product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-mouse CD49b (pan-NK cells)
catalog :
108909
quantity :
25 μg
price :
83 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
DX5
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 5e
Tzeng S, Patel K, Wilson D, Meyer R, Rhodes K, Green J. In situ genetic engineering of tumors for long-lasting and systemic immunotherapy. Proc Natl Acad Sci U S A. 2020;117:4043-4052 pubmed publisher
  • flow cytometry; mouse; fig 1
Pelly V, Kannan Y, Coomes S, Entwistle L, Rückerl D, Seddon B, et al. IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection. Mucosal Immunol. 2016;9:1407-1417 pubmed publisher
  • flow cytometry; mouse
Tassi I, Claudio E, Wang H, Tang W, Ha H, Saret S, et al. The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity. J Immunol. 2014;193:4303-11 pubmed publisher
Jee J, Yang L, Shivakumar P, Xu P, Mourya R, Thanekar U, et al. Maternal regulation of biliary disease in neonates via gut microbial metabolites. Nat Commun. 2022;13:18 pubmed publisher
Yang C, Wang Z, Li L, Zhang Z, Jin X, Wu P, et al. Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer. 2021;9: pubmed publisher
Shannon J, Cherry C, Vrba S, Hickman H. Protocol for analyzing and visualizing antiviral immune responses after acute infection of the murine oral mucosa. STAR Protoc. 2021;2:100790 pubmed publisher
Ludwik K, Sandusky Z, Wright E, Lannigan D. FACS protocol for direct comparison of cell populations isolated from mice. STAR Protoc. 2021;2:100270 pubmed publisher
Shannon J, Vrba S, Reynoso G, Wynne Jones E, Kamenyeva O, Malo C, et al. Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium. Immunity. 2021;54:276-290.e5 pubmed publisher
Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, et al. Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia. Cell. 2020;183:1867-1883.e26 pubmed publisher
Liu Z, Gu Y, Shin A, Zhang S, Ginhoux F. Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry. STAR Protoc. 2020;1:100029 pubmed publisher
Ludwik K, Sandusky Z, Stauffer K, Li Y, Boyd K, O Doherty G, et al. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. Cell Rep. 2020;32:107931 pubmed publisher
Mandour M, Soe P, Uyttenhove C, Van Snick J, Marbaix E, Coutelier J. Lactate dehydrogenase-elevating virus enhances natural killer cell-mediated immunosurveillance of mouse mesothelioma development. Infect Agent Cancer. 2020;15:30 pubmed publisher
Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, et al. MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Nat Commun. 2020;11:913 pubmed publisher
Rohner L, Reinhart R, Iype J, Bachmann S, Kaufmann T, Fux M. Impact of BH3-mimetics on Human and Mouse Blood Leukocytes: A Comparative Study. Sci Rep. 2020;10:222 pubmed publisher
Thi V, Jeon H, Park S, Lee H, Kim Y. Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice. Mol Cells. 2019;42:869-883 pubmed publisher
Liu Z, Gu Y, Chakarov S, Blériot C, Kwok I, Chen X, et al. Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell. 2019;178:1509-1525.e19 pubmed publisher
Niemann J, Woller N, Brooks J, Fleischmann Mundt B, Martin N, Kloos A, et al. Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy. Nat Commun. 2019;10:3236 pubmed publisher
Fujita K, Chakarov S, Kobayashi T, Sakamoto K, Voisin B, Duan K, et al. Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen. Proc Natl Acad Sci U S A. 2019;116:14714-14723 pubmed publisher
Hu J, Xu J, Li M, Zhang Y, Yi H, Chen J, et al. Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis. Mol Ther Nucleic Acids. 2019;16:650-662 pubmed publisher
LaFleur M, Nguyen T, Coxe M, Yates K, Trombley J, Weiss S, et al. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat Commun. 2019;10:1668 pubmed publisher
Denny J, Powers J, Castro H, Zhang J, Joshi Barve S, Campagna S, et al. Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis. Sci Rep. 2019;9:3472 pubmed publisher
Braza M, van Leent M, Lameijer M, Sanchez Gaytan B, Arts R, Pérez Medina C, et al. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity. 2018;49:819-828.e6 pubmed publisher
Shan M, Carrillo J, Yeste A, Gutzeit C, Segura Garzón D, Walland A, et al. Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44. Immunity. 2018;49:709-724.e8 pubmed publisher
Gentek R, Ghigo C, Hoeffel G, Bulle M, Msallam R, Gautier G, et al. Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells. Immunity. 2018;48:1160-1171.e5 pubmed publisher
Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, et al. Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells. Immunity. 2018;48:937-950.e8 pubmed publisher
Best S, De Souza D, Kersbergen A, Policheni A, Dayalan S, Tull D, et al. Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment. Cell Metab. 2018;27:935-943.e4 pubmed publisher
Ye Y, Wang C, Zhang X, Hu Q, Zhang Y, Liu Q, et al. A melanin-mediated cancer immunotherapy patch. Sci Immunol. 2017;2: pubmed publisher
Ho V, Hofs E, Elisia I, Lam V, Hsu B, Lai J, et al. All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages. PLoS ONE. 2016;11:e0168072 pubmed publisher
Belle J, Petrov J, Langlais D, Robert F, Cencic R, Shen S, et al. Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death Differ. 2016;23:759-75 pubmed publisher
Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, et al. Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding. PLoS ONE. 2015;10:e0134089 pubmed publisher
Honjo K, Kubagawa Y, Jones D, DIZON B, Zhu Z, Ohno H, et al. Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (Fc?R). Proc Natl Acad Sci U S A. 2012;109:15882-7 pubmed
Younos I, Dafferner A, Gulen D, Britton H, Talmadge J. Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking. Int Immunopharmacol. 2012;13:245-56 pubmed publisher
Pinto A, Paolicelli R, Salimova E, Gospocic J, Slonimsky E, Bilbao Cortes D, et al. An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile. PLoS ONE. 2012;7:e36814 pubmed publisher
Seyoum B, Yano M, Pirofski L. The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response. Vaccine. 2011;29:8002-11 pubmed publisher
Cohen M, Elkabets M, Perlmutter M, Porgador A, Voronov E, Apte R, et al. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol. 2010;185:5869-78 pubmed publisher
product information
Antigen :
CD49b
Apps. Abbrev. :
Flow Cytometry
Cat # :
108909
Clone :
DX5
Item :
APC anti-mouse CD49b (pan-NK cells)
Isotype :
Rat IgM, κ
Other Names :
α2 integrin, VLA-2 α chain, DX5, Integrin α2 chain, ITGA2
Size :
25 μg
Price (USD) :
83 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
APC
Immunogen :
IL-2-propagated NK1.1 + cells from C57BL/6 mice
Application Notes :
The DX5 clone detects cells expressing relatively high levels of CD49b and may not be useful for the detection of cells expressing low levels of CD49b. DX5 does not block NK cell killing or binding to collagen in vitro. Additional reported applications (for the relevant formats) include: complement-mediated cytotoxicity 2 and immunohistochemical staining 5 of formalin-fixed and paraffin-embedded tissue sections as well as immunohistochemical staining of acetone-fixed frozen sections 10 . The binding of DX5 antibody to splenic NK cells can be blocked by HMa2 antibody.
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA