PE/Cyanine7 anti-mouse CD49b (pan-NK cells) | BioLegend 108921 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Cyanine7 anti-mouse CD49b (pan-NK cells)

catalog :

108921

quantity :

25 μg

price :

95 USD

clonality :

monoclonal

host :

rat

conjugate :

PE/Cy7

clone name :

DX5

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 6	Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-Î² is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
flow cytometry; mouse	Drees J, Mertensotto M, Liu G, Panyam J, Leonard A, Augustin L, et al. Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model. Anticancer Res. 2015;35:843-9 pubmed
	Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019;29:787-803 pubmed publisher
	Liu D, Yin X, Olyha S, Nascimento M, Chen P, White T, et al. IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity. 2019;: pubmed publisher
	Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, et al. Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Sci Rep. 2019;9:6136 pubmed publisher
	He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
	Jenkins R, Aref A, Lizotte P, Ivanova E, Stinson S, Zhou C, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018;8:196-215 pubmed publisher
	Moreau J, Cen S, Berger A, Furlonger C, Paige C. Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo. PLoS ONE. 2017;12:e0185509 pubmed publisher
	Clement M, Marsden M, Stacey M, Abdul Karim J, Gimeno Brias S, Costa Bento D, et al. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. PLoS Pathog. 2016;12:e1006050 pubmed publisher
	Victorino F, Sojka D, Brodsky K, McNamee E, Masterson J, Homann D, et al. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015;195:4973-85 pubmed publisher
	Byrne W, Murphy C, Cronin M, Wirth T, Tangney M. Bacterial-mediated DNA delivery to tumour associated phagocytic cells. J Control Release. 2014;196:384-93 pubmed publisher
	Honjo K, Kubagawa Y, Jones D, DIZON B, Zhu Z, Ohno H, et al. Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (Fc?R). Proc Natl Acad Sci U S A. 2012;109:15882-7 pubmed
	Younos I, Dafferner A, Gulen D, Britton H, Talmadge J. Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking. Int Immunopharmacol. 2012;13:245-56 pubmed publisher
	Seyoum B, Yano M, Pirofski L. The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response. Vaccine. 2011;29:8002-11 pubmed publisher
	Kim H, Lee M, Park A, Park E, Kim D, Ahn J, et al. Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice. Nephrology (Carlton). 2011;16:545-51 pubmed publisher
	Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
	Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
	Qiu Q, Ravens I, Seth S, Rathinasamy A, Maier M, Davalos Misslitz A, et al. CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus. J Immunol. 2010;184:1681-9 pubmed publisher
	Oertelt S, Lian Z, Cheng C, Chuang Y, Padgett K, He X, et al. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol. 2006;177:1655-60 pubmed

product information

Antigen :

CD49b

Apps. Abbrev. :

Flow Cytometry

Cat # :

108921

Clone :

DX5

Item :

PE/Cyanine7 anti-mouse CD49b (pan-NK cells)

Isotype :

Rat IgM, κ

Other Names :

α2 integrin, VLA-2 α chain, DX5, Integrin α2 chain, ITGA2

Size :

25 μg

Price (USD) :

95 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PE_CYANINE7

Immunogen :

IL-2-propagated NK1.1 + cells from C57BL/6 mice

Application Notes :

The DX5 clone detects cells expressing relatively high levels of CD49b and may not be useful for the detection of cells expressing low levels of CD49b. DX5 does not block NK cell killing or binding to collagen in vitro. Additional reported applications (for the relevant formats) include: complement-mediated cytotoxicity 2 and immunohistochemical staining 5 of formalin-fixed and paraffin-embedded tissue sections as well as immunohistochemical staining of acetone-fixed frozen sections 10 . The binding of DX5 antibody to splenic NK cells can be blocked by HM 2 antibody.

more info or order :

BioLegend product webpage