Brilliant Violet 510™ anti-mouse Ly-6G/Ly-6C (Gr-1) | BioLegend 108457 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Brilliant Violet 510™ anti-mouse Ly-6G/Ly-6C (Gr-1)

catalog :

108457

quantity :

50 μg

price :

273 USD

clonality :

monoclonal

host :

rat

conjugate :

BV510

clone name :

RB6-8C5

reactivity :

human, mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...	Hemmi T, Ainai A, Hashiguchi T, Tobiume M, Kanno T, Iwata Yoshikawa N, et al. Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology. Vaccine. 2022;40:5892-5903 pubmed publisher
	Byrne P, Fisher B, Ambrozak D, Blade E, Tsybovsky Y, Graham B, et al. Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein. Nat Commun. 2023;14:1494 pubmed publisher
	Liu Y, Deguchi Y, Wei D, Liu F, Moussalli M, Deguchi E, et al. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun. 2022;13:2665 pubmed publisher
	Barsoumian H, Sezen D, Menon H, Younes A, Hu Y, He K, et al. High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses. Cancers (Basel). 2022;14: pubmed publisher
	Wang S, Ren D, Arkoun B, Kaushik A, Matherat G, Lecluse Y, et al. Lyl-1 regulates primitive macrophages and microglia development. Commun Biol. 2021;4:1382 pubmed publisher
	Werner A, Sch xe4 fer S, Zaytseva O, Albert H, Lux A, Kri x161 ti x107 J, et al. Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology. iScience. 2021;24:103076 pubmed publisher
	Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, B xfc ttner Herold M, Bach C, et al. β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Immunity. 2021;54:1772-1787.e9 pubmed publisher
	Danzer H, Glaesner J, Baerenwaldt A, Reitinger C, Lux A, Heger L, et al. Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis. elife. 2020;9: pubmed publisher
	Caetano M, Younes A, Barsoumian H, Quigley M, Menon H, Gao C, et al. Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses. Clin Cancer Res. 2019;25:7576-7584 pubmed publisher
	Olson W, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, et al. Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21. Cell Rep. 2019;28:2878-2891.e5 pubmed publisher
	Schmit N, Neopane K, Hantschel O. Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins. ACS Chem Biol. 2019;14:916-924 pubmed publisher
	Comazzetto S, Murphy M, Berto S, Jeffery E, Zhao Z, Morrison S. Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow. Cell Stem Cell. 2019;24:477-486.e6 pubmed publisher
	Postat J, Olekhnovitch R, Lemaitre F, Bousso P. A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses. Immunity. 2018;49:654-665.e5 pubmed publisher

product information

Antigen :

Ly-6G Ly-6C

Apps. Abbrev. :

Cat # :

108457

Clone :

RB6-8C5

Item :

Brilliant Violet 510™ anti-mouse Ly-6G/Ly-6C (Gr-1)

Isotype :

Rat IgG2b, κ

Other Names :

Gr-1

Size :

50 μg

Price (USD) :

273 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

BV510

Immunogen :

Raised against granulocytes of mouse origin

Application Notes :

Clone RB6-8C5 binds with high affinity to mouse Ly-6G molecules and to a lower extent to Ly-6C^19. Clone RB6-8C5 impairs the binding of anti-mouse Ly-6G clone 1A8^19. However, clone RB6-8C5 is able to stain in the presence of anti-mouse Ly-6C clone HK1.4^20.The RB6-8C5 antibody has been used to identify peripheral blood neutrophils and deplete granulocytes in vivo. Additional reported applications (for relevant formats of this clone) include: in vitro complement-mediated cytotoxicity^2, in vivo depletion^3-5,9, immunoprecipitation^1, immunohistochemical staining^6 (including paraffin-embedded sections^9,16,33-35, acetone-fixed frozen sections^11 and zinc-fixed sections^15), and Western blotting^7. RB6-8C5 is not suitable for depletion of hepatic myeloid derived suppressor cells (MDSCs)^20.Special Note: For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 108436).;

more info or order :

BioLegend product webpage