velde L, Allen E, Crawford J, Wilson T, Guy C, Russier M, et al. Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells. Cancer Res. 2021;81:5047-5059 pubmed publisher
  • flow cytometry; mouse
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; mouse
Chu A, Kok S, TSUI J, Lin M, Aguirre B, Wadehra M. Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface. J Reprod Immunol. 2021;145:103309 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Qualai J, Li L, Cantero J, Tarrats A, Fernández M, Sumoy L, et al. Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. PLoS ONE. 2016;11:e0154253 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Brenndörfer E, Brass A, Karthe J, Ahlen G, Bode J, Sallberg M. Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy. J Immunol. 2014;192:1671-80 pubmed publisher
Miller P, Akama Garren E, Owen R, Demetriou C, Carroll T, Slee E, et al. p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer. Cell Death Differ. 2023;30:1619-1635 pubmed publisher
Rocca Y, Voissi xe8 re A, Valladeau Guilemond J, Bendriss Vermare N. Isolation and Identification of Dendritic Cell Subsets from Human and Mouse Tumors. Methods Mol Biol. 2023;2618:187-197 pubmed publisher
Mir xf3 L, L xf3 pez J, Guerrero P, Mart xed nez Bosch N, Manero Rup xe9 rez N, Moreno M, et al. Sialyltransferase Inhibitor Ac53FaxNeu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice. Cancers (Basel). 2022;14: pubmed publisher
de Mingo Pulido Á, Hänggi K, Celias D, Gardner A, Li J, Batista Bittencourt B, et al. The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake. Immunity. 2021;54:1154-1167.e7 pubmed publisher
Sanchez A, Orizaola M, Rodríguez Muñoz D, Aranda A, Castrillo A, Alemany S. Stress erythropoiesis in atherogenic mice. Sci Rep. 2020;10:18469 pubmed publisher
Chen D, Barsoumian H, Yang L, Younes A, Verma V, Hu Y, et al. SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD-1-Resistant Model of Non-Small Cell Lung Cancer. Cancer Immunol Res. 2020;8:883-894 pubmed publisher
Aldon Y, Kratochvil S, Shattock R, McKay P. Chemokine-Adjuvanted Plasmid DNA Induces Homing of Antigen-Specific and Non-Antigen-Specific B and T Cells to the Intestinal and Genital Mucosae. J Immunol. 2020;204:903-913 pubmed publisher
de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo H, Krummel M, et al. TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer Cell. 2018;33:60-74.e6 pubmed publisher
Huang H, Rajanbabu V, Pan C, Chan Y, Wu C, Chen J. A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors. Biomaterials. 2013;34:10151-9 pubmed publisher
Honjo K, Kubagawa Y, Jones D, DIZON B, Zhu Z, Ohno H, et al. Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (Fc?R). Proc Natl Acad Sci U S A. 2012;109:15882-7 pubmed
Younos I, Dafferner A, Gulen D, Britton H, Talmadge J. Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking. Int Immunopharmacol. 2012;13:245-56 pubmed publisher
Seyoum B, Yano M, Pirofski L. The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response. Vaccine. 2011;29:8002-11 pubmed publisher
Kim H, Lee M, Park A, Park E, Kim D, Ahn J, et al. Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice. Nephrology (Carlton). 2011;16:545-51 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
Qiu Q, Ravens I, Seth S, Rathinasamy A, Maier M, Davalos Misslitz A, et al. CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus. J Immunol. 2010;184:1681-9 pubmed publisher
Oertelt S, Lian Z, Cheng C, Chuang Y, Padgett K, He X, et al. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol. 2006;177:1655-60 pubmed
product information
Antigen :
CD49b
Apps. Abbrev. :
FC
Cat # :
108924
Clone :
DX5
Item :
PE/Dazzle™ 594 anti-mouse CD49b (pan-NK cells)
Isotype :
Rat IgM, κ
Other Names :
α2 integrin, VLA-2 α chain, DX5, Integrin α2 chain, ITGA2
Size :
100 μg
Price (USD) :
297 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_DZL594
Immunogen :
IL-2-propagated NK1.1 + cells from C57BL/6 mice
Application Notes :
The DX5 clone detects cells expressing relatively high levels of CD49b and may not be useful for the detection of cells expressing low levels of CD49b. DX5 does not block NK cell killing or binding to collagen in vitro. Additional reported applications (for the relevant formats) include: complement-mediated cytotoxicity^2 and immunohistochemical staining^5 of formalin-fixed and paraffin-embedded tissue sections as well as immunohistochemical staining of acetone-fixed frozen sections^10. The binding of DX5 antibody to splenic NK cells can be blocked by HMa2 antibody.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA