product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-mouse CD49b (pan-NK cells)
catalog :
108922
quantity :
100 μg
price :
248 USD
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
DX5
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3i
Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, et al. Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Sci Rep. 2019;9:6136 pubmed publisher
Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner J, et al. JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction. Cell Rep. 2022;38:110420 pubmed publisher
Prosser A, Huang W, Liu L, Dart S, Watson M, De Boer B, et al. Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation. Cell Rep. 2021;35:109141 pubmed publisher
McFarland A, Yalin A, Wang S, Cortez V, Landsberger T, Sudan R, et al. Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation. Immunity. 2021;54:1320-1337.e4 pubmed publisher
Utz B, Turpin R, Lampe J, Pouwels J, Klefstrom J. Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis. Sci Rep. 2020;10:18733 pubmed publisher
Liang J, Wang H, Ding W, Huang J, Zhou X, Wang H, et al. Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity. Sci Adv. 2020;6:eabc3646 pubmed publisher
Pessoa Rodrigues C, Herman J, Herquel B, Valsecchi C, Stehle T, Grün D, et al. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Sci Adv. 2020;6:eaaz4815 pubmed publisher
Gniadek T, Augustin L, Schottel J, Leonard A, Saltzman D, Greeno E, et al. A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers. J Immunother. 2020;43:217-221 pubmed publisher
Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, et al. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020;37:324-339.e8 pubmed publisher
Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019;29:787-803 pubmed publisher
Liu D, Yin X, Olyha S, Nascimento M, Chen P, White T, et al. IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity. 2019;: pubmed publisher
Cianciaruso C, Beltraminelli T, Duval F, Nassiri S, Hamelin R, Mozes A, et al. Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Rep. 2019;27:3062-3080.e11 pubmed publisher
Lightman S, Utley A, Lee K. Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle. Front Immunol. 2019;10:965 pubmed publisher
Hu Q, Sun W, Wang J, Ruan H, Zhang X, Ye Y, et al. Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. Nat Biomed Eng. 2018;2:831-840 pubmed publisher
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Jenkins R, Aref A, Lizotte P, Ivanova E, Stinson S, Zhou C, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018;8:196-215 pubmed publisher
Moreau J, Cen S, Berger A, Furlonger C, Paige C. Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo. PLoS ONE. 2017;12:e0185509 pubmed publisher
Clement M, Marsden M, Stacey M, Abdul Karim J, Gimeno Brias S, Costa Bento D, et al. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. PLoS Pathog. 2016;12:e1006050 pubmed publisher
Victorino F, Sojka D, Brodsky K, McNamee E, Masterson J, Homann D, et al. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015;195:4973-85 pubmed publisher
Drees J, Mertensotto M, Liu G, Panyam J, Leonard A, Augustin L, et al. Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model. Anticancer Res. 2015;35:843-9 pubmed
Byrne W, Murphy C, Cronin M, Wirth T, Tangney M. Bacterial-mediated DNA delivery to tumour associated phagocytic cells. J Control Release. 2014;196:384-93 pubmed publisher
Honjo K, Kubagawa Y, Jones D, DIZON B, Zhu Z, Ohno H, et al. Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (Fc?R). Proc Natl Acad Sci U S A. 2012;109:15882-7 pubmed
Younos I, Dafferner A, Gulen D, Britton H, Talmadge J. Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking. Int Immunopharmacol. 2012;13:245-56 pubmed publisher
Seyoum B, Yano M, Pirofski L. The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response. Vaccine. 2011;29:8002-11 pubmed publisher
Kim H, Lee M, Park A, Park E, Kim D, Ahn J, et al. Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice. Nephrology (Carlton). 2011;16:545-51 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
Qiu Q, Ravens I, Seth S, Rathinasamy A, Maier M, Davalos Misslitz A, et al. CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus. J Immunol. 2010;184:1681-9 pubmed publisher
Oertelt S, Lian Z, Cheng C, Chuang Y, Padgett K, He X, et al. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol. 2006;177:1655-60 pubmed
product information
Antigen :
CD49b
Apps. Abbrev. :
Flow Cytometry
Cat # :
108922
Clone :
DX5
Item :
PE/Cyanine7 anti-mouse CD49b (pan-NK cells)
Isotype :
Rat IgM, κ
Other Names :
α2 integrin, VLA-2 α chain, DX5, Integrin α2 chain, ITGA2
Size :
100 μg
Price (USD) :
248 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_CYANINE7
Immunogen :
IL-2-propagated NK1.1 + cells from C57BL/6 mice
Application Notes :
The DX5 clone detects cells expressing relatively high levels of CD49b and may not be useful for the detection of cells expressing low levels of CD49b. DX5 does not block NK cell killing or binding to collagen in vitro. Additional reported applications (for the relevant formats) include: complement-mediated cytotoxicity 2 and immunohistochemical staining 5 of formalin-fixed and paraffin-embedded tissue sections as well as immunohistochemical staining of acetone-fixed frozen sections 10 . The binding of DX5 antibody to splenic NK cells can be blocked by HMa2 antibody.
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA